2.50
Hdl Handle:
http://hdl.handle.net/10033/140594
Title:
Peritoneal Cavity Is Dominated by IFNγ-Secreting CXCR3 Th1 Cells.
Authors:
Zygmunt, Beata M; Groebe, Lothar; Guzman, Carlos A
Abstract:
The chemokine receptor CXCR3, which was shown to take part in many inflammatory processes, is considered as a Th1 specific marker. Here, we show in a mouse model that CXCR3 expressing CD4(+) cells preferentially migrate to the peritoneal cavity under steady-state conditions. The peritoneal cavity milieu leads to an up-regulated expression of CXCR3. However, blocking of known ligands of this chemokine receptor did not alter the preferential migration. The peritoneal cavity environment also results in an increased percentage of memory cells producing cytokines. Up-regulation of IFNγ production occurs mostly in CXCR3(+) cells considered as Th1, whereas the up-regulation of IL-4 affects mostly in CXCR3(-) cells which are considered as Th2. We conclude that the peritoneal cavity does not change the Th-lineage of the cells, but that domination of this anatomic niche by Th1 cells rather results from preferential migration to this compartment.
Affiliation:
Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Citation:
Peritoneal Cavity Is Dominated by IFNγ-Secreting CXCR3 Th1 Cells. 2011, 6 (7):e18032 PLoS ONE
Journal:
PloS one
Issue Date:
2011
URI:
http://hdl.handle.net/10033/140594
DOI:
10.1371/journal.pone.0018032
PubMed ID:
21789162
Type:
Article
Language:
en
ISSN:
1932-6203
Appears in Collections:
publications of the research group vaccinology and applied microbiology (VAC)

Full metadata record

DC FieldValue Language
dc.contributor.authorZygmunt, Beata Men
dc.contributor.authorGroebe, Lotharen
dc.contributor.authorGuzman, Carlos Aen
dc.date.accessioned2011-08-24T12:11:03Z-
dc.date.available2011-08-24T12:11:03Z-
dc.date.issued2011-
dc.identifier.citationPeritoneal Cavity Is Dominated by IFNγ-Secreting CXCR3 Th1 Cells. 2011, 6 (7):e18032 PLoS ONEen
dc.identifier.issn1932-6203-
dc.identifier.pmid21789162-
dc.identifier.doi10.1371/journal.pone.0018032-
dc.identifier.urihttp://hdl.handle.net/10033/140594-
dc.description.abstractThe chemokine receptor CXCR3, which was shown to take part in many inflammatory processes, is considered as a Th1 specific marker. Here, we show in a mouse model that CXCR3 expressing CD4(+) cells preferentially migrate to the peritoneal cavity under steady-state conditions. The peritoneal cavity milieu leads to an up-regulated expression of CXCR3. However, blocking of known ligands of this chemokine receptor did not alter the preferential migration. The peritoneal cavity environment also results in an increased percentage of memory cells producing cytokines. Up-regulation of IFNγ production occurs mostly in CXCR3(+) cells considered as Th1, whereas the up-regulation of IL-4 affects mostly in CXCR3(-) cells which are considered as Th2. We conclude that the peritoneal cavity does not change the Th-lineage of the cells, but that domination of this anatomic niche by Th1 cells rather results from preferential migration to this compartment.en
dc.language.isoenen
dc.titlePeritoneal Cavity Is Dominated by IFNγ-Secreting CXCR3 Th1 Cells.en
dc.typeArticleen
dc.contributor.departmentDepartment of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany.en
dc.identifier.journalPloS oneen

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