Pullularins E and F, Two New Peptides from the Endophytic Fungus Bionectria ochroleuca Isolated from the Mangrove Plant Sonneratia caseolaris.

2.50
Hdl Handle:
http://hdl.handle.net/10033/239471
Title:
Pullularins E and F, Two New Peptides from the Endophytic Fungus Bionectria ochroleuca Isolated from the Mangrove Plant Sonneratia caseolaris.
Authors:
Ebrahim, Weaam; Kjer, Julia; El Amrani, Mustapha; Wray, Victor; Lin, Wenhan; Ebel, Rainer; Lai, Daowan; Proksch, Peter
Abstract:
Chemical investigation of the EtOAc extract of the endophytic fungus Bionectria ochroleuca, isolated from the inner leaf tissues of the plant Sonneratia caseolaris (Sonneratiaceae) from Hainan island (China), yielded two new peptides, pullularins E and F (1 and 2) together with three known compounds (3-5). The structures of the new compounds were unambiguously determined on the basis of one- and two-dimensional NMR spectroscopy as well as by high-resolution mass spectrometry. The absolute configurations of amino acids were determined by HPLC analysis of acid hydrolysates using Marfey's method. The isolated compounds exhibited pronounced to moderate cytotoxic activity against the mouse lymphoma cells (L5178Y) with EC(50) values ranging between 0.1 and 6.7 µg/mL.
Affiliation:
Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University, Universitaetsstrasse 1, D-40225 Duesseldorf, Germany; Email: weel-001@uni-duesseldorf.de or weaamnabil@mans.edu.eg (W.E.); jacob.julia@web.de (J.K.); mustapha.elamrani@uni-duesseldorf.de (M.E.A.).
Citation:
Pullularins E and F, Two New Peptides from the Endophytic Fungus Bionectria ochroleuca Isolated from the Mangrove Plant Sonneratia caseolaris. 2012, 10 (5):1081-91 Mar Drugs
Journal:
Marine drugs
Issue Date:
May-2012
URI:
http://hdl.handle.net/10033/239471
DOI:
10.3390/md10051081
PubMed ID:
22822358
Type:
Article
Language:
en
ISSN:
1660-3397
Appears in Collections:
Publications from RG Biophysical Analysis (BA)

Full metadata record

DC FieldValue Language
dc.contributor.authorEbrahim, Weaamen_GB
dc.contributor.authorKjer, Juliaen_GB
dc.contributor.authorEl Amrani, Mustaphaen_GB
dc.contributor.authorWray, Victoren_GB
dc.contributor.authorLin, Wenhanen_GB
dc.contributor.authorEbel, Raineren_GB
dc.contributor.authorLai, Daowanen_GB
dc.contributor.authorProksch, Peteren_GB
dc.date.accessioned2012-08-22T13:01:10Z-
dc.date.available2012-08-22T13:01:10Z-
dc.date.issued2012-05-
dc.identifier.citationPullularins E and F, Two New Peptides from the Endophytic Fungus Bionectria ochroleuca Isolated from the Mangrove Plant Sonneratia caseolaris. 2012, 10 (5):1081-91 Mar Drugsen_GB
dc.identifier.issn1660-3397-
dc.identifier.pmid22822358-
dc.identifier.doi10.3390/md10051081-
dc.identifier.urihttp://hdl.handle.net/10033/239471-
dc.description.abstractChemical investigation of the EtOAc extract of the endophytic fungus Bionectria ochroleuca, isolated from the inner leaf tissues of the plant Sonneratia caseolaris (Sonneratiaceae) from Hainan island (China), yielded two new peptides, pullularins E and F (1 and 2) together with three known compounds (3-5). The structures of the new compounds were unambiguously determined on the basis of one- and two-dimensional NMR spectroscopy as well as by high-resolution mass spectrometry. The absolute configurations of amino acids were determined by HPLC analysis of acid hydrolysates using Marfey's method. The isolated compounds exhibited pronounced to moderate cytotoxic activity against the mouse lymphoma cells (L5178Y) with EC(50) values ranging between 0.1 and 6.7 µg/mL.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Marine drugsen_GB
dc.titlePullularins E and F, Two New Peptides from the Endophytic Fungus Bionectria ochroleuca Isolated from the Mangrove Plant Sonneratia caseolaris.en
dc.typeArticleen
dc.contributor.departmentInstitute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University, Universitaetsstrasse 1, D-40225 Duesseldorf, Germany; Email: weel-001@uni-duesseldorf.de or weaamnabil@mans.edu.eg (W.E.); jacob.julia@web.de (J.K.); mustapha.elamrani@uni-duesseldorf.de (M.E.A.).en_GB
dc.identifier.journalMarine drugsen_GB

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