2.50
HDL Handle:
http://hdl.handle.net/10033/222998
Title:
Bile Acids Specifically Increase Hepatitis C Virus RNA-Replication.
Authors:
Chhatwal, Patrick; Bankwitz, Dorothea; Gentzsch, Juliane; Frentzen, Anne; Schult, Philipp; Lohmann, Volker; Pietschmann, Thomas
Abstract:
Hepatitis C virus (HCV) patients with high serum levels of bile acids (BAs) respond poorly to IFN therapy. BAs have been shown to increase RNA-replication of genotype 1 but not genotype 2a replicons. Since BAs modulate lipid metabolism including lipoprotein secretion and as HCV depends on lipids and lipoproteins during RNA-replication, virus production and cell entry, BAs may affect multiple steps of the HCV life cycle. Therefore, we analyzed the influence of BAs on individual steps of virus replication.
Affiliation:
Department of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover and the Helmholtz Centre for Infection Research, Hannover, Germany.
Citation:
Bile Acids Specifically Increase Hepatitis C Virus RNA-Replication. 2012, 7 (4):e36029 PLoS ONE
Journal:
PloS one
Issue Date:
2012
URI:
http://hdl.handle.net/10033/222998
DOI:
10.1371/journal.pone.0036029
PubMed ID:
22558311
Type:
Article
Language:
en
ISSN:
1932-6203
Appears in Collections:
Publications of the Twincore unit Experimental Virology(EVIR)

Full metadata record

DC FieldValueLanguage
dc.contributor.authorChhatwal, Patricken_GB
dc.contributor.authorBankwitz, Dorotheaen_GB
dc.contributor.authorGentzsch, Julianeen_GB
dc.contributor.authorFrentzen, Anneen_GB
dc.contributor.authorSchult, Philippen_GB
dc.contributor.authorLohmann, Volkeren_GB
dc.contributor.authorPietschmann, Thomasen_GB
dc.date.accessioned2012-05-10T09:24:05Z-
dc.date.available2012-05-10T09:24:05Z-
dc.date.issued2012-
dc.identifier.citationBile Acids Specifically Increase Hepatitis C Virus RNA-Replication. 2012, 7 (4):e36029 PLoS ONEen_GB
dc.identifier.issn1932-6203-
dc.identifier.pmid22558311-
dc.identifier.doi10.1371/journal.pone.0036029-
dc.identifier.urihttp://hdl.handle.net/10033/222998-
dc.description.abstractHepatitis C virus (HCV) patients with high serum levels of bile acids (BAs) respond poorly to IFN therapy. BAs have been shown to increase RNA-replication of genotype 1 but not genotype 2a replicons. Since BAs modulate lipid metabolism including lipoprotein secretion and as HCV depends on lipids and lipoproteins during RNA-replication, virus production and cell entry, BAs may affect multiple steps of the HCV life cycle. Therefore, we analyzed the influence of BAs on individual steps of virus replication.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to PloS oneen_GB
dc.titleBile Acids Specifically Increase Hepatitis C Virus RNA-Replication.en
dc.typeArticleen
dc.contributor.departmentDepartment of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover and the Helmholtz Centre for Infection Research, Hannover, Germany.en_GB
dc.identifier.journalPloS oneen_GB

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