2.50
HDL Handle:
http://hdl.handle.net/10033/236989
Title:
More than just a metabolic regulator--elucidation and validation of new targets of PdhR in Escherichia coli.
Authors:
Göhler, Anna-Katharina; Kökpinar, Öznur; Schmidt-Heck, Wolfgang; Geffers, Robert; Guthke, Reinhard; Rinas, Ursula; Schuster, Stefan; Jahreis, Knut; Kaleta, Christoph
Abstract:
The pyruvate dehydrogenase regulator protein (PdhR) of Escherichia coli acts as a transcriptional regulator in a pyruvate dependent manner to control central metabolic fluxes. However, the complete PdhR regulon has not yet been uncovered. To achieve an extended understanding of its gene regulatory network, we combined large-scale network inference and experimental verification of results obtained by a systems biology approach.
Affiliation:
Department of Genetics, University of Osnabrück, Osnabrück, Germany.
Citation:
More than just a metabolic regulator--elucidation and validation of new targets of PdhR in Escherichia coli. 2011, 5:197 BMC Syst Biol
Journal:
BMC systems biology
Issue Date:
2011
URI:
http://hdl.handle.net/10033/236989
DOI:
10.1186/1752-0509-5-197
PubMed ID:
22168595
Type:
Article
Language:
en
ISSN:
1752-0509
Appears in Collections:
Publications of the RG Rekombinante Proteinexpression (RPEX)

Full metadata record

DC FieldValueLanguage
dc.contributor.authorGöhler, Anna-Katharinaen_GB
dc.contributor.authorKökpinar, Öznuren_GB
dc.contributor.authorSchmidt-Heck, Wolfgangen_GB
dc.contributor.authorGeffers, Roberten_GB
dc.contributor.authorGuthke, Reinharden_GB
dc.contributor.authorRinas, Ursulaen_GB
dc.contributor.authorSchuster, Stefanen_GB
dc.contributor.authorJahreis, Knuten_GB
dc.contributor.authorKaleta, Christophen_GB
dc.date.accessioned2012-08-02T10:34:07Z-
dc.date.available2012-08-02T10:34:07Z-
dc.date.issued2011-
dc.identifier.citationMore than just a metabolic regulator--elucidation and validation of new targets of PdhR in Escherichia coli. 2011, 5:197 BMC Syst Biolen_GB
dc.identifier.issn1752-0509-
dc.identifier.pmid22168595-
dc.identifier.doi10.1186/1752-0509-5-197-
dc.identifier.urihttp://hdl.handle.net/10033/236989-
dc.description.abstractThe pyruvate dehydrogenase regulator protein (PdhR) of Escherichia coli acts as a transcriptional regulator in a pyruvate dependent manner to control central metabolic fluxes. However, the complete PdhR regulon has not yet been uncovered. To achieve an extended understanding of its gene regulatory network, we combined large-scale network inference and experimental verification of results obtained by a systems biology approach.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to BMC systems biologyen_GB
dc.subject.meshEscherichia colien_GB
dc.subject.meshEscherichia coli Proteinsen_GB
dc.subject.meshGene Expression Regulation, Bacterialen_GB
dc.subject.meshGene Regulatory Networksen_GB
dc.subject.meshGenes, Bacterialen_GB
dc.subject.meshMetabolic Networks and Pathwaysen_GB
dc.subject.meshRegulonen_GB
dc.subject.meshRepressor Proteinsen_GB
dc.subject.meshSystems Biologyen_GB
dc.titleMore than just a metabolic regulator--elucidation and validation of new targets of PdhR in Escherichia coli.en
dc.typeArticleen
dc.contributor.departmentDepartment of Genetics, University of Osnabrück, Osnabrück, Germany.en_GB
dc.identifier.journalBMC systems biologyen_GB

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