Bioorthogonal metabolic glycoengineering of human larynx carcinoma (HEp-2) cells targeting sialic acid.

2.50
Hdl Handle:
http://hdl.handle.net/10033/118667
Title:
Bioorthogonal metabolic glycoengineering of human larynx carcinoma (HEp-2) cells targeting sialic acid.
Authors:
Homann, Arne; Qamar, Riaz-Ul; Serim, Sevnur; Dersch, Petra; Seibel, Jürgen
Abstract:
Sialic acids are located at the termini of mammalian cell-surface glycostructures, which participate in essential interaction processes including adhesion of pathogens prior to infection and immunogenicity. Here we present the synthesis and bioorthogonal metabolic incorporation of the sialic acid analogue N-(1-oxohex-5-ynyl)neuraminic acid (Neu5Hex) into the cell-surface glycocalyx of a human larynx carcinoma cell line (HEp-2) and its fluorescence labelling by click chemistry.
Affiliation:
University of Würzburg, Department of Organic Chemistry, Am Hubland, 97074 Würzburg, Germany.
Citation:
Bioorthogonal metabolic glycoengineering of human larynx carcinoma (HEp-2) cells targeting sialic acid. 2010, 6:24 Beilstein J Org Chem
Journal:
Beilstein journal of organic chemistry
Issue Date:
2010
URI:
http://hdl.handle.net/10033/118667
DOI:
10.3762/bjoc.6.24
PubMed ID:
20502611
Type:
Article
Language:
en
ISSN:
1860-5397
Appears in Collections:
publications of the department of molecular Infectionbiology (MIBI)

Full metadata record

DC FieldValue Language
dc.contributor.authorHomann, Arneen
dc.contributor.authorQamar, Riaz-Ulen
dc.contributor.authorSerim, Sevnuren
dc.contributor.authorDersch, Petraen
dc.contributor.authorSeibel, Jürgenen
dc.date.accessioned2011-01-05T14:01:40Z-
dc.date.available2011-01-05T14:01:40Z-
dc.date.issued2010-
dc.identifier.citationBioorthogonal metabolic glycoengineering of human larynx carcinoma (HEp-2) cells targeting sialic acid. 2010, 6:24 Beilstein J Org Chemen
dc.identifier.issn1860-5397-
dc.identifier.pmid20502611-
dc.identifier.doi10.3762/bjoc.6.24-
dc.identifier.urihttp://hdl.handle.net/10033/118667-
dc.description.abstractSialic acids are located at the termini of mammalian cell-surface glycostructures, which participate in essential interaction processes including adhesion of pathogens prior to infection and immunogenicity. Here we present the synthesis and bioorthogonal metabolic incorporation of the sialic acid analogue N-(1-oxohex-5-ynyl)neuraminic acid (Neu5Hex) into the cell-surface glycocalyx of a human larynx carcinoma cell line (HEp-2) and its fluorescence labelling by click chemistry.en
dc.language.isoenen
dc.titleBioorthogonal metabolic glycoengineering of human larynx carcinoma (HEp-2) cells targeting sialic acid.en
dc.typeArticleen
dc.contributor.departmentUniversity of Würzburg, Department of Organic Chemistry, Am Hubland, 97074 Würzburg, Germany.en
dc.identifier.journalBeilstein journal of organic chemistryen

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