E-N-cadherin heterodimers define novel adherens junctions connecting endoderm-derived cells.

2.50
Hdl Handle:
http://hdl.handle.net/10033/237912
Title:
E-N-cadherin heterodimers define novel adherens junctions connecting endoderm-derived cells.
Authors:
Straub, Beate K; Rickelt, Steffen; Zimbelmann, Ralf; Grund, Christine; Kuhn, Caecilia; Iken, Marcus; Ott, Michael; Schirmacher, Peter; Franke, Werner W
Abstract:
Intercellular junctions play a pivotal role in tissue development and function and also in tumorigenesis. In epithelial cells, decrease or loss of E-cadherin, the hallmark molecule of adherens junctions (AJs), and increase of N-cadherin are widely thought to promote carcinoma progression and metastasis. In this paper, we show that this "cadherin switch" hypothesis does not hold for diverse endoderm-derived cells and cells of tumors derived from them. We show that the cadherins in a major portion of AJs in these cells can be chemically cross-linked in E-N heterodimers. We also show that cells possessing E-N heterodimer AJs can form semistable hemihomotypic AJs with purely N-cadherin-based AJs of mesenchymally derived cells, including stroma cells. We conclude that these heterodimers are the major AJ constituents of several endoderm-derived tissues and tumors and that the prevailing concept of antagonistic roles of these two cadherins in developmental and tumor biology has to be reconsidered.
Affiliation:
Helmholtz Group for Cell Biology, German Cancer Research Center, 69120 Heidelberg, Germany.
Citation:
E-N-cadherin heterodimers define novel adherens junctions connecting endoderm-derived cells. 2011, 195 (5):873-87 J. Cell Biol.
Journal:
The Journal of cell biology
Issue Date:
28-Nov-2011
URI:
http://hdl.handle.net/10033/237912
DOI:
10.1083/jcb.201106023
PubMed ID:
22105347
Type:
Article
Language:
en
ISSN:
1540-8140
Appears in Collections:
Publications of the TwinCore unit experimental Infectionresearch(EXPI)

Full metadata record

DC FieldValue Language
dc.contributor.authorStraub, Beate Ken_GB
dc.contributor.authorRickelt, Steffenen_GB
dc.contributor.authorZimbelmann, Ralfen_GB
dc.contributor.authorGrund, Christineen_GB
dc.contributor.authorKuhn, Caeciliaen_GB
dc.contributor.authorIken, Marcusen_GB
dc.contributor.authorOtt, Michaelen_GB
dc.contributor.authorSchirmacher, Peteren_GB
dc.contributor.authorFranke, Werner Wen_GB
dc.date.accessioned2012-08-09T10:34:14Z-
dc.date.available2012-08-09T10:34:14Z-
dc.date.issued2011-11-28-
dc.identifier.citationE-N-cadherin heterodimers define novel adherens junctions connecting endoderm-derived cells. 2011, 195 (5):873-87 J. Cell Biol.en_GB
dc.identifier.issn1540-8140-
dc.identifier.pmid22105347-
dc.identifier.doi10.1083/jcb.201106023-
dc.identifier.urihttp://hdl.handle.net/10033/237912-
dc.description.abstractIntercellular junctions play a pivotal role in tissue development and function and also in tumorigenesis. In epithelial cells, decrease or loss of E-cadherin, the hallmark molecule of adherens junctions (AJs), and increase of N-cadherin are widely thought to promote carcinoma progression and metastasis. In this paper, we show that this "cadherin switch" hypothesis does not hold for diverse endoderm-derived cells and cells of tumors derived from them. We show that the cadherins in a major portion of AJs in these cells can be chemically cross-linked in E-N heterodimers. We also show that cells possessing E-N heterodimer AJs can form semistable hemihomotypic AJs with purely N-cadherin-based AJs of mesenchymally derived cells, including stroma cells. We conclude that these heterodimers are the major AJ constituents of several endoderm-derived tissues and tumors and that the prevailing concept of antagonistic roles of these two cadherins in developmental and tumor biology has to be reconsidered.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to The Journal of cell biologyen_GB
dc.subject.meshAdherens Junctionsen_GB
dc.subject.meshAnimalsen_GB
dc.subject.meshCadherinsen_GB
dc.subject.meshCattleen_GB
dc.subject.meshCell Adhesionen_GB
dc.subject.meshEndodermen_GB
dc.subject.meshHumansen_GB
dc.subject.meshMiceen_GB
dc.subject.meshRatsen_GB
dc.subject.meshSwineen_GB
dc.subject.meshTumor Cells, Cultureden_GB
dc.titleE-N-cadherin heterodimers define novel adherens junctions connecting endoderm-derived cells.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Group for Cell Biology, German Cancer Research Center, 69120 Heidelberg, Germany.en_GB
dc.identifier.journalThe Journal of cell biologyen_GB
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