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Induction of a mature hepatocyte phenotype in adult liver derived progenitor cells by ectopic expression of transcription factors.
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| Title: | Induction of a mature hepatocyte phenotype in adult liver derived progenitor cells by ectopic expression of transcription factors. |
| Authors: | Iacob, Razvan Rüdrich, Urda Rothe, Michael Kirsch, Sarah Maasoumy, Benjamin Narain, Nidhi Verfaillie, Catherine M Sancho-Bru, Pau Iken, Marcus Popescu, Irinel Schambach, Axel Manns, Michael P Bock, Michael |
| Affiliation: | Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany. |
| Citation: | Induction of a mature hepatocyte phenotype in adult liver derived progenitor cells by ectopic expression of transcription factors. 2011, 6 (3):251-61 Stem Cell Res |
| Journal: | Stem cell research |
| Issue Date: | May-2011 |
| URI: | http://hdl.handle.net/10033/196495 |
| DOI: | 10.1016/j.scr.2011.02.002 |
| PubMed ID: | 21474405 |
| Abstract: | By ectopic expression of a distinct combination of transcription factors we aimed to induce a mature hepatocyte phenotype in an adult liver derived progenitor cell population (ALDPC). |
| Type: | Article |
| Language: | en |
| MeSH: | Adult Stem Cells Animals Cell Differentiation Cells, Cultured Gene Expression Hepatocytes Liver Mice Mice, Inbred C57BL Transcription Factors |
| ISSN: | 1876-7753 |
| Appears in Collections: | publications of AG Cell and Gene therapy
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| Jacob et al_final.pdf | original manuscript | 347Kb | Adobe PDF |  View/Open | | Figure 1.tif | figure 1 | 137Kb | TIFF |  View/Open | | Figure 2.tif | figure 2 | 20Kb | TIFF |  View/Open | | Figure 3.tif | figure 3 | 30Kb | TIFF |  View/Open | | Figure 4.tif | figure 4 | 101Kb | TIFF |  View/Open | | Figure 5.tif | figure 5 | 65Kb | TIFF |  View/Open | | Figure 6.tif | figure 6 | 760Kb | TIFF |  View/Open | | Figure 7.tif | figure 7 | 689Kb | TIFF |  View/Open | | Supplementary Material.pdf | supplementary materials | 1622Kb | Adobe PDF |  View/Open |
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| Related articles on PubMed | | | | |  | Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells.Roelandt P, Pauwelyn KA, Sancho-Bru P, Subramanian K, Bose B, Ordovas L, Vanuytsel K, Geraerts M, Firpo M, De Vos R, Fevery J, Nevens F, Hu WS, Verfaillie CM 2010 Aug 11 |
| | See all 90 articles |
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