The transcription factor FBI-1/OCZF/LRF is expressed in osteoclasts and regulates RANKL-induced osteoclast formation in vitro and in vivo.

2.50
Hdl Handle:
http://hdl.handle.net/10033/214592
Title:
The transcription factor FBI-1/OCZF/LRF is expressed in osteoclasts and regulates RANKL-induced osteoclast formation in vitro and in vivo.
Authors:
Kukita, Akiko; Kukita, Toshio; Nagata, Kengo; Teramachi, Junpei; Li, Yin-Ji; Yoshida, Hiroki; Miyamoto, Hiroshi; Gay, Steffen; Pessler, Frank; Shobuike, Takeo
Abstract:
Since transcription factors expressed in osteoclasts are possible targets for regulation of bone destruction in bone disorders, we investigated the expression of the transcription factor FBI-1/OCZF/LRF (in humans, factor that binds to inducer of short transcripts of human immunodeficiency virus type 1; in rats, osteoclast-derived zinc finger; in mice, leukemia/lymphoma-related factor) in patients with rheumatoid arthritis (RA), and assessed its role in osteoclastogenesis in vivo.
Affiliation:
Department of Microbiology, Faculty of Medicine, Saga University, Saga, Japan. kukita@cc.saga-u.ac.jp
Citation:
The transcription factor FBI-1/OCZF/LRF is expressed in osteoclasts and regulates RANKL-induced osteoclast formation in vitro and in vivo. 2011, 63 (9):2744-54 Arthritis Rheum.
Journal:
Arthritis and rheumatism
Issue Date:
Sep-2011
URI:
http://hdl.handle.net/10033/214592
DOI:
10.1002/art.30455
PubMed ID:
21590684
Type:
Article
Language:
en
ISSN:
1529-0131
Appears in Collections:
Publications of the department of epidemiology (EPID)

Full metadata record

DC FieldValue Language
dc.contributor.authorKukita, Akikoen
dc.contributor.authorKukita, Toshioen
dc.contributor.authorNagata, Kengoen
dc.contributor.authorTeramachi, Junpeien
dc.contributor.authorLi, Yin-Jien
dc.contributor.authorYoshida, Hirokien
dc.contributor.authorMiyamoto, Hiroshien
dc.contributor.authorGay, Steffenen
dc.contributor.authorPessler, Franken
dc.contributor.authorShobuike, Takeoen
dc.date.accessioned2012-03-07T10:39:20Z-
dc.date.available2012-03-07T10:39:20Z-
dc.date.issued2011-09-
dc.identifier.citationThe transcription factor FBI-1/OCZF/LRF is expressed in osteoclasts and regulates RANKL-induced osteoclast formation in vitro and in vivo. 2011, 63 (9):2744-54 Arthritis Rheum.en
dc.identifier.issn1529-0131-
dc.identifier.pmid21590684-
dc.identifier.doi10.1002/art.30455-
dc.identifier.urihttp://hdl.handle.net/10033/214592-
dc.description.abstractSince transcription factors expressed in osteoclasts are possible targets for regulation of bone destruction in bone disorders, we investigated the expression of the transcription factor FBI-1/OCZF/LRF (in humans, factor that binds to inducer of short transcripts of human immunodeficiency virus type 1; in rats, osteoclast-derived zinc finger; in mice, leukemia/lymphoma-related factor) in patients with rheumatoid arthritis (RA), and assessed its role in osteoclastogenesis in vivo.en
dc.language.isoenen
dc.subject.meshAnimalsen
dc.subject.meshArthritis, Experimentalen
dc.subject.meshArthritis, Rheumatoiden
dc.subject.meshBone Densityen
dc.subject.meshBone and Bonesen
dc.subject.meshCell Differentiationen
dc.subject.meshDNA-Binding Proteinsen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshMacrophagesen
dc.subject.meshMaleen
dc.subject.meshMiceen
dc.subject.meshMice, Transgenicen
dc.subject.meshOsteoblastsen
dc.subject.meshOsteoclastsen
dc.subject.meshRANK Liganden
dc.subject.meshRatsen
dc.subject.meshTranscription Factorsen
dc.titleThe transcription factor FBI-1/OCZF/LRF is expressed in osteoclasts and regulates RANKL-induced osteoclast formation in vitro and in vivo.en
dc.typeArticleen
dc.contributor.departmentDepartment of Microbiology, Faculty of Medicine, Saga University, Saga, Japan. kukita@cc.saga-u.ac.jpen
dc.identifier.journalArthritis and rheumatismen

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