2.50
Hdl Handle:
http://hdl.handle.net/10033/19553
Title:
Genetic variation in group A streptococci.
Authors:
McMillan, David J; Sriprakash, Kadaba S; Chhatwal, Gursharan S
Abstract:
Group A streptococcus (GAS) is responsible for a range of human diseases that vary in their clinical manifestations and severity. While numerous virulence factors have been described, the way these factors interact to promote different streptococcal diseases is less clear. In order to identify multifactorial relationships between GAS and the human host, novel high-throughput techniques such as microarrays are necessary. We have performed comparative studies using custom-designed virulence arrays to enhance our understanding of the high degree of genotypic variation that occurs in streptococci. This study has pointed to mobile genetic elements as the major agents that promote variation. Our results show that multiple combinations of genes might bring about similar clinical pictures. This adds further complexity to the intricate relationship between pathogen and host.
Affiliation:
Department of Microbial Pathogenesis, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, D-38124 Braunschweig, Germany.
Citation:
Genetic variation in group A streptococci. 2007, 297 (7-8):525-32 Int. J. Med. Microbiol.
Journal:
International journal of medical microbiology : IJMM
Issue Date:
Nov-2007
URI:
http://hdl.handle.net/10033/19553
DOI:
10.1016/j.ijmm.2007.02.007
PubMed ID:
17459766
Type:
Article
Language:
en
ISSN:
1438-4221
Appears in Collections:
Publications of Dept. Medizinische Mikrobiologie (MMIK)

Full metadata record

DC FieldValue Language
dc.contributor.authorMcMillan, David J-
dc.contributor.authorSriprakash, Kadaba S-
dc.contributor.authorChhatwal, Gursharan S-
dc.date.accessioned2008-03-03T14:20:49Z-
dc.date.available2008-03-03T14:20:49Z-
dc.date.issued2007-11-
dc.identifier.citationGenetic variation in group A streptococci. 2007, 297 (7-8):525-32 Int. J. Med. Microbiol.en
dc.identifier.issn1438-4221-
dc.identifier.pmid17459766-
dc.identifier.doi10.1016/j.ijmm.2007.02.007-
dc.identifier.urihttp://hdl.handle.net/10033/19553-
dc.description.abstractGroup A streptococcus (GAS) is responsible for a range of human diseases that vary in their clinical manifestations and severity. While numerous virulence factors have been described, the way these factors interact to promote different streptococcal diseases is less clear. In order to identify multifactorial relationships between GAS and the human host, novel high-throughput techniques such as microarrays are necessary. We have performed comparative studies using custom-designed virulence arrays to enhance our understanding of the high degree of genotypic variation that occurs in streptococci. This study has pointed to mobile genetic elements as the major agents that promote variation. Our results show that multiple combinations of genes might bring about similar clinical pictures. This adds further complexity to the intricate relationship between pathogen and host.en
dc.language.isoenen
dc.subject.meshGenotypeen
dc.subject.meshHumansen
dc.subject.meshStreptococcal Infectionsen
dc.subject.meshStreptococcusen
dc.subject.meshStreptococcus pyogenesen
dc.subject.meshVariation (Genetics)en
dc.titleGenetic variation in group A streptococci.en
dc.typeArticleen
dc.contributor.departmentDepartment of Microbial Pathogenesis, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, D-38124 Braunschweig, Germany.en
dc.identifier.journalInternational journal of medical microbiology : IJMMen

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