2.50
Hdl Handle:
http://hdl.handle.net/10033/128113
Title:
To be or not to be a Treg cell: lineage decisions controlled by epigenetic mechanisms.
Authors:
Toker, Aras; Huehn, Jochen
Abstract:
Regulatory T (T(reg)) cells are a unique CD4(+) T cell lineage that plays a crucial role in the maintenance of immunological tolerance. The Forkhead box transcription factor Foxp3 is critically involved in T(reg) cell development and responsible for determining the suppressive function of these cells. The majority of Foxp3(+) T(reg) cells are generated during T cell development within the thymus and show features of a stable T cell lineage. New work indicates that both induction and stabilization of Foxp3 expression are under epigenetic control, which suggests that selective interference with the underlying chromatin remodeling mechanisms might enable the development of future therapeutic strategies targeting T(reg) cells.
Affiliation:
Experimental Immunology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany.
Citation:
To be or not to be a Treg cell: lineage decisions controlled by epigenetic mechanisms. 2011, 4 (158):pe4 Sci Signal
Journal:
Science signaling
Issue Date:
2011
URI:
http://hdl.handle.net/10033/128113
DOI:
10.1126/scisignal.2001783
PubMed ID:
21285410
Type:
Article
Language:
en
ISSN:
1937-9145
Appears in Collections:
publications of the division experimentelle Immunologie (EXIM)

Full metadata record

DC FieldValue Language
dc.contributor.authorToker, Arasen
dc.contributor.authorHuehn, Jochenen
dc.date.accessioned2011-04-14T09:34:46Z-
dc.date.available2011-04-14T09:34:46Z-
dc.date.issued2011-
dc.identifier.citationTo be or not to be a Treg cell: lineage decisions controlled by epigenetic mechanisms. 2011, 4 (158):pe4 Sci Signalen
dc.identifier.issn1937-9145-
dc.identifier.pmid21285410-
dc.identifier.doi10.1126/scisignal.2001783-
dc.identifier.urihttp://hdl.handle.net/10033/128113-
dc.description.abstractRegulatory T (T(reg)) cells are a unique CD4(+) T cell lineage that plays a crucial role in the maintenance of immunological tolerance. The Forkhead box transcription factor Foxp3 is critically involved in T(reg) cell development and responsible for determining the suppressive function of these cells. The majority of Foxp3(+) T(reg) cells are generated during T cell development within the thymus and show features of a stable T cell lineage. New work indicates that both induction and stabilization of Foxp3 expression are under epigenetic control, which suggests that selective interference with the underlying chromatin remodeling mechanisms might enable the development of future therapeutic strategies targeting T(reg) cells.en
dc.language.isoenen
dc.titleTo be or not to be a Treg cell: lineage decisions controlled by epigenetic mechanisms.en
dc.typeArticleen
dc.contributor.departmentExperimental Immunology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany.en
dc.identifier.journalScience signalingen

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