Cyanoethylation of the glucans dextran and pullulan: Substitution pattern and formation of nanostructures and entrapment of magnetic nanoparticles.

2.50
Hdl Handle:
http://hdl.handle.net/10033/225583
Title:
Cyanoethylation of the glucans dextran and pullulan: Substitution pattern and formation of nanostructures and entrapment of magnetic nanoparticles.
Authors:
Fiege, Kathrin; Lünsdorf, Heinrich; Atarijabarzadeh, Sevil; Mischnick, Petra
Abstract:
Cyanoethylglucans with a degree of substitution in the range of 0.74 to 2.40 for dextran and 0.84 to 2.42 for pullulan were obtained by Michael addition of acrylonitrile to the glucans under various conditions. Products were thoroughly characterized, comprising elementary analysis, NMR and ATR-IR spectroscopy, and analysis of the substituent distribution in the glucosyl units by GC-FID and GC-MS of the constituting monosaccharide derivatives. Nanostructuring of the highly substituted cyanoethylpolysaccharides was performed by dialysis against a non-solvent. In the presence of ferromagnetic iron-oxide nanoparticles, multicore cyanoethylglucan-coated ferromagnetic nanoparticles were formed by selective entrapment. The specific interaction between cyano groups and iron could be proven. The size distribution and morphology of the nanoparticles were analyzed by dynamic light scattering (DLS), scanning electron microscopy (SEM) and energy-filtered transmission electron microscopy (EF-TEM) with parallel electron energy loss spectroscopy (PEELS).
Affiliation:
Institute for Food Chemistry, Technische Universität Braunschweig, Schleinitzstraße 20, D-38106 Braunschweig, Germany.
Citation:
Cyanoethylation of the glucans dextran and pullulan: Substitution pattern and formation of nanostructures and entrapment of magnetic nanoparticles. 2012, 8:551-66 Beilstein J Org Chem
Journal:
Beilstein journal of organic chemistry
Issue Date:
2012
URI:
http://hdl.handle.net/10033/225583
DOI:
10.3762/bjoc.8.63
PubMed ID:
22563354
Type:
Article
Language:
en
ISSN:
1860-5397
Appears in Collections:
publications of the research group vaccinology and applied microbiology (VAC)

Full metadata record

DC FieldValue Language
dc.contributor.authorFiege, Kathrinen_GB
dc.contributor.authorLünsdorf, Heinrichen_GB
dc.contributor.authorAtarijabarzadeh, Sevilen_GB
dc.contributor.authorMischnick, Petraen_GB
dc.date.accessioned2012-05-23T13:13:50Z-
dc.date.available2012-05-23T13:13:50Z-
dc.date.issued2012-
dc.identifier.citationCyanoethylation of the glucans dextran and pullulan: Substitution pattern and formation of nanostructures and entrapment of magnetic nanoparticles. 2012, 8:551-66 Beilstein J Org Chemen_GB
dc.identifier.issn1860-5397-
dc.identifier.pmid22563354-
dc.identifier.doi10.3762/bjoc.8.63-
dc.identifier.urihttp://hdl.handle.net/10033/225583-
dc.description.abstractCyanoethylglucans with a degree of substitution in the range of 0.74 to 2.40 for dextran and 0.84 to 2.42 for pullulan were obtained by Michael addition of acrylonitrile to the glucans under various conditions. Products were thoroughly characterized, comprising elementary analysis, NMR and ATR-IR spectroscopy, and analysis of the substituent distribution in the glucosyl units by GC-FID and GC-MS of the constituting monosaccharide derivatives. Nanostructuring of the highly substituted cyanoethylpolysaccharides was performed by dialysis against a non-solvent. In the presence of ferromagnetic iron-oxide nanoparticles, multicore cyanoethylglucan-coated ferromagnetic nanoparticles were formed by selective entrapment. The specific interaction between cyano groups and iron could be proven. The size distribution and morphology of the nanoparticles were analyzed by dynamic light scattering (DLS), scanning electron microscopy (SEM) and energy-filtered transmission electron microscopy (EF-TEM) with parallel electron energy loss spectroscopy (PEELS).en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Beilstein journal of organic chemistryen_GB
dc.titleCyanoethylation of the glucans dextran and pullulan: Substitution pattern and formation of nanostructures and entrapment of magnetic nanoparticles.en
dc.typeArticleen
dc.contributor.departmentInstitute for Food Chemistry, Technische Universität Braunschweig, Schleinitzstraße 20, D-38106 Braunschweig, Germany.en_GB
dc.identifier.journalBeilstein journal of organic chemistryen_GB

Related articles on PubMed

This item is licensed under a Creative Commons License
Creative Commons
All Items in HZI are protected by copyright, with all rights reserved, unless otherwise indicated.