2.50
HDL Handle:
http://hdl.handle.net/10033/134750
Title:
Biological activity of volatiles from marine and terrestrial bacteria.
Authors:
Schulz, Stefan; Dickschat, Jeroen S; Kunze, Brigitte; Wagner-Döbler, Irene; Diestel, Randi; Sasse, Florenz
Abstract:
The antiproliferative activity of 52 volatile compounds released from bacteria was investigated in agar diffusion assays against medically important microorganisms and mouse fibroblasts. Furthermore, the activity of these compounds to interfere with the quorum-sensing-systems was tested with two different reporter strains. While some of the compounds specific to certain bacteria showed some activity in the antiproliferative assay, the compounds common to many bacteria were mostly inactive. In contrast, some of these compounds were active in the quorum-sensing-tests. γ-Lactones showed a broad reactivity, while pyrazines seem to have only low intrinsic activity. A general discussion on the ecological importance of these findings is given.
Affiliation:
Institute of Organic Chemistry, University of Braunschweig-Institute of Technology, Hagenring 30, Braunschweig, Germany. Stefan.Schulz@tu-bs.de
Citation:
Biological activity of volatiles from marine and terrestrial bacteria. 2010, 8 (12):2976-87 Mar Drugs
Journal:
Marine drugs
Issue Date:
2010
URI:
http://hdl.handle.net/10033/134750
DOI:
10.3390/md8122976
PubMed ID:
21339960
Type:
Article
Language:
en
ISSN:
1660-3397
Appears in Collections:
Publications of RG Microbial Communication (KOM)

Full metadata record

DC FieldValueLanguage
dc.contributor.authorSchulz, Stefanen
dc.contributor.authorDickschat, Jeroen Sen
dc.contributor.authorKunze, Brigitteen
dc.contributor.authorWagner-Döbler, Ireneen
dc.contributor.authorDiestel, Randien
dc.contributor.authorSasse, Florenzen
dc.date.accessioned2011-06-28T10:56:50Z-
dc.date.available2011-06-28T10:56:50Z-
dc.date.issued2010-
dc.identifier.citationBiological activity of volatiles from marine and terrestrial bacteria. 2010, 8 (12):2976-87 Mar Drugsen
dc.identifier.issn1660-3397-
dc.identifier.pmid21339960-
dc.identifier.doi10.3390/md8122976-
dc.identifier.urihttp://hdl.handle.net/10033/134750-
dc.description.abstractThe antiproliferative activity of 52 volatile compounds released from bacteria was investigated in agar diffusion assays against medically important microorganisms and mouse fibroblasts. Furthermore, the activity of these compounds to interfere with the quorum-sensing-systems was tested with two different reporter strains. While some of the compounds specific to certain bacteria showed some activity in the antiproliferative assay, the compounds common to many bacteria were mostly inactive. In contrast, some of these compounds were active in the quorum-sensing-tests. γ-Lactones showed a broad reactivity, while pyrazines seem to have only low intrinsic activity. A general discussion on the ecological importance of these findings is given.en
dc.language.isoenen
dc.titleBiological activity of volatiles from marine and terrestrial bacteria.en
dc.typeArticleen
dc.contributor.departmentInstitute of Organic Chemistry, University of Braunschweig-Institute of Technology, Hagenring 30, Braunschweig, Germany. Stefan.Schulz@tu-bs.deen
dc.identifier.journalMarine drugsen
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