Genome-wide analysis of the mouse lung transcriptome reveals novel molecular gene interaction networks and cell-specific expression signatures.

2.50
Hdl Handle:
http://hdl.handle.net/10033/235971
Title:
Genome-wide analysis of the mouse lung transcriptome reveals novel molecular gene interaction networks and cell-specific expression signatures.
Authors:
Alberts, Rudi; Lu, Lu; Williams, Robert W; Schughart, Klaus
Abstract:
The lung is critical in surveillance and initial defense against pathogens. In humans, as in mice, individual genetic differences strongly modulate pulmonary responses to infectious agents, severity of lung disease, and potential allergic reactions. In a first step towards understanding genetic predisposition and pulmonary molecular networks that underlie individual differences in disease vulnerability, we performed a global analysis of normative lung gene expression levels in inbred mouse strains and a large family of BXD strains that are widely used for systems genetics. Our goal is to provide a key community resource on the genetics of the normative lung transcriptome that can serve as a foundation for experimental analysis and allow predicting genetic predisposition and response to pathogens, allergens, and xenobiotics.
Affiliation:
Department of Infection Genetics, University of Veterinary Medicine Hannover, Inhoffenstr, Braunschweig, Germany.
Citation:
Genome-wide analysis of the mouse lung transcriptome reveals novel molecular gene interaction networks and cell-specific expression signatures. 2011, 12:61 Respir. Res.
Journal:
Respiratory research
Issue Date:
2011
URI:
http://hdl.handle.net/10033/235971
DOI:
10.1186/1465-9921-12-61
PubMed ID:
21535883
Type:
Article
Language:
en
ISSN:
1465-993X
Appears in Collections:
Publications of JRG Infection Genetics (INFG)

Full metadata record

DC FieldValue Language
dc.contributor.authorAlberts, Rudien_GB
dc.contributor.authorLu, Luen_GB
dc.contributor.authorWilliams, Robert Wen_GB
dc.contributor.authorSchughart, Klausen_GB
dc.date.accessioned2012-07-27T12:11:15Z-
dc.date.available2012-07-27T12:11:15Z-
dc.date.issued2011-
dc.identifier.citationGenome-wide analysis of the mouse lung transcriptome reveals novel molecular gene interaction networks and cell-specific expression signatures. 2011, 12:61 Respir. Res.en_GB
dc.identifier.issn1465-993X-
dc.identifier.pmid21535883-
dc.identifier.doi10.1186/1465-9921-12-61-
dc.identifier.urihttp://hdl.handle.net/10033/235971-
dc.description.abstractThe lung is critical in surveillance and initial defense against pathogens. In humans, as in mice, individual genetic differences strongly modulate pulmonary responses to infectious agents, severity of lung disease, and potential allergic reactions. In a first step towards understanding genetic predisposition and pulmonary molecular networks that underlie individual differences in disease vulnerability, we performed a global analysis of normative lung gene expression levels in inbred mouse strains and a large family of BXD strains that are widely used for systems genetics. Our goal is to provide a key community resource on the genetics of the normative lung transcriptome that can serve as a foundation for experimental analysis and allow predicting genetic predisposition and response to pathogens, allergens, and xenobiotics.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Respiratory researchen_GB
dc.subject.meshAnimalsen_GB
dc.subject.meshB-Lymphocytesen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshGene Expression Profilingen_GB
dc.subject.meshGene Expression Regulationen_GB
dc.subject.meshGene Regulatory Networksen_GB
dc.subject.meshGenetic Predisposition to Diseaseen_GB
dc.subject.meshHeredityen_GB
dc.subject.meshLod Scoreen_GB
dc.subject.meshLungen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiceen_GB
dc.subject.meshMice, Inbred BALB Cen_GB
dc.subject.meshMice, Inbred C57BLen_GB
dc.subject.meshMice, Inbred DBAen_GB
dc.subject.meshOligonucleotide Array Sequence Analysisen_GB
dc.subject.meshPhenotypeen_GB
dc.subject.meshQuantitative Trait, Heritableen_GB
dc.subject.meshRNA, Messengeren_GB
dc.subject.meshSpecies Specificityen_GB
dc.subject.meshT-Lymphocytesen_GB
dc.titleGenome-wide analysis of the mouse lung transcriptome reveals novel molecular gene interaction networks and cell-specific expression signatures.en
dc.typeArticleen
dc.contributor.departmentDepartment of Infection Genetics, University of Veterinary Medicine Hannover, Inhoffenstr, Braunschweig, Germany.en_GB
dc.identifier.journalRespiratory researchen_GB

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