2.50
HDL Handle:
http://hdl.handle.net/10033/12401
Title:
The biophysics of T lymphocyte activation in vitro and in vivo.
Authors:
Reichardt, Peter; Gunzer, Matthias
Abstract:
T cell activation is crucial for the development of specific immune reactions. It requires physical contact between T cells and antigen-presenting cells (APC). Since these cells are initially located at distinct positions in the body, they have to migrate and find each other within secondary lymphoid organs. After encountering each other both cells have to maintain a close membrane contact sufficiently long to ensure successful signaling. Thus, there is the necessity to temporarily synchronize the motile behavior of these cells. Initially, it had been proposed that during antigen recognition, T cells receive a stop signal and maintain a stable contact with APC for several hours when an appropriate APC has been encountered. However, direct cell observation via time-lapse microscopy in vitro and in vivo has revealed a different picture. While long contacts can be observed, many interactions appear to be very short and sequential despite efficient signaling. Thus, two concepts addressing the biophysics of T cell activation have emerged. The single encounter model proposes that after a period of dynamic searching, a T cell stops to interact with one appropriately presenting APC until signaling is completed. The serial encounter model suggests that T cells are able to collect a series of short signals by different APC until a critical activation threshold is achieved. Future research needs to clarify the relative importance of short and dynamic versus long-lived T cell-APC encounters for the outcome of T cell activation. Furthermore, a thorough understanding of the molecular events underlying the observed complex motility patterns will make these phenomena amenable for intervention, which might result in the identification of new types of immune modulating drugs.
Citation:
Results Probl Cell Differ 2006, 43:199-218
Issue Date:
2006
URI:
http://hdl.handle.net/10033/12401
PubMed ID:
17068973
Type:
Article
Language:
en
ISSN:
0080-1844
Appears in Collections:
Publications of JRG Immunodynamics (ID)

Full metadata record

DC FieldValueLanguage
dc.contributor.authorReichardt, Peter-
dc.contributor.authorGunzer, Matthias-
dc.date.accessioned2007-06-20T10:45:50Z-
dc.date.available2007-06-20T10:45:50Z-
dc.date.issued2006-
dc.identifier.citationResults Probl Cell Differ 2006, 43:199-218en
dc.identifier.issn0080-1844-
dc.identifier.pmid17068973-
dc.identifier.urihttp://hdl.handle.net/10033/12401-
dc.description.abstractT cell activation is crucial for the development of specific immune reactions. It requires physical contact between T cells and antigen-presenting cells (APC). Since these cells are initially located at distinct positions in the body, they have to migrate and find each other within secondary lymphoid organs. After encountering each other both cells have to maintain a close membrane contact sufficiently long to ensure successful signaling. Thus, there is the necessity to temporarily synchronize the motile behavior of these cells. Initially, it had been proposed that during antigen recognition, T cells receive a stop signal and maintain a stable contact with APC for several hours when an appropriate APC has been encountered. However, direct cell observation via time-lapse microscopy in vitro and in vivo has revealed a different picture. While long contacts can be observed, many interactions appear to be very short and sequential despite efficient signaling. Thus, two concepts addressing the biophysics of T cell activation have emerged. The single encounter model proposes that after a period of dynamic searching, a T cell stops to interact with one appropriately presenting APC until signaling is completed. The serial encounter model suggests that T cells are able to collect a series of short signals by different APC until a critical activation threshold is achieved. Future research needs to clarify the relative importance of short and dynamic versus long-lived T cell-APC encounters for the outcome of T cell activation. Furthermore, a thorough understanding of the molecular events underlying the observed complex motility patterns will make these phenomena amenable for intervention, which might result in the identification of new types of immune modulating drugs.en
dc.format.extent3322969 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoenen
dc.titleThe biophysics of T lymphocyte activation in vitro and in vivo.en
dc.typeArticleen
dc.format.digYES-

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