| Title: | More than just a metabolic regulator--elucidation and validation of new targets of PdhR in Escherichia coli. |
| Authors: | Göhler, Anna-Katharina
Kökpinar, Öznur
Schmidt-Heck, Wolfgang
Geffers, Robert
Guthke, Reinhard
Rinas, Ursula
Schuster, Stefan
Jahreis, Knut
Kaleta, Christoph |
| Affiliation: | Department of Genetics, University of Osnabrück, Osnabrück, Germany. |
| Citation: | More than just a metabolic regulator--elucidation and validation of new targets of PdhR in Escherichia coli. 2011, 5:197 BMC Syst Biol |
| Journal: | BMC systems biology |
| Issue Date: | 2011 |
| URI: | http://hdl.handle.net/10033/236989 |
| DOI: | 10.1186/1752-0509-5-197 |
| PubMed ID: | 22168595 |
| Abstract: | The pyruvate dehydrogenase regulator protein (PdhR) of Escherichia coli acts as a transcriptional regulator in a pyruvate dependent manner to control central metabolic fluxes. However, the complete PdhR regulon has not yet been uncovered. To achieve an extended understanding of its gene regulatory network, we combined large-scale network inference and experimental verification of results obtained by a systems biology approach. |
| Type: | Article |
| Language: | en |
| MeSH: | Escherichia coli
Escherichia coli Proteins
Gene Expression Regulation, Bacterial
Gene Regulatory Networks
Genes, Bacterial
Metabolic Networks and Pathways
Regulon
Repressor Proteins
Systems Biology |
| ISSN: | 1752-0509 |
| Appears in Collections: | Publications of the RG Rekombinante Proteinexpression (RPEX)
|
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