7-O-malonyl macrolactin A, a new macrolactin antibiotic from Bacillus subtilis active against methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and a small-colony variant of Burkholderia cepacia.

2.50
Hdl Handle:
http://hdl.handle.net/10033/12307
Title:
7-O-malonyl macrolactin A, a new macrolactin antibiotic from Bacillus subtilis active against methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and a small-colony variant of Burkholderia cepacia.
Authors:
Romero-Tabarez, Magally; Jansen, Rolf; Sylla, Marita; Lünsdorf, Heinrich; Häussler, Susanne; Santosa, Dwi A; Timmis, Kenneth N; Molinari, Gabriella
Abstract:
We report here the discovery, isolation, and chemical and preliminary biological characterization of a new antibiotic compound, 7-O-malonyl macrolactin A (MMA), produced by a Bacillus subtilis soil isolate. MMA is a bacteriostatic antibiotic that inhibits a number of multidrug-resistant gram-positive bacterial pathogens, including methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and a small-colony variant of Burkholderia cepacia. MMA-treated staphylococci and enterococci were pseudomulticellular and exhibited multiple asymmetric initiation points of septum formation, indicating that MMA may inhibit a cell division function.
Citation:
Antimicrob. Agents Chemother. 2006, 50(5):1701-9
Issue Date:
1-May-2006
URI:
http://hdl.handle.net/10033/12307
DOI:
10.1128/AAC.50.5.1701-1709.2006
PubMed ID:
16641438
Type:
Article
Language:
en
ISSN:
0066-4804
Appears in Collections:
Publications of Division of Microbiology (MIK)

Full metadata record

DC FieldValue Language
dc.contributor.authorRomero-Tabarez, Magally-
dc.contributor.authorJansen, Rolf-
dc.contributor.authorSylla, Marita-
dc.contributor.authorLünsdorf, Heinrich-
dc.contributor.authorHäussler, Susanne-
dc.contributor.authorSantosa, Dwi A-
dc.contributor.authorTimmis, Kenneth N-
dc.contributor.authorMolinari, Gabriella-
dc.date.accessioned2007-06-08T14:05:25Z-
dc.date.available2007-06-08T14:05:25Z-
dc.date.issued2006-05-01-
dc.identifier.citationAntimicrob. Agents Chemother. 2006, 50(5):1701-9en
dc.identifier.issn0066-4804-
dc.identifier.pmid16641438-
dc.identifier.doi10.1128/AAC.50.5.1701-1709.2006-
dc.identifier.urihttp://hdl.handle.net/10033/12307-
dc.description.abstractWe report here the discovery, isolation, and chemical and preliminary biological characterization of a new antibiotic compound, 7-O-malonyl macrolactin A (MMA), produced by a Bacillus subtilis soil isolate. MMA is a bacteriostatic antibiotic that inhibits a number of multidrug-resistant gram-positive bacterial pathogens, including methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and a small-colony variant of Burkholderia cepacia. MMA-treated staphylococci and enterococci were pseudomulticellular and exhibited multiple asymmetric initiation points of septum formation, indicating that MMA may inhibit a cell division function.en
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dc.format.extent7211488 bytes-
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dc.format.mimetypeapplication/pdf-
dc.language.isoenen
dc.title7-O-malonyl macrolactin A, a new macrolactin antibiotic from Bacillus subtilis active against methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and a small-colony variant of Burkholderia cepacia.en
dc.typeArticleen
dc.format.digYES-
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