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Serum microRNA-21 as marker for necroinflammation in hepatitis C patients with and without hepatocellular carcinoma.
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| Title: | Serum microRNA-21 as marker for necroinflammation in hepatitis C patients with and without hepatocellular carcinoma. |
| Authors: | Bihrer, Verena
Waidmann, Oliver
Friedrich-Rust, Mireen
Forestier, Nicole
Susser, Simone
Haupenthal, Jörg
Welker, Martin
Shi, Ying
Peveling-Oberhag, Jan
Polta, Andreas
von Wagner, Michael
Radeke, Heinfried H
Sarrazin, Christoph
Trojan, Jörg
Zeuzem, Stefan
Kronenberger, Bernd
Piiper, Albrecht |
| Affiliation: | Department of Medicine I, University of Frankfurt/M., Frankfurt, Germany. |
| Citation: | Serum microRNA-21 as marker for necroinflammation in hepatitis C patients with and without hepatocellular carcinoma. 2011, 6 (10):e26971 PLoS ONE |
| Journal: | PloS one |
| Issue Date: | 2011 |
| URI: | http://hdl.handle.net/10033/237153 |
| DOI: | 10.1371/journal.pone.0026971 |
| PubMed ID: | 22066022 |
| Abstract: | MicroRNA-21 (miR-21) is up-regulated in tumor tissue of patients with malignant diseases, including hepatocellular carcinoma (HCC). Elevated concentrations of miR-21 have also been found in sera or plasma from patients with malignancies, rendering it an interesting candidate as serum/plasma marker for malignancies. Here we correlated serum miR-21 levels with clinical parameters in patients with different stages of chronic hepatitis C virus infection (CHC) and CHC-associated HCC. |
| Type: | Article |
| Language: | en |
| MeSH: | Alanine Transaminase
Aspartate Aminotransferases
Bilirubin
Biological Markers
Carcinoma, Hepatocellular
Cohort Studies
Female
Hepatitis C, Chronic
Humans
Inflammation
Liver Neoplasms
Male
MicroRNAs
Middle Aged
Multivariate Analysis
Necrosis
Reproducibility of Results
Serum Albumin
gamma-Glutamyltransferase |
| ISSN: | 1932-6203 |
| Appears in Collections: | Publications of the divsion Wirkstoffdesign und Optimierung (DDOP)
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| Related articles on PubMed |  | Serum miR-122 as a biomarker of necroinflammation in patients with chronic hepatitis C virus infection.Bihrer V, Friedrich-Rust M, Kronenberger B, Forestier N, Haupenthal J, Shi Y, Peveling-Oberhag J, Radeke HH, Sarrazin C, Herrmann E, Zeuzem S, Waidmann O, Piiper A 2011 Sep |
| | | | | | See all 172 articles |
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