The promoter of human telomerase reverse transcriptase is activated during liver regeneration and hepatocyte proliferation.

2.50
Hdl Handle:
http://hdl.handle.net/10033/210669
Title:
The promoter of human telomerase reverse transcriptase is activated during liver regeneration and hepatocyte proliferation.
Authors:
Sirma, Hüseyin; Kumar, Mukesh; Meena, Jitendra K; Witt, Britta; Weise, Julia M; Lechel, Andre; Ande, Satyanarayana; Sakk, Vadim; Guguen-Guillouzo, Christiane; Zender, Lars; Rudolph, Karl-Lenhard; Günes, Cagatay
Abstract:
Telomerase activity has not been detected in healthy human liver biopsy samples, but it is up-regulated in most human liver tumors. It is not clear whether telomerase is activated in response to acute or chronic liver injury. Telomerase activity is closely associated with expression of its catalytic subunit, telomerase reverse transcriptase (TERT). We analyzed the activity of the human TERT (hTERT) promoter during liver regeneration in vivo and hepatocyte proliferation in vitro.
Affiliation:
Heinrich-Pette-Institute, Hamburg, Germany.
Citation:
The promoter of human telomerase reverse transcriptase is activated during liver regeneration and hepatocyte proliferation. 2011, 141 (1):326-37, 337.e1-3 Gastroenterology
Journal:
Gastroenterology
Issue Date:
Jul-2011
URI:
http://hdl.handle.net/10033/210669
DOI:
10.1053/j.gastro.2011.03.047
PubMed ID:
21447332
Type:
Article
Language:
en
ISSN:
1528-0012
Appears in Collections:
Publications of NG Chronische Infektionen und Krebs CHIK

Full metadata record

DC FieldValue Language
dc.contributor.authorSirma, Hüseyinen
dc.contributor.authorKumar, Mukeshen
dc.contributor.authorMeena, Jitendra Ken
dc.contributor.authorWitt, Brittaen
dc.contributor.authorWeise, Julia Men
dc.contributor.authorLechel, Andreen
dc.contributor.authorAnde, Satyanarayanaen
dc.contributor.authorSakk, Vadimen
dc.contributor.authorGuguen-Guillouzo, Christianeen
dc.contributor.authorZender, Larsen
dc.contributor.authorRudolph, Karl-Lenharden
dc.contributor.authorGünes, Cagatayen
dc.date.accessioned2012-02-14T10:14:50Z-
dc.date.available2012-02-14T10:14:50Z-
dc.date.issued2011-07-
dc.identifier.citationThe promoter of human telomerase reverse transcriptase is activated during liver regeneration and hepatocyte proliferation. 2011, 141 (1):326-37, 337.e1-3 Gastroenterologyen
dc.identifier.issn1528-0012-
dc.identifier.pmid21447332-
dc.identifier.doi10.1053/j.gastro.2011.03.047-
dc.identifier.urihttp://hdl.handle.net/10033/210669-
dc.description.abstractTelomerase activity has not been detected in healthy human liver biopsy samples, but it is up-regulated in most human liver tumors. It is not clear whether telomerase is activated in response to acute or chronic liver injury. Telomerase activity is closely associated with expression of its catalytic subunit, telomerase reverse transcriptase (TERT). We analyzed the activity of the human TERT (hTERT) promoter during liver regeneration in vivo and hepatocyte proliferation in vitro.en
dc.language.isoenen
dc.subject.meshAnimalsen
dc.subject.meshBinding Sitesen
dc.subject.meshCell Differentiationen
dc.subject.meshCell Proliferationen
dc.subject.meshCells, Cultureden
dc.subject.meshChromatin Immunoprecipitationen
dc.subject.meshE2F2 Transcription Factoren
dc.subject.meshE2F7 Transcription Factoren
dc.subject.meshGene Expression Regulation, Enzymologicen
dc.subject.meshGenes, Reporteren
dc.subject.meshHepatectomyen
dc.subject.meshHepatocytesen
dc.subject.meshHumansen
dc.subject.meshLac Operonen
dc.subject.meshLiveren
dc.subject.meshLiver Regenerationen
dc.subject.meshMaleen
dc.subject.meshMiceen
dc.subject.meshMice, Inbred C57BLen
dc.subject.meshMice, Transgenicen
dc.subject.meshPromoter Regions, Geneticen
dc.subject.meshRNA Interferenceen
dc.subject.meshRegulatory Elements, Transcriptionalen
dc.subject.meshRetinoblastoma Proteinen
dc.subject.meshTelomeraseen
dc.subject.meshTime Factorsen
dc.subject.meshTranscriptional Activationen
dc.titleThe promoter of human telomerase reverse transcriptase is activated during liver regeneration and hepatocyte proliferation.en
dc.typeArticleen
dc.contributor.departmentHeinrich-Pette-Institute, Hamburg, Germany.en
dc.identifier.journalGastroenterologyen

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