TCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells.

2.50
HDL Handle:
http://hdl.handle.net/10033/233572
Title:
TCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells.
Authors:
Warnecke, Nicole; Poltorak, Mateusz; Kowtharapu, Bhavani S; Arndt, Boerge; Stone, James C; Schraven, Burkhart; Simeoni, Luca
Abstract:
Sos proteins are ubiquitously expressed activators of Ras. Lymphoid cells also express RasGRP1, another Ras activator. Sos and RasGRP1 are thought to cooperatively control full Ras activation upon T-cell receptor triggering. Using RNA interference, we evaluated whether this mechanism operates in primary human T cells. We found that T-cell antigen receptor (TCR)-mediated Erk activation requires RasGRP1, but not Grb2/Sos. Conversely, Grb2/Sos—but not RasGRP1—are required for IL2-mediated Erk activation. Thus, RasGRP1 and Grb2/Sos are insulators of signals that lead to Ras activation induced by different stimuli, rather than cooperating downstream of the TCR.
Affiliation:
Institute of Molecular and Clinical Immunology, Otto-von-Guericke University, Leipziger Strasse 44, Magdeburg 39120, Germany.
Citation:
TCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells. 2012, 13 (4):386-91 EMBO Rep.
Journal:
EMBO reports
Issue Date:
Apr-2012
URI:
http://hdl.handle.net/10033/233572
DOI:
10.1038/embor.2012.17
PubMed ID:
22344067
Type:
Article
Language:
en
ISSN:
1469-3178
Appears in Collections:
publications of the department of immunocontrol (IMMK)

Full metadata record

DC FieldValueLanguage
dc.contributor.authorWarnecke, Nicoleen_GB
dc.contributor.authorPoltorak, Mateuszen_GB
dc.contributor.authorKowtharapu, Bhavani Sen_GB
dc.contributor.authorArndt, Boergeen_GB
dc.contributor.authorStone, James Cen_GB
dc.contributor.authorSchraven, Burkharten_GB
dc.contributor.authorSimeoni, Lucaen_GB
dc.date.accessioned2012-07-13T09:44:08Z-
dc.date.available2012-07-13T09:44:08Z-
dc.date.issued2012-04-
dc.identifier.citationTCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells. 2012, 13 (4):386-91 EMBO Rep.en_GB
dc.identifier.issn1469-3178-
dc.identifier.pmid22344067-
dc.identifier.doi10.1038/embor.2012.17-
dc.identifier.urihttp://hdl.handle.net/10033/233572-
dc.description.abstractSos proteins are ubiquitously expressed activators of Ras. Lymphoid cells also express RasGRP1, another Ras activator. Sos and RasGRP1 are thought to cooperatively control full Ras activation upon T-cell receptor triggering. Using RNA interference, we evaluated whether this mechanism operates in primary human T cells. We found that T-cell antigen receptor (TCR)-mediated Erk activation requires RasGRP1, but not Grb2/Sos. Conversely, Grb2/Sos—but not RasGRP1—are required for IL2-mediated Erk activation. Thus, RasGRP1 and Grb2/Sos are insulators of signals that lead to Ras activation induced by different stimuli, rather than cooperating downstream of the TCR.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to EMBO reportsen_GB
dc.titleTCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells.en
dc.typeArticleen
dc.contributor.departmentInstitute of Molecular and Clinical Immunology, Otto-von-Guericke University, Leipziger Strasse 44, Magdeburg 39120, Germany.en_GB
dc.identifier.journalEMBO reportsen_GB
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