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A replicating cytomegalovirus-based vaccine encoding a single Ebola virus nucleoprotein CTL epitope confers protection against Ebola virus.
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| Title: | A replicating cytomegalovirus-based vaccine encoding a single Ebola virus nucleoprotein CTL epitope confers protection against Ebola virus. |
| Authors: | Tsuda, Yoshimi
Caposio, Patrizia
Parkins, Christopher J
Botto, Sara
Messaoudi, Ilhem
Cicin-Sain, Luka
Feldmann, Heinz
Jarvis, Michael A |
| Affiliation: | Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America. |
| Citation: | A replicating cytomegalovirus-based vaccine encoding a single Ebola virus nucleoprotein CTL epitope confers protection against Ebola virus. 2011, 5 (8):e1275 PLoS Negl Trop Dis |
| Journal: | PLoS neglected tropical diseases |
| Issue Date: | Aug-2011 |
| URI: | http://hdl.handle.net/10033/213809 |
| DOI: | 10.1371/journal.pntd.0001275 |
| PubMed ID: | 21858240 |
| Abstract: | Human outbreaks of Ebola virus (EBOV) are a serious human health concern in Central Africa. Great apes (gorillas/chimpanzees) are an important source of EBOV transmission to humans due to increased hunting of wildlife including the 'bush-meat' trade. Cytomegalovirus (CMV) is an highly immunogenic virus that has shown recent utility as a vaccine platform. CMV-based vaccines also have the unique potential to re-infect and disseminate through target populations regardless of prior CMV immunity, which may be ideal for achieving high vaccine coverage in inaccessible populations such as great apes. |
| Type: | Article |
| Language: | en |
| MeSH: | Animals
CD8-Positive T-Lymphocytes
Drug Carriers
Ebola Vaccines
Ebolavirus
Epitopes, T-Lymphocyte
Female
Genetic Vectors
Hemorrhagic Fever, Ebola
Mice
Mice, Inbred C57BL
Muromegalovirus
Nucleoproteins
T-Lymphocytes, Cytotoxic
Vaccines, Subunit
Vaccines, Synthetic |
| ISSN: | 1935-2735 |
| Appears in Collections: | publications of the RG Immunalterung und chronische Infektion (IMCI)
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