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A replicating cytomegalovirus-based vaccine encoding a single Ebola virus nucleoprotein CTL epitope confers protection against Ebola virus.
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|Title: ||A replicating cytomegalovirus-based vaccine encoding a single Ebola virus nucleoprotein CTL epitope confers protection against Ebola virus.|
|Affiliation: ||Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America.|
|Citation: ||A replicating cytomegalovirus-based vaccine encoding a single Ebola virus nucleoprotein CTL epitope confers protection against Ebola virus. 2011, 5 (8):e1275 PLoS Negl Trop Dis|
|Journal: ||PLoS neglected tropical diseases|
|Issue Date: ||Aug-2011 |
|PubMed ID: ||21858240|
|Abstract: ||Human outbreaks of Ebola virus (EBOV) are a serious human health concern in Central Africa. Great apes (gorillas/chimpanzees) are an important source of EBOV transmission to humans due to increased hunting of wildlife including the 'bush-meat' trade. Cytomegalovirus (CMV) is an highly immunogenic virus that has shown recent utility as a vaccine platform. CMV-based vaccines also have the unique potential to re-infect and disseminate through target populations regardless of prior CMV immunity, which may be ideal for achieving high vaccine coverage in inaccessible populations such as great apes.|
Hemorrhagic Fever, Ebola
Mice, Inbred C57BL
|Appears in Collections: ||publications of the RG Immunalterung und chronische Infektion (IMCI)|
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