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Novel standards in the measurement of rat insulin granules combining electron microscopy, high-content image analysis and in silico modelling.
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| Title: | Novel standards in the measurement of rat insulin granules combining electron microscopy, high-content image analysis and in silico modelling. |
| Authors: | Fava, E
Dehghany, J
Ouwendijk, J
Müller, A
Niederlein, A
Verkade, P
Meyer-Hermann, M
Solimena, M |
| Affiliation: | Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany. |
| Citation: | Novel standards in the measurement of rat insulin granules combining electron microscopy, high-content image analysis and in silico modelling. 2012, 55 (4):1013-23 Diabetologia |
| Journal: | Diabetologia |
| Issue Date: | Apr-2012 |
| URI: | http://hdl.handle.net/10033/237053 |
| DOI: | 10.1007/s00125-011-2438-4 |
| PubMed ID: | 22252472 |
| Abstract: | Knowledge of number, size and content of insulin secretory granules is pivotal for understanding the physiology of pancreatic beta cells. Here we re-evaluated key structural features of rat beta cells, including insulin granule size, number and distribution as well as cell size. |
| Type: | Article |
| Language: | en |
| ISSN: | 1432-0428 |
| Appears in Collections: | publications of the division system immunology (SIMM)
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