A replicating cytomegalovirus-based vaccine encoding a single Ebola virus nucleoprotein CTL epitope confers protection against Ebola virus.

2.50
HDL Handle:
http://hdl.handle.net/10033/213809
Title:
A replicating cytomegalovirus-based vaccine encoding a single Ebola virus nucleoprotein CTL epitope confers protection against Ebola virus.
Authors:
Tsuda, Yoshimi; Caposio, Patrizia; Parkins, Christopher J; Botto, Sara; Messaoudi, Ilhem; Cicin-Sain, Luka; Feldmann, Heinz; Jarvis, Michael A
Abstract:
Human outbreaks of Ebola virus (EBOV) are a serious human health concern in Central Africa. Great apes (gorillas/chimpanzees) are an important source of EBOV transmission to humans due to increased hunting of wildlife including the 'bush-meat' trade. Cytomegalovirus (CMV) is an highly immunogenic virus that has shown recent utility as a vaccine platform. CMV-based vaccines also have the unique potential to re-infect and disseminate through target populations regardless of prior CMV immunity, which may be ideal for achieving high vaccine coverage in inaccessible populations such as great apes.
Affiliation:
Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America.
Citation:
A replicating cytomegalovirus-based vaccine encoding a single Ebola virus nucleoprotein CTL epitope confers protection against Ebola virus. 2011, 5 (8):e1275 PLoS Negl Trop Dis
Journal:
PLoS neglected tropical diseases
Issue Date:
Aug-2011
URI:
http://hdl.handle.net/10033/213809
DOI:
10.1371/journal.pntd.0001275
PubMed ID:
21858240
Type:
Article
Language:
en
ISSN:
1935-2735
Appears in Collections:
publications of the RG Immunalterung und chronische Infektion (IMCI)

Full metadata record

DC FieldValueLanguage
dc.contributor.authorTsuda, Yoshimien
dc.contributor.authorCaposio, Patriziaen
dc.contributor.authorParkins, Christopher Jen
dc.contributor.authorBotto, Saraen
dc.contributor.authorMessaoudi, Ilhemen
dc.contributor.authorCicin-Sain, Lukaen
dc.contributor.authorFeldmann, Heinzen
dc.contributor.authorJarvis, Michael Aen
dc.date.accessioned2012-03-01T15:40:56Z-
dc.date.available2012-03-01T15:40:56Z-
dc.date.issued2011-08-
dc.identifier.citationA replicating cytomegalovirus-based vaccine encoding a single Ebola virus nucleoprotein CTL epitope confers protection against Ebola virus. 2011, 5 (8):e1275 PLoS Negl Trop Disen
dc.identifier.issn1935-2735-
dc.identifier.pmid21858240-
dc.identifier.doi10.1371/journal.pntd.0001275-
dc.identifier.urihttp://hdl.handle.net/10033/213809-
dc.description.abstractHuman outbreaks of Ebola virus (EBOV) are a serious human health concern in Central Africa. Great apes (gorillas/chimpanzees) are an important source of EBOV transmission to humans due to increased hunting of wildlife including the 'bush-meat' trade. Cytomegalovirus (CMV) is an highly immunogenic virus that has shown recent utility as a vaccine platform. CMV-based vaccines also have the unique potential to re-infect and disseminate through target populations regardless of prior CMV immunity, which may be ideal for achieving high vaccine coverage in inaccessible populations such as great apes.en
dc.language.isoenen
dc.subject.meshAnimalsen
dc.subject.meshCD8-Positive T-Lymphocytesen
dc.subject.meshDrug Carriersen
dc.subject.meshEbola Vaccinesen
dc.subject.meshEbolavirusen
dc.subject.meshEpitopes, T-Lymphocyteen
dc.subject.meshFemaleen
dc.subject.meshGenetic Vectorsen
dc.subject.meshHemorrhagic Fever, Ebolaen
dc.subject.meshMiceen
dc.subject.meshMice, Inbred C57BLen
dc.subject.meshMuromegalovirusen
dc.subject.meshNucleoproteinsen
dc.subject.meshT-Lymphocytes, Cytotoxicen
dc.subject.meshVaccines, Subuniten
dc.subject.meshVaccines, Syntheticen
dc.titleA replicating cytomegalovirus-based vaccine encoding a single Ebola virus nucleoprotein CTL epitope confers protection against Ebola virus.en
dc.typeArticleen
dc.contributor.departmentLaboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America.en
dc.identifier.journalPLoS neglected tropical diseasesen

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