Outbreak due to a Klebsiella pneumoniae strain harbouring KPC-2 and VIM-1 in a German university hospital, July 2010 to January 2011.

2.50
Hdl Handle:
http://hdl.handle.net/10033/213989
Title:
Outbreak due to a Klebsiella pneumoniae strain harbouring KPC-2 and VIM-1 in a German university hospital, July 2010 to January 2011.
Authors:
Steinmann, J; Kaase, M; Gatermann, S; Popp, W; Steinmann, E; Damman, M; Paul, A; Saner, F; Buer, J; Rath, Pm
Abstract:
We describe the epidemiology and characteristics of the pathogen and patients (n=7) associated with an outbreak of a carbapenem-resistant Klebsiella pneumoniae (CRKP) strain in a German university hospital from July 2010 to January 2011. Species identification and detection of carbapenem resistance were carried out using standard microbiological procedures. Carbapenemases were detected by phenotypic methods and specific polymerase chain reactions (PCRs). DNA fingerprinting profiles were performed with repetitive sequence-based PCR. Medical records of colonised or infected patients were retrospectively reviewed. Antibiotic resistance profiles, PCR-specific amplification products and genotyping demonstrated that the outbreak occurred because of the spread of a single CRKP clone harbouring both KPC-2 and VIM-1. Five of the seven patients had invasive infections with the CRKP strain; the deaths of four of them were directly related to the infection. Early implementation of infection control interventions brought about efficient containment of further cross-transmission. Rapid dissemination of carbapenemase-producing Enterobacteriaceae is a serious concern in patient care and is a problem that has emerged in western Europe.
Affiliation:
Institute of Medical Microbiology, University Hospital Essen, University of Duisburg- Essen, Essen, Germany. joerg.steinmann@uk-essen.de
Citation:
Outbreak due to a Klebsiella pneumoniae strain harbouring KPC-2 and VIM-1 in a German university hospital, July 2010 to January 2011. 2011, 16 (33): Euro Surveill.
Journal:
Euro surveillance : bulletin européen sur les maladies transmissibles = European communicable disease bulletin
Issue Date:
2011
URI:
http://hdl.handle.net/10033/213989
PubMed ID:
21871227
Type:
Article
Language:
en
ISSN:
1560-7917
Appears in Collections:
Publications of the Twincore unit Experimental Virology(EVIR)

Full metadata record

DC FieldValue Language
dc.contributor.authorSteinmann, Jen
dc.contributor.authorKaase, Men
dc.contributor.authorGatermann, Sen
dc.contributor.authorPopp, Wen
dc.contributor.authorSteinmann, Een
dc.contributor.authorDamman, Men
dc.contributor.authorPaul, Aen
dc.contributor.authorSaner, Fen
dc.contributor.authorBuer, Jen
dc.contributor.authorRath, Pmen
dc.date.accessioned2012-03-02T10:50:33Z-
dc.date.available2012-03-02T10:50:33Z-
dc.date.issued2011-
dc.identifier.citationOutbreak due to a Klebsiella pneumoniae strain harbouring KPC-2 and VIM-1 in a German university hospital, July 2010 to January 2011. 2011, 16 (33): Euro Surveill.en
dc.identifier.issn1560-7917-
dc.identifier.pmid21871227-
dc.identifier.urihttp://hdl.handle.net/10033/213989-
dc.description.abstractWe describe the epidemiology and characteristics of the pathogen and patients (n=7) associated with an outbreak of a carbapenem-resistant Klebsiella pneumoniae (CRKP) strain in a German university hospital from July 2010 to January 2011. Species identification and detection of carbapenem resistance were carried out using standard microbiological procedures. Carbapenemases were detected by phenotypic methods and specific polymerase chain reactions (PCRs). DNA fingerprinting profiles were performed with repetitive sequence-based PCR. Medical records of colonised or infected patients were retrospectively reviewed. Antibiotic resistance profiles, PCR-specific amplification products and genotyping demonstrated that the outbreak occurred because of the spread of a single CRKP clone harbouring both KPC-2 and VIM-1. Five of the seven patients had invasive infections with the CRKP strain; the deaths of four of them were directly related to the infection. Early implementation of infection control interventions brought about efficient containment of further cross-transmission. Rapid dissemination of carbapenemase-producing Enterobacteriaceae is a serious concern in patient care and is a problem that has emerged in western Europe.en
dc.language.isoenen
dc.subject.meshAdulten
dc.subject.meshAgeden
dc.subject.meshAnti-Bacterial Agentsen
dc.subject.meshCarbenicillinen
dc.subject.meshCross Infectionen
dc.subject.meshDNA Fingerprintingen
dc.subject.meshDisease Outbreaksen
dc.subject.meshDrug Resistance, Multiple, Bacterialen
dc.subject.meshFemaleen
dc.subject.meshGenotypeen
dc.subject.meshGermanyen
dc.subject.meshHospitals, Universityen
dc.subject.meshHumansen
dc.subject.meshIntensive Care Unitsen
dc.subject.meshKlebsiella Infectionsen
dc.subject.meshKlebsiella pneumoniaeen
dc.subject.meshMaleen
dc.subject.meshMicrobial Sensitivity Testsen
dc.subject.meshMiddle Ageden
dc.subject.meshPolymerase Chain Reactionen
dc.subject.meshRetrospective Studiesen
dc.subject.meshSequence Analysis, DNAen
dc.subject.meshYoung Adulten
dc.subject.meshbeta-Lactamasesen
dc.titleOutbreak due to a Klebsiella pneumoniae strain harbouring KPC-2 and VIM-1 in a German university hospital, July 2010 to January 2011.en
dc.typeArticleen
dc.contributor.departmentInstitute of Medical Microbiology, University Hospital Essen, University of Duisburg- Essen, Essen, Germany. joerg.steinmann@uk-essen.deen
dc.identifier.journalEuro surveillance : bulletin européen sur les maladies transmissibles = European communicable disease bulletinen

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