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The intriguing cyclophilin A-HIV-1 Vpr interaction: prolyl cis/trans isomerisation catalysis and specific binding.
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| Title: | The intriguing cyclophilin A-HIV-1 Vpr interaction: prolyl cis/trans isomerisation catalysis and specific binding. |
| Authors: | Solbak, Sara M
Reksten, Tove R
Wray, Victor
Bruns, Karsten
Horvli, Ole
Raae, Arnt J
Henklein, Petra
Henklein, Peter
Röder, Rene
Mitzner, David
Schubert, Ulrich
Fossen, Torgils |
| Affiliation: | Department of Chemistry, University of Bergen, N-5007 Bergen, Norway. |
| Citation: | The intriguing cyclophilin A-HIV-1 Vpr interaction: prolyl cis/trans isomerisation catalysis and specific binding. 2010, 10:31 BMC Struct. Biol. |
| Journal: | BMC structural biology |
| Issue Date: | 2010 |
| URI: | http://hdl.handle.net/10033/124027 |
| DOI: | 10.1186/1472-6807-10-31 |
| PubMed ID: | 20920334 |
| Abstract: | Cyclophilin A (CypA) represents a potential target for antiretroviral therapy since inhibition of CypA suppresses human immunodeficiency virus type 1 (HIV-1) replication, although the mechanism through which CypA modulates HIV-1 infectivity still remains unclear. The interaction of HIV-1 viral protein R (Vpr) with the human peptidyl prolyl isomerase CypA is known to occur in vitro and in vivo. However, the nature of the interaction of CypA with Pro-35 of N-terminal Vpr has remained undefined. |
| Type: | Article |
| Language: | en |
| MeSH: | Cyclophilin A
Humans
Kinetics
Nuclear Magnetic Resonance, Biomolecular
Peptidylprolyl Isomerase
Proline
Protein Binding
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Surface Plasmon Resonance
Virus Replication
vpr Gene Products, Human Immunodeficiency Virus |
| ISSN: | 1472-6807 |
| Appears in Collections: | Publications from RG Biophysical Analysis (BA)
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| Related articles on PubMed | |  | Cyclophilin A interacts with HIV-1 Vpr and is required for its functional expression.Zander K, Sherman MP, Tessmer U, Bruns K, Wray V, Prechtel AT, Schubert E, Henklein P, Luban J, Neidleman J, Greene WC, Schubert U 2003 Oct 31 |
| | | | | See all 102 articles |
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