2.50
Hdl Handle:
http://hdl.handle.net/10033/200889
Title:
Theoretical model for cellular shapes driven by protrusive and adhesive forces.
Authors:
Kabaso, Doron; Shlomovitz, Roie; Schloen, Kathrin; Stradal, Theresia; Gov, Nir S
Abstract:
The forces that arise from the actin cytoskeleton play a crucial role in determining the cell shape. These include protrusive forces due to actin polymerization and adhesion to the external matrix. We present here a theoretical model for the cellular shapes resulting from the feedback between the membrane shape and the forces acting on the membrane, mediated by curvature-sensitive membrane complexes of a convex shape. In previous theoretical studies we have investigated the regimes of linear instability where spontaneous formation of cellular protrusions is initiated. Here we calculate the evolution of a two dimensional cell contour beyond the linear regime and determine the final steady-state shapes arising within the model. We find that shapes driven by adhesion or by actin polymerization (lamellipodia) have very different morphologies, as observed in cells. Furthermore, we find that as the strength of the protrusive forces diminish, the system approaches a stabilization of a periodic pattern of protrusions. This result can provide an explanation for a number of puzzling experimental observations regarding cellular shape dependence on the properties of the extra-cellular matrix.
Affiliation:
Department of Chemical Physics, The Weizmann Institute of Science, Rehovot, Israel.
Citation:
Theoretical model for cellular shapes driven by protrusive and adhesive forces. 2011, 7 (5):e1001127 PLoS Comput. Biol.
Journal:
PLoS computational biology
Issue Date:
May-2011
URI:
http://hdl.handle.net/10033/200889
DOI:
10.1371/journal.pcbi.1001127
PubMed ID:
21573201
Type:
Article
Language:
en
ISSN:
1553-7358
Appears in Collections:
Publications of RG Signalling and Motility (SIM)

Full metadata record

DC FieldValue Language
dc.contributor.authorKabaso, Doronen
dc.contributor.authorShlomovitz, Roieen
dc.contributor.authorSchloen, Kathrinen
dc.contributor.authorStradal, Theresiaen
dc.contributor.authorGov, Nir Sen
dc.date.accessioned2012-01-09T10:43:20Z-
dc.date.available2012-01-09T10:43:20Z-
dc.date.issued2011-05-
dc.identifier.citationTheoretical model for cellular shapes driven by protrusive and adhesive forces. 2011, 7 (5):e1001127 PLoS Comput. Biol.en
dc.identifier.issn1553-7358-
dc.identifier.pmid21573201-
dc.identifier.doi10.1371/journal.pcbi.1001127-
dc.identifier.urihttp://hdl.handle.net/10033/200889-
dc.description.abstractThe forces that arise from the actin cytoskeleton play a crucial role in determining the cell shape. These include protrusive forces due to actin polymerization and adhesion to the external matrix. We present here a theoretical model for the cellular shapes resulting from the feedback between the membrane shape and the forces acting on the membrane, mediated by curvature-sensitive membrane complexes of a convex shape. In previous theoretical studies we have investigated the regimes of linear instability where spontaneous formation of cellular protrusions is initiated. Here we calculate the evolution of a two dimensional cell contour beyond the linear regime and determine the final steady-state shapes arising within the model. We find that shapes driven by adhesion or by actin polymerization (lamellipodia) have very different morphologies, as observed in cells. Furthermore, we find that as the strength of the protrusive forces diminish, the system approaches a stabilization of a periodic pattern of protrusions. This result can provide an explanation for a number of puzzling experimental observations regarding cellular shape dependence on the properties of the extra-cellular matrix.en
dc.language.isoenen
dc.subject.meshActinsen
dc.subject.meshAnimalsen
dc.subject.meshBiomechanicsen
dc.subject.meshCell Adhesionen
dc.subject.meshCell Shapeen
dc.subject.meshCells, Cultureden
dc.subject.meshCytoskeletonen
dc.subject.meshExtracellular Matrixen
dc.subject.meshFibroblastsen
dc.subject.meshMiceen
dc.subject.meshModels, Biologicalen
dc.subject.meshPseudopodiaen
dc.titleTheoretical model for cellular shapes driven by protrusive and adhesive forces.en
dc.typeArticleen
dc.contributor.departmentDepartment of Chemical Physics, The Weizmann Institute of Science, Rehovot, Israel.en
dc.identifier.journalPLoS computational biologyen

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