The vinculin-DeltaIn20/21 mouse: characteristics of a constitutive, actin-binding deficient splice variant of vinculin.

2.50
Hdl Handle:
http://hdl.handle.net/10033/121048
Title:
The vinculin-DeltaIn20/21 mouse: characteristics of a constitutive, actin-binding deficient splice variant of vinculin.
Authors:
Marg, Susanna; Winkler, Ulrike; Sestu, Marcello; Himmel, Mirko; Schönherr, Madeleine; Bär, Janina; Mann, Amrit; Moser, Markus; Mierke, Claudia T; Rottner, Klemens; Blessing, Manfred; Hirrlinger, Johannes; Ziegler, Wolfgang H
Abstract:
The cytoskeletal adaptor protein vinculin plays a fundamental role in cell contact regulation and affects central aspects of cell motility, which are essential to both embryonal development and tissue homeostasis. Functional regulation of this evolutionarily conserved and ubiquitously expressed protein is dominated by a high-affinity, autoinhibitory head-to-tail interaction that spatially restricts ligand interactions to cell adhesion sites and, furthermore, limits the residency time of vinculin at these sites. To date, no mutants of the vinculin protein have been characterized in animal models.
Affiliation:
Faculty of Medicine, Interdisciplinary Centre for Clinical Research (IZKF) Leipzig, University of Leipzig, Leipzig, Germany.
Citation:
The vinculin-DeltaIn20/21 mouse: characteristics of a constitutive, actin-binding deficient splice variant of vinculin. 2010, 5 (7):e11530 PLoS ONE
Journal:
PloS one
Issue Date:
2010
URI:
http://hdl.handle.net/10033/121048
DOI:
10.1371/journal.pone.0011530
PubMed ID:
20644727
Type:
Article
Language:
en
ISSN:
1932-6203
Appears in Collections:
Publications of RG Cytoskeleton Dynamics (CYD)

Full metadata record

DC FieldValue Language
dc.contributor.authorMarg, Susannaen
dc.contributor.authorWinkler, Ulrikeen
dc.contributor.authorSestu, Marcelloen
dc.contributor.authorHimmel, Mirkoen
dc.contributor.authorSchönherr, Madeleineen
dc.contributor.authorBär, Janinaen
dc.contributor.authorMann, Amriten
dc.contributor.authorMoser, Markusen
dc.contributor.authorMierke, Claudia Ten
dc.contributor.authorRottner, Klemensen
dc.contributor.authorBlessing, Manfreden
dc.contributor.authorHirrlinger, Johannesen
dc.contributor.authorZiegler, Wolfgang Hen
dc.date.accessioned2011-02-03T10:37:55Z-
dc.date.available2011-02-03T10:37:55Z-
dc.date.issued2010-
dc.identifier.citationThe vinculin-DeltaIn20/21 mouse: characteristics of a constitutive, actin-binding deficient splice variant of vinculin. 2010, 5 (7):e11530 PLoS ONEen
dc.identifier.issn1932-6203-
dc.identifier.pmid20644727-
dc.identifier.doi10.1371/journal.pone.0011530-
dc.identifier.urihttp://hdl.handle.net/10033/121048-
dc.description.abstractThe cytoskeletal adaptor protein vinculin plays a fundamental role in cell contact regulation and affects central aspects of cell motility, which are essential to both embryonal development and tissue homeostasis. Functional regulation of this evolutionarily conserved and ubiquitously expressed protein is dominated by a high-affinity, autoinhibitory head-to-tail interaction that spatially restricts ligand interactions to cell adhesion sites and, furthermore, limits the residency time of vinculin at these sites. To date, no mutants of the vinculin protein have been characterized in animal models.en
dc.language.isoenen
dc.subject.meshActinsen
dc.subject.meshAnimalsen
dc.subject.meshCells, Cultureden
dc.subject.meshEmbryo, Mammalianen
dc.subject.meshFibroblastsen
dc.subject.meshImmunoblottingen
dc.subject.meshMiceen
dc.subject.meshProtein Bindingen
dc.subject.meshProtein Isoformsen
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen
dc.subject.meshVinculinen
dc.titleThe vinculin-DeltaIn20/21 mouse: characteristics of a constitutive, actin-binding deficient splice variant of vinculin.en
dc.typeArticleen
dc.contributor.departmentFaculty of Medicine, Interdisciplinary Centre for Clinical Research (IZKF) Leipzig, University of Leipzig, Leipzig, Germany.en
dc.identifier.journalPloS oneen

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