Expression of S100A8/A9 in HaCaT keratinocytes alters the rate of cell proliferation and differentiation.

2.50
Hdl Handle:
http://hdl.handle.net/10033/202630
Title:
Expression of S100A8/A9 in HaCaT keratinocytes alters the rate of cell proliferation and differentiation.
Authors:
Voss, Andreas; Bode, Günther; Sopalla, Claudia; Benedyk, Malgorzata; Varga, Georg; Böhm, Markus; Nacken, Wolfgang; Kerkhoff, Claus
Abstract:
S100A8/A9 promotes NADPH oxidase in HaCaT keratinocytes and subsequently increases NFκB activation, which plays important roles in the balance between epidermal growth and differentiation. S100A8/A9-positive HaCaT cells present with a significantly reduced rate of cell division and greater expression of two keratinocyte differentiation markers, involucrin and filaggrin, than control cells. S100A8/A9 mutants fail to enhance NFκB activation, TNFα-induced IL-8 gene expression and NFκB p65 phosphorylation, and S100A8/A9-positive cells demonstrate better cell survival in forced suspension culture than mutant cells. S100A8/A9 is induced in epithelial cells in response to stress. Therefore, S100A8/A9-mediated growth arrest could have implications for tissue remodeling and repair.
Affiliation:
Institute of Immunology, University of Muenster, Muenster, Germany.
Citation:
Expression of S100A8/A9 in HaCaT keratinocytes alters the rate of cell proliferation and differentiation. 2011, 585 (2):440-6 FEBS Lett.
Journal:
FEBS letters
Issue Date:
21-Jan-2011
URI:
http://hdl.handle.net/10033/202630
DOI:
10.1016/j.febslet.2010.12.037
PubMed ID:
21192933
Type:
Article
Language:
en
ISSN:
1873-3468
Appears in Collections:
publications of the RG Immunalterung und chronische Infektion (IMCI)

Full metadata record

DC FieldValue Language
dc.contributor.authorVoss, Andreasen
dc.contributor.authorBode, Güntheren
dc.contributor.authorSopalla, Claudiaen
dc.contributor.authorBenedyk, Malgorzataen
dc.contributor.authorVarga, Georgen
dc.contributor.authorBöhm, Markusen
dc.contributor.authorNacken, Wolfgangen
dc.contributor.authorKerkhoff, Clausen
dc.date.accessioned2012-01-12T13:10:55Z-
dc.date.available2012-01-12T13:10:55Z-
dc.date.issued2011-01-21-
dc.identifier.citationExpression of S100A8/A9 in HaCaT keratinocytes alters the rate of cell proliferation and differentiation. 2011, 585 (2):440-6 FEBS Lett.en
dc.identifier.issn1873-3468-
dc.identifier.pmid21192933-
dc.identifier.doi10.1016/j.febslet.2010.12.037-
dc.identifier.urihttp://hdl.handle.net/10033/202630-
dc.description.abstractS100A8/A9 promotes NADPH oxidase in HaCaT keratinocytes and subsequently increases NFκB activation, which plays important roles in the balance between epidermal growth and differentiation. S100A8/A9-positive HaCaT cells present with a significantly reduced rate of cell division and greater expression of two keratinocyte differentiation markers, involucrin and filaggrin, than control cells. S100A8/A9 mutants fail to enhance NFκB activation, TNFα-induced IL-8 gene expression and NFκB p65 phosphorylation, and S100A8/A9-positive cells demonstrate better cell survival in forced suspension culture than mutant cells. S100A8/A9 is induced in epithelial cells in response to stress. Therefore, S100A8/A9-mediated growth arrest could have implications for tissue remodeling and repair.en
dc.language.isoenen
dc.subject.meshAdaptation, Physiologicalen
dc.subject.meshCalgranulin Aen
dc.subject.meshCalgranulin Ben
dc.subject.meshCell Differentiationen
dc.subject.meshCell Lineen
dc.subject.meshCell Proliferationen
dc.subject.meshEpithelial Cellsen
dc.subject.meshHumansen
dc.subject.meshKeratinocytesen
dc.subject.meshNF-kappa Ben
dc.titleExpression of S100A8/A9 in HaCaT keratinocytes alters the rate of cell proliferation and differentiation.en
dc.typeArticleen
dc.contributor.departmentInstitute of Immunology, University of Muenster, Muenster, Germany.en
dc.identifier.journalFEBS lettersen

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