7-O-malonyl macrolactin A, a new macrolactin antibiotic from Bacillus subtilis active against methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and a small-colony variant of Burkholderia cepacia.

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Hdl Handle:
http://hdl.handle.net/10033/12307
Title:
7-O-malonyl macrolactin A, a new macrolactin antibiotic from Bacillus subtilis active against methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and a small-colony variant of Burkholderia cepacia.
Authors:
Romero-Tabarez, Magally; Jansen, Rolf; Sylla, Marita; Lünsdorf, Heinrich; Häussler, Susanne; Santosa, Dwi A; Timmis, Kenneth N; Molinari, Gabriella ( 0000-0002-6781-1292 )
Abstract:
We report here the discovery, isolation, and chemical and preliminary biological characterization of a new antibiotic compound, 7-O-malonyl macrolactin A (MMA), produced by a Bacillus subtilis soil isolate. MMA is a bacteriostatic antibiotic that inhibits a number of multidrug-resistant gram-positive bacterial pathogens, including methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and a small-colony variant of Burkholderia cepacia. MMA-treated staphylococci and enterococci were pseudomulticellular and exhibited multiple asymmetric initiation points of septum formation, indicating that MMA may inhibit a cell division function.
Citation:
Antimicrob. Agents Chemother. 2006, 50(5):1701-9
Issue Date:
1-May-2006
URI:
http://hdl.handle.net/10033/12307
DOI:
10.1128/AAC.50.5.1701-1709.2006
PubMed ID:
16641438
Type:
Article
Language:
en
ISSN:
0066-4804
Appears in Collections:
Publications of Division of Microbiology (MIK)

Full metadata record

DC FieldValue Language
dc.contributor.authorRomero-Tabarez, Magallyen
dc.contributor.authorJansen, Rolfen
dc.contributor.authorSylla, Maritaen
dc.contributor.authorLünsdorf, Heinrichen
dc.contributor.authorHäussler, Susanneen
dc.contributor.authorSantosa, Dwi Aen
dc.contributor.authorTimmis, Kenneth Nen
dc.contributor.authorMolinari, Gabriellaen
dc.date.accessioned2007-06-08T14:05:25Zen
dc.date.available2007-06-08T14:05:25Zen
dc.date.issued2006-05-01en
dc.identifier.citationAntimicrob. Agents Chemother. 2006, 50(5):1701-9en
dc.identifier.issn0066-4804en
dc.identifier.pmid16641438en
dc.identifier.doi10.1128/AAC.50.5.1701-1709.2006en
dc.identifier.urihttp://hdl.handle.net/10033/12307en
dc.description.abstractWe report here the discovery, isolation, and chemical and preliminary biological characterization of a new antibiotic compound, 7-O-malonyl macrolactin A (MMA), produced by a Bacillus subtilis soil isolate. MMA is a bacteriostatic antibiotic that inhibits a number of multidrug-resistant gram-positive bacterial pathogens, including methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and a small-colony variant of Burkholderia cepacia. MMA-treated staphylococci and enterococci were pseudomulticellular and exhibited multiple asymmetric initiation points of septum formation, indicating that MMA may inhibit a cell division function.en
dc.format.extent5522432 bytesen
dc.format.extent7211488 bytesen
dc.format.mimetypeapplication/msworden
dc.format.mimetypeapplication/pdfen
dc.language.isoenen
dc.title7-O-malonyl macrolactin A, a new macrolactin antibiotic from Bacillus subtilis active against methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and a small-colony variant of Burkholderia cepacia.en
dc.typeArticleen
dc.format.digYESen
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