http://hdl.handle.net/10033/6839 Weitere Abteilungen und Arbeitsgruppen Thu, 20 Jun 2013 11:35:10 GMT 2013-06-20T11:35:10Z http://hdl.handle.net/10033/294263 Title: Bacterial invasion factors: Tools for crossing biological barriers and drug delivery? Authors: Kochut, Annika; Dersch, Petra Abstract: The oral route is the preferential route of drug delivery in humans. However, effective delivery through the gastrointestinal tract is often hampered by the low permeability of the intestinal epithelium. One possibility to overcome this problem is the encapsulation of drugs inside nanoparticulate systems, containing targeting moieties with cell invasive properties. The bioinvasive features of the delivery system could be provided by the attachment of bacterial invasion factors, which promote efficient uptake into host cells and mediate rapid transcytosis of the pathogen through the intestinal epithelium. This review gives an overview of bacterial invasion systems. The molecular structure and function of suitable bacterial invasins, their relative values as targeting agents and possible pitfalls of their use are described. The potential of bioinvasive drug delivery systems is mainly presented on the basis of the well-characterized Yersinia invasin protein, which enters M cells to gain access to subepithelial layers of the gastrointestinal tract, but alternative approaches and future prospects for oral drug delivery are also discussed. Sat, 01 Jun 2013 00:00:00 GMT http://hdl.handle.net/10033/294263 2013-06-01T00:00:00Z http://hdl.handle.net/10033/293089 Title: Total synthesis of antibiotics: recent achievements, limitations, and perspectives. Authors: Prusov, Evgeny V Abstract: Several recently accomplished total syntheses of antibiotic natural products were summarized in this review in order to present current trends in this area of research. Compounds from different substance classes, including polyketide, depsipeptide, polyketide-polypeptide hybrid, and saccharide, were chosen to demonstrate the advancement in both chemical methodology and corresponding synthetic strategy. Mon, 01 Apr 2013 00:00:00 GMT http://hdl.handle.net/10033/293089 2013-04-01T00:00:00Z http://hdl.handle.net/10033/288579 Title: Immunization with live virus vaccine protects highly susceptible DBA/2J mice from lethal influenza A H1N1 infection. Authors: Dengler, Leonie; May, Mathias; Wilk, Esther; Bahgat, Mahmoud M; Schughart, Klaus Abstract: The mouse represents an important model system to study the host response to influenza A infections and to evaluate new prevention or treatment strategies. We and others reported that the susceptibility to influenza A virus infections strongly varies among different inbred mouse strains. In particular, DBA/2J mice are highly susceptible to several influenza A subtypes, including human isolates and exhibit severe symptoms after infection with clinical isolates. Sun, 01 Jan 2012 00:00:00 GMT http://hdl.handle.net/10033/288579 2012-01-01T00:00:00Z http://hdl.handle.net/10033/283778 Title: Diversity of Bacillus-like organisms isolated from deep-sea hypersaline anoxic sediments. Authors: Sass, Andrea M; McKew, Boyd A; Sass, Henrik; Fichtel, Jörg; Timmis, Kenneth N; McGenity, Terry J Abstract: The deep-sea, hypersaline anoxic brine lakes in the Mediterranean are among the most extreme environments on earth, and in one of them, the MgCl2-rich Discovery basin, the presence of active microbes is equivocal. However, thriving microbial communities have been detected especially in the chemocline between deep seawater and three NaCl-rich brine lakes, l'Atalante, Bannock and Urania. By contrast, the microbiota of these brine-lake sediments remains largely unexplored. Tue, 01 Jan 2008 00:00:00 GMT http://hdl.handle.net/10033/283778 2008-01-01T00:00:00Z