2.50
Hdl Handle:
http://hdl.handle.net/10033/227676
Title:
Kinome analysis of receptor-induced phosphorylation in human natural killer cells.
Authors:
König, Sebastian; Nimtz, Manfred; Scheiter, Maxi; Ljunggren, Hans-Gustaf; Bryceson, Yenan T; Jänsch, Lothar
Abstract:
Natural killer (NK) cells contribute to the defense against infected and transformed cells through the engagement of multiple germline-encoded activation receptors. Stimulation of the Fc receptor CD16 alone is sufficient for NK cell activation, whereas other receptors, such as 2B4 (CD244) and DNAM-1 (CD226), act synergistically. After receptor engagement, protein kinases play a major role in signaling networks controlling NK cell effector functions. However, it has not been characterized systematically which of all kinases encoded by the human genome (kinome) are involved in NK cell activation.
Affiliation:
Department of Molecular Structural Biology, Helmholtz-Zentrum für Infektionsforschung, Braunschweig, Germany.
Citation:
Kinome analysis of receptor-induced phosphorylation in human natural killer cells. 2012, 7 (1):e29672 PLoS ONE
Journal:
PloS one
Issue Date:
2012
URI:
http://hdl.handle.net/10033/227676
DOI:
10.1371/journal.pone.0029672
PubMed ID:
22238634
Type:
Article
Language:
en
ISSN:
1932-6203
Appears in Collections:
Publications from Division of Molekulare Struktur Biologie (MOSB)

Full metadata record

DC FieldValue Language
dc.contributor.authorKönig, Sebastianen_GB
dc.contributor.authorNimtz, Manfreden_GB
dc.contributor.authorScheiter, Maxien_GB
dc.contributor.authorLjunggren, Hans-Gustafen_GB
dc.contributor.authorBryceson, Yenan Ten_GB
dc.contributor.authorJänsch, Lotharen_GB
dc.date.accessioned2012-06-06T14:18:27Z-
dc.date.available2012-06-06T14:18:27Z-
dc.date.issued2012-
dc.identifier.citationKinome analysis of receptor-induced phosphorylation in human natural killer cells. 2012, 7 (1):e29672 PLoS ONEen_GB
dc.identifier.issn1932-6203-
dc.identifier.pmid22238634-
dc.identifier.doi10.1371/journal.pone.0029672-
dc.identifier.urihttp://hdl.handle.net/10033/227676-
dc.description.abstractNatural killer (NK) cells contribute to the defense against infected and transformed cells through the engagement of multiple germline-encoded activation receptors. Stimulation of the Fc receptor CD16 alone is sufficient for NK cell activation, whereas other receptors, such as 2B4 (CD244) and DNAM-1 (CD226), act synergistically. After receptor engagement, protein kinases play a major role in signaling networks controlling NK cell effector functions. However, it has not been characterized systematically which of all kinases encoded by the human genome (kinome) are involved in NK cell activation.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to PloS oneen_GB
dc.subject.meshAmino Acid Sequenceen_GB
dc.subject.meshAnimalsen_GB
dc.subject.meshCells, Cultureden_GB
dc.subject.meshCluster Analysisen_GB
dc.subject.meshHumansen_GB
dc.subject.meshK562 Cellsen_GB
dc.subject.meshKiller Cells, Naturalen_GB
dc.subject.meshMiceen_GB
dc.subject.meshModels, Biologicalen_GB
dc.subject.meshPhosphoproteinsen_GB
dc.subject.meshPhosphorylationen_GB
dc.subject.meshPhosphotransferasesen_GB
dc.subject.meshPhylogenyen_GB
dc.subject.meshPrimary Cell Cultureen_GB
dc.subject.meshProteomeen_GB
dc.subject.meshReceptors, Cell Surfaceen_GB
dc.subject.meshReceptors, Fcen_GB
dc.titleKinome analysis of receptor-induced phosphorylation in human natural killer cells.en
dc.typeArticleen
dc.contributor.departmentDepartment of Molecular Structural Biology, Helmholtz-Zentrum für Infektionsforschung, Braunschweig, Germany.en_GB
dc.identifier.journalPloS oneen_GB

Related articles on PubMed

This item is licensed under a Creative Commons License
Creative Commons
All Items in HZI are protected by copyright, with all rights reserved, unless otherwise indicated.