2.50
Hdl Handle:
http://hdl.handle.net/10033/123333
Title:
Immune modulators with defined molecular targets: cornerstone to optimize rational vaccine design.
Authors:
Ebensen, Thomas ( 0000-0001-8906-063X ) ; Guzmán, Carlos A
Abstract:
Vaccination remains the most valuable tool for preventing infectious diseases. However, the performance of many existing vaccines should be improved and there are diseases for which vaccines are still not available. The use of well-defined antigens for the generation of subunit vaccines has led to products with an improved safety profile. However, purified antigens are usually poorly immunogenic, making essential the use of adjuvants. Despite the fact that adjuvants have been used to increase the immunogenicity of vaccines for more than 70 years, only a handful has been licensed for human use (e.g., aluminium salts, the micro-fluidized squalene-in-water emulsion MF59 and monophosphoryl lipid A). Thus, the development of new adjuvants which are able to promote broad and sustained immune responses at systemic and mucosal levels still remains as a major challenge in vaccinology. Recent advances in our understanding of the immune system have facilitated the identification of new biological targets for screening programs aimed at the discovery of novel immune stimulators. This resulted in the identification of new candidate adjuvants, which made possible the modulation of the immune responses elicited according to specific needs. A number of promising adjuvants which are currently under preclinical or clinical development will be described in this review.
Affiliation:
Department of Vaccinology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Citation:
Immune modulators with defined molecular targets: cornerstone to optimize rational vaccine design., 4 (1):13-22 Hum Vaccin
Journal:
Human vaccines
Issue Date:
2-Mar-2011
URI:
http://hdl.handle.net/10033/123333
PubMed ID:
18376145
Type:
Article
Language:
en
ISSN:
1554-8619
Appears in Collections:
publications of the research group vaccinology and applied microbiology (VAC)

Full metadata record

DC FieldValue Language
dc.contributor.authorEbensen, Thomasen
dc.contributor.authorGuzmán, Carlos Aen
dc.date.accessioned2011-03-02T12:55:22Zen
dc.date.available2011-03-02T12:55:22Zen
dc.date.issued2011-03-02T12:55:22Zen
dc.identifier.citationImmune modulators with defined molecular targets: cornerstone to optimize rational vaccine design., 4 (1):13-22 Hum Vaccinen
dc.identifier.issn1554-8619en
dc.identifier.pmid18376145en
dc.identifier.urihttp://hdl.handle.net/10033/123333en
dc.description.abstractVaccination remains the most valuable tool for preventing infectious diseases. However, the performance of many existing vaccines should be improved and there are diseases for which vaccines are still not available. The use of well-defined antigens for the generation of subunit vaccines has led to products with an improved safety profile. However, purified antigens are usually poorly immunogenic, making essential the use of adjuvants. Despite the fact that adjuvants have been used to increase the immunogenicity of vaccines for more than 70 years, only a handful has been licensed for human use (e.g., aluminium salts, the micro-fluidized squalene-in-water emulsion MF59 and monophosphoryl lipid A). Thus, the development of new adjuvants which are able to promote broad and sustained immune responses at systemic and mucosal levels still remains as a major challenge in vaccinology. Recent advances in our understanding of the immune system have facilitated the identification of new biological targets for screening programs aimed at the discovery of novel immune stimulators. This resulted in the identification of new candidate adjuvants, which made possible the modulation of the immune responses elicited according to specific needs. A number of promising adjuvants which are currently under preclinical or clinical development will be described in this review.en
dc.language.isoenen
dc.subject.meshAdjuvants, Immunologicen
dc.subject.meshAnimalsen
dc.subject.meshHumansen
dc.subject.meshImmunity, Mucosalen
dc.subject.meshVaccinesen
dc.titleImmune modulators with defined molecular targets: cornerstone to optimize rational vaccine design.en
dc.typeArticleen
dc.contributor.departmentDepartment of Vaccinology, Helmholtz Centre for Infection Research, Braunschweig, Germany.en
dc.identifier.journalHuman vaccinesen
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