Bile Acids Specifically Increase Hepatitis C Virus RNA-Replication. - Helmholtz Zentrum für Infektionsforschung Repository

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Please use this identifier to cite or link to this item: http://hdl.handle.net/10033/222998
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Title:	Bile Acids Specifically Increase Hepatitis C Virus RNA-Replication.
Authors:	Chhatwal, Patrick Bankwitz, Dorothea Gentzsch, Juliane Frentzen, Anne Schult, Philipp Lohmann, Volker Pietschmann, Thomas
Affiliation:	Department of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover and the Helmholtz Centre for Infection Research, Hannover, Germany.
Citation:	Bile Acids Specifically Increase Hepatitis C Virus RNA-Replication. 2012, 7 (4):e36029 PLoS ONE
Journal:	PloS one
Issue Date:	2012
URI:	http://hdl.handle.net/10033/222998
DOI:	10.1371/journal.pone.0036029
PubMed ID:	22558311
Abstract:	Hepatitis C virus (HCV) patients with high serum levels of bile acids (BAs) respond poorly to IFN therapy. BAs have been shown to increase RNA-replication of genotype 1 but not genotype 2a replicons. Since BAs modulate lipid metabolism including lipoprotein secretion and as HCV depends on lipids and lipoproteins during RNA-replication, virus production and cell entry, BAs may affect multiple steps of the HCV life cycle. Therefore, we analyzed the influence of BAs on individual steps of virus replication.
Type:	Article
Language:	en
ISSN:	1932-6203
Appears in Collections:	Publications of the Twincore unit Experimental Virology(EVIR)

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