Tumor necrosis factor alpha modulates the dynamics of the plasminogen-mediated early interaction between Bifidobacterium animalis subsp. lactis and human enterocytes.

2.50
Hdl Handle:
http://hdl.handle.net/10033/233551
Title:
Tumor necrosis factor alpha modulates the dynamics of the plasminogen-mediated early interaction between Bifidobacterium animalis subsp. lactis and human enterocytes.
Authors:
Centanni, Manuela; Bergmann, Simone; Turroni, Silvia; Hammerschmidt, Sven; Chhatwal, Gursharan Singh; Brigidi, Patrizia; Candela, Marco
Abstract:
The capacity to intervene with the host plasminogen system has recently been considered an important component in the interaction process between Bifidobacterium animalis subsp. lactis and the human host. However, its significance in the bifidobacterial microecology within the human gastrointestinal tract is still an open question. Here we demonstrate that human plasminogen favors the B. animalis subsp. lactis BI07 adhesion to HT29 cells. Prompting the HT29 cell capacity to activate plasminogen, tumor necrosis factor alpha (TNF-α) modulated the plasminogen-mediated bacterium-enterocyte interaction, reducing the bacterial adhesion to the enterocytes and enhancing migration to the luminal compartment.
Affiliation:
Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy.
Citation:
Tumor necrosis factor alpha modulates the dynamics of the plasminogen-mediated early interaction between Bifidobacterium animalis subsp. lactis and human enterocytes. 2012, 78 (7):2465-9 Appl. Environ. Microbiol.
Journal:
Applied and environmental microbiology
Issue Date:
Apr-2012
URI:
http://hdl.handle.net/10033/233551
DOI:
10.1128/AEM.07883-11
PubMed ID:
22287006
Type:
Article
Language:
en
ISSN:
1098-5336
Appears in Collections:
Publications of Dept. Medizinische Mikrobiologie (MMIK)

Full metadata record

DC FieldValue Language
dc.contributor.authorCentanni, Manuelaen_GB
dc.contributor.authorBergmann, Simoneen_GB
dc.contributor.authorTurroni, Silviaen_GB
dc.contributor.authorHammerschmidt, Svenen_GB
dc.contributor.authorChhatwal, Gursharan Singhen_GB
dc.contributor.authorBrigidi, Patriziaen_GB
dc.contributor.authorCandela, Marcoen_GB
dc.date.accessioned2012-07-13T09:12:54Z-
dc.date.available2012-07-13T09:12:54Z-
dc.date.issued2012-04-
dc.identifier.citationTumor necrosis factor alpha modulates the dynamics of the plasminogen-mediated early interaction between Bifidobacterium animalis subsp. lactis and human enterocytes. 2012, 78 (7):2465-9 Appl. Environ. Microbiol.en_GB
dc.identifier.issn1098-5336-
dc.identifier.pmid22287006-
dc.identifier.doi10.1128/AEM.07883-11-
dc.identifier.urihttp://hdl.handle.net/10033/233551-
dc.description.abstractThe capacity to intervene with the host plasminogen system has recently been considered an important component in the interaction process between Bifidobacterium animalis subsp. lactis and the human host. However, its significance in the bifidobacterial microecology within the human gastrointestinal tract is still an open question. Here we demonstrate that human plasminogen favors the B. animalis subsp. lactis BI07 adhesion to HT29 cells. Prompting the HT29 cell capacity to activate plasminogen, tumor necrosis factor alpha (TNF-α) modulated the plasminogen-mediated bacterium-enterocyte interaction, reducing the bacterial adhesion to the enterocytes and enhancing migration to the luminal compartment.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Applied and environmental microbiologyen_GB
dc.titleTumor necrosis factor alpha modulates the dynamics of the plasminogen-mediated early interaction between Bifidobacterium animalis subsp. lactis and human enterocytes.en
dc.typeArticleen
dc.contributor.departmentDepartment of Pharmaceutical Sciences, University of Bologna, Bologna, Italy.en_GB
dc.identifier.journalApplied and environmental microbiologyen_GB

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