CD4+CD25+ regulatory T cells control CD8+ T-cell effector differentiation by modulating IL-2 homeostasis.

2.50
HDL Handle:
http://hdl.handle.net/10033/201253
Title:
CD4+CD25+ regulatory T cells control CD8+ T-cell effector differentiation by modulating IL-2 homeostasis.
Authors:
McNally, Alice; Hill, Geoffrey R; Sparwasser, Tim; Thomas, Ranjeny; Steptoe, Raymond J
Abstract:
CD4(+)CD25(+) regulatory T cells (Treg) play a crucial role in the regulation of immune responses. Although many mechanisms of Treg suppression in vitro have been described, the mechanisms by which Treg modulate CD8(+) T cell differentiation and effector function in vivo are more poorly defined. It has been proposed, in many instances, that modulation of cytokine homeostasis could be an important mechanism by which Treg regulate adaptive immunity; however, direct experimental evidence is sparse. Here we demonstrate that CD4(+)CD25(+) Treg, by critically regulating IL-2 homeostasis, modulate CD8(+) T-cell effector differentiation. Expansion and effector differentiation of CD8(+) T cells is promoted by autocrine IL-2 but, by competing for IL-2, Treg limit CD8(+) effector differentiation. Furthermore, a regulatory loop exists between Treg and CD8(+) effector T cells, where IL-2 produced during CD8(+) T-cell effector differentiation promotes Treg expansion.
Affiliation:
University of Queensland Diamantina Institute, University of Queensland, Brisbane 4072, Australia.
Citation:
CD4+CD25+ regulatory T cells control CD8+ T-cell effector differentiation by modulating IL-2 homeostasis. 2011, 108 (18):7529-34 Proc. Natl. Acad. Sci. U.S.A.
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Issue Date:
3-May-2011
URI:
http://hdl.handle.net/10033/201253
DOI:
10.1073/pnas.1103782108
PubMed ID:
21502514
Type:
Article
Language:
en
ISSN:
1091-6490
Appears in Collections:
publications of the TwinCore unit experimental infectionresearch

Full metadata record

DC FieldValueLanguage
dc.contributor.authorMcNally, Aliceen
dc.contributor.authorHill, Geoffrey Ren
dc.contributor.authorSparwasser, Timen
dc.contributor.authorThomas, Ranjenyen
dc.contributor.authorSteptoe, Raymond Jen
dc.date.accessioned2012-01-10T13:39:01Z-
dc.date.available2012-01-10T13:39:01Z-
dc.date.issued2011-05-03-
dc.identifier.citationCD4+CD25+ regulatory T cells control CD8+ T-cell effector differentiation by modulating IL-2 homeostasis. 2011, 108 (18):7529-34 Proc. Natl. Acad. Sci. U.S.A.en
dc.identifier.issn1091-6490-
dc.identifier.pmid21502514-
dc.identifier.doi10.1073/pnas.1103782108-
dc.identifier.urihttp://hdl.handle.net/10033/201253-
dc.description.abstractCD4(+)CD25(+) regulatory T cells (Treg) play a crucial role in the regulation of immune responses. Although many mechanisms of Treg suppression in vitro have been described, the mechanisms by which Treg modulate CD8(+) T cell differentiation and effector function in vivo are more poorly defined. It has been proposed, in many instances, that modulation of cytokine homeostasis could be an important mechanism by which Treg regulate adaptive immunity; however, direct experimental evidence is sparse. Here we demonstrate that CD4(+)CD25(+) Treg, by critically regulating IL-2 homeostasis, modulate CD8(+) T-cell effector differentiation. Expansion and effector differentiation of CD8(+) T cells is promoted by autocrine IL-2 but, by competing for IL-2, Treg limit CD8(+) effector differentiation. Furthermore, a regulatory loop exists between Treg and CD8(+) effector T cells, where IL-2 produced during CD8(+) T-cell effector differentiation promotes Treg expansion.en
dc.language.isoenen
dc.subject.meshAdaptive Immunityen
dc.subject.meshAnalysis of Varianceen
dc.subject.meshAnimalsen
dc.subject.meshAntibodies, Monoclonalen
dc.subject.meshCD8-Positive T-Lymphocytesen
dc.subject.meshCell Differentiationen
dc.subject.meshEnzyme-Linked Immunosorbent Assayen
dc.subject.meshFlow Cytometryen
dc.subject.meshHomeostasisen
dc.subject.meshInterleukin-2en
dc.subject.meshMiceen
dc.subject.meshMice, Inbred C57BLen
dc.subject.meshMice, Transgenicen
dc.subject.meshT-Lymphocytes, Regulatoryen
dc.titleCD4+CD25+ regulatory T cells control CD8+ T-cell effector differentiation by modulating IL-2 homeostasis.en
dc.typeArticleen
dc.contributor.departmentUniversity of Queensland Diamantina Institute, University of Queensland, Brisbane 4072, Australia.en
dc.identifier.journalProceedings of the National Academy of Sciences of the United States of Americaen

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