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Bile Acids Specifically Increase Hepatitis C Virus RNA-Replication.
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|Title: ||Bile Acids Specifically Increase Hepatitis C Virus RNA-Replication.|
|Affiliation: ||Department of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover and the Helmholtz Centre for Infection Research, Hannover, Germany.|
|Citation: ||Bile Acids Specifically Increase Hepatitis C Virus RNA-Replication. 2012, 7 (4):e36029 PLoS ONE|
|Journal: ||PloS one|
|Issue Date: ||2012 |
|PubMed ID: ||22558311|
|Abstract: ||Hepatitis C virus (HCV) patients with high serum levels of bile acids (BAs) respond poorly to IFN therapy. BAs have been shown to increase RNA-replication of genotype 1 but not genotype 2a replicons. Since BAs modulate lipid metabolism including lipoprotein secretion and as HCV depends on lipids and lipoproteins during RNA-replication, virus production and cell entry, BAs may affect multiple steps of the HCV life cycle. Therefore, we analyzed the influence of BAs on individual steps of virus replication.|
|Appears in Collections: ||Publications of the Twincore unit Experimental Virology(EVIR)|
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|Chhatwal et al_final.pdf||Open Access publication||844Kb||Adobe PDF|
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