Serum microRNA-21 as marker for necroinflammation in hepatitis C patients with and without hepatocellular carcinoma.

2.50
Hdl Handle:
http://hdl.handle.net/10033/237153
Title:
Serum microRNA-21 as marker for necroinflammation in hepatitis C patients with and without hepatocellular carcinoma.
Authors:
Bihrer, Verena; Waidmann, Oliver; Friedrich-Rust, Mireen; Forestier, Nicole; Susser, Simone; Haupenthal, Jörg; Welker, Martin; Shi, Ying; Peveling-Oberhag, Jan; Polta, Andreas; von Wagner, Michael; Radeke, Heinfried H; Sarrazin, Christoph; Trojan, Jörg; Zeuzem, Stefan; Kronenberger, Bernd; Piiper, Albrecht
Abstract:
MicroRNA-21 (miR-21) is up-regulated in tumor tissue of patients with malignant diseases, including hepatocellular carcinoma (HCC). Elevated concentrations of miR-21 have also been found in sera or plasma from patients with malignancies, rendering it an interesting candidate as serum/plasma marker for malignancies. Here we correlated serum miR-21 levels with clinical parameters in patients with different stages of chronic hepatitis C virus infection (CHC) and CHC-associated HCC.
Affiliation:
Department of Medicine I, University of Frankfurt/M., Frankfurt, Germany.
Citation:
Serum microRNA-21 as marker for necroinflammation in hepatitis C patients with and without hepatocellular carcinoma. 2011, 6 (10):e26971 PLoS ONE
Journal:
PloS one
Issue Date:
2011
URI:
http://hdl.handle.net/10033/237153
DOI:
10.1371/journal.pone.0026971
PubMed ID:
22066022
Type:
Article
Language:
en
ISSN:
1932-6203
Appears in Collections:
Publications of the divsion Wirkstoffdesign und Optimierung (DDOP)

Full metadata record

DC FieldValue Language
dc.contributor.authorBihrer, Verenaen_GB
dc.contributor.authorWaidmann, Oliveren_GB
dc.contributor.authorFriedrich-Rust, Mireenen_GB
dc.contributor.authorForestier, Nicoleen_GB
dc.contributor.authorSusser, Simoneen_GB
dc.contributor.authorHaupenthal, Jörgen_GB
dc.contributor.authorWelker, Martinen_GB
dc.contributor.authorShi, Yingen_GB
dc.contributor.authorPeveling-Oberhag, Janen_GB
dc.contributor.authorPolta, Andreasen_GB
dc.contributor.authorvon Wagner, Michaelen_GB
dc.contributor.authorRadeke, Heinfried Hen_GB
dc.contributor.authorSarrazin, Christophen_GB
dc.contributor.authorTrojan, Jörgen_GB
dc.contributor.authorZeuzem, Stefanen_GB
dc.contributor.authorKronenberger, Bernden_GB
dc.contributor.authorPiiper, Albrechten_GB
dc.date.accessioned2012-08-03T12:25:14Z-
dc.date.available2012-08-03T12:25:14Z-
dc.date.issued2011-
dc.identifier.citationSerum microRNA-21 as marker for necroinflammation in hepatitis C patients with and without hepatocellular carcinoma. 2011, 6 (10):e26971 PLoS ONEen_GB
dc.identifier.issn1932-6203-
dc.identifier.pmid22066022-
dc.identifier.doi10.1371/journal.pone.0026971-
dc.identifier.urihttp://hdl.handle.net/10033/237153-
dc.description.abstractMicroRNA-21 (miR-21) is up-regulated in tumor tissue of patients with malignant diseases, including hepatocellular carcinoma (HCC). Elevated concentrations of miR-21 have also been found in sera or plasma from patients with malignancies, rendering it an interesting candidate as serum/plasma marker for malignancies. Here we correlated serum miR-21 levels with clinical parameters in patients with different stages of chronic hepatitis C virus infection (CHC) and CHC-associated HCC.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to PloS oneen_GB
dc.subject.meshAlanine Transaminaseen_GB
dc.subject.meshAspartate Aminotransferasesen_GB
dc.subject.meshBilirubinen_GB
dc.subject.meshBiological Markersen_GB
dc.subject.meshCarcinoma, Hepatocellularen_GB
dc.subject.meshCohort Studiesen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHepatitis C, Chronicen_GB
dc.subject.meshHumansen_GB
dc.subject.meshInflammationen_GB
dc.subject.meshLiver Neoplasmsen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMicroRNAsen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshMultivariate Analysisen_GB
dc.subject.meshNecrosisen_GB
dc.subject.meshReproducibility of Resultsen_GB
dc.subject.meshSerum Albuminen_GB
dc.subject.meshgamma-Glutamyltransferaseen_GB
dc.titleSerum microRNA-21 as marker for necroinflammation in hepatitis C patients with and without hepatocellular carcinoma.en
dc.typeArticleen
dc.contributor.departmentDepartment of Medicine I, University of Frankfurt/M., Frankfurt, Germany.en_GB
dc.identifier.journalPloS oneen_GB

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