Immune responses induced in cattle by vaccination with a recombinant adenovirus expressing Mycobacterial antigen 85A and Mycobacterium bovis BCG.

2.50
Hdl Handle:
http://hdl.handle.net/10033/14555
Title:
Immune responses induced in cattle by vaccination with a recombinant adenovirus expressing Mycobacterial antigen 85A and Mycobacterium bovis BCG.
Authors:
Vordermeier, H Martin; Huygen, Kris; Singh, Mahavir; Hewinson, R Glyn; Xing, Zhou
Abstract:
Cattle were vaccinated with an adenovirus expressing the mycobacterial antigen 85A (rAd85A), with Mycobacterium bovis BCG followed by rAd85A heterologous boosting, or with rAd85A followed by BCG boosting. BCG/rAd85A resulted in the highest direct gamma interferon responses. Cultured enzyme-linked immunospot assay analysis demonstrated that memory responses were induced by all three protocols but were strongest after BCG/rAd85A and rAd85A/BCG vaccination.
Citation:
Infect. Immun. 2006, 74(2):1416-8
Issue Date:
1-Feb-2006
URI:
http://hdl.handle.net/10033/14555
DOI:
10.1128/IAI.74.2.1416-1418.2006
PubMed ID:
16428796
Type:
Article
Language:
en
ISSN:
0019-9567
Appears in Collections:
publications of the research group genomeanalytics (GMAK)

Full metadata record

DC FieldValue Language
dc.contributor.authorVordermeier, H Martin-
dc.contributor.authorHuygen, Kris-
dc.contributor.authorSingh, Mahavir-
dc.contributor.authorHewinson, R Glyn-
dc.contributor.authorXing, Zhou-
dc.date.accessioned2007-11-13T14:31:29Z-
dc.date.available2007-11-13T14:31:29Z-
dc.date.issued2006-02-01-
dc.identifier.citationInfect. Immun. 2006, 74(2):1416-8en
dc.identifier.issn0019-9567-
dc.identifier.pmid16428796-
dc.identifier.doi10.1128/IAI.74.2.1416-1418.2006-
dc.identifier.urihttp://hdl.handle.net/10033/14555-
dc.description.abstractCattle were vaccinated with an adenovirus expressing the mycobacterial antigen 85A (rAd85A), with Mycobacterium bovis BCG followed by rAd85A heterologous boosting, or with rAd85A followed by BCG boosting. BCG/rAd85A resulted in the highest direct gamma interferon responses. Cultured enzyme-linked immunospot assay analysis demonstrated that memory responses were induced by all three protocols but were strongest after BCG/rAd85A and rAd85A/BCG vaccination.en
dc.format.extent146635 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoenen
dc.titleImmune responses induced in cattle by vaccination with a recombinant adenovirus expressing Mycobacterial antigen 85A and Mycobacterium bovis BCG.en
dc.typeArticleen
dc.format.digYES-

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