2.50
Hdl Handle:
http://hdl.handle.net/10033/244999
Title:
Programmable bacterial catalysis - designing cells for biosynthesis of value-added compounds.
Authors:
Lam, Carolyn M C; Suárez Diez, María; Godinho, Miguel; Martins Dos Santos, Vítor A P
Abstract:
Bacteria have long been used for the synthesis of a wide range of useful proteins and compounds. The developments of new bioprocesses and improvements of existing strategies for syntheses of valuable products in various bacterial cell hosts have their own challenges and limitations. The field of synthetic biology has combined knowledge from different science and engineering disciplines and facilitated the advancement of novel biological components which has inspired the design of targeted biosynthesis. Here we discuss recent advances in synthetic biology with relevance to biosynthesis in bacteria and the applications of computational algorithms and tools for manipulation of cellular components. Continuous improvements are necessary to keep up with increasing demands in terms of complexity, scale, and predictability of biosynthesis products.
Affiliation:
Systems and Synthetic Biology Group, Helmholtz Centre for Infection Research, Inhoffenstraße 7, D-38124 Braunschweig, Germany; Systems and Synthetic Biology, Wageningen University, Dreijenplein 10, Building number 316, 6703 HB Wageningen, The Netherlands.
Citation:
Programmable bacterial catalysis - designing cells for biosynthesis of value-added compounds. 2012, 586 (15):2184-90 FEBS Lett.
Journal:
FEBS letters
Issue Date:
16-Jul-2012
URI:
http://hdl.handle.net/10033/244999
DOI:
10.1016/j.febslet.2012.02.030
PubMed ID:
22710181
Type:
Article
Language:
en
ISSN:
1873-3468
Appears in Collections:
Publications of Dept. Gene Regulation and Differentiation (RDIF)

Full metadata record

DC FieldValue Language
dc.contributor.authorLam, Carolyn M Cen_GB
dc.contributor.authorSuárez Diez, Maríaen_GB
dc.contributor.authorGodinho, Miguelen_GB
dc.contributor.authorMartins Dos Santos, Vítor A Pen_GB
dc.date.accessioned2012-09-19T13:37:40Z-
dc.date.available2012-09-19T13:37:40Z-
dc.date.issued2012-07-16-
dc.identifier.citationProgrammable bacterial catalysis - designing cells for biosynthesis of value-added compounds. 2012, 586 (15):2184-90 FEBS Lett.en_GB
dc.identifier.issn1873-3468-
dc.identifier.pmid22710181-
dc.identifier.doi10.1016/j.febslet.2012.02.030-
dc.identifier.urihttp://hdl.handle.net/10033/244999-
dc.description.abstractBacteria have long been used for the synthesis of a wide range of useful proteins and compounds. The developments of new bioprocesses and improvements of existing strategies for syntheses of valuable products in various bacterial cell hosts have their own challenges and limitations. The field of synthetic biology has combined knowledge from different science and engineering disciplines and facilitated the advancement of novel biological components which has inspired the design of targeted biosynthesis. Here we discuss recent advances in synthetic biology with relevance to biosynthesis in bacteria and the applications of computational algorithms and tools for manipulation of cellular components. Continuous improvements are necessary to keep up with increasing demands in terms of complexity, scale, and predictability of biosynthesis products.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to FEBS lettersen_GB
dc.titleProgrammable bacterial catalysis - designing cells for biosynthesis of value-added compounds.en
dc.typeArticleen
dc.contributor.departmentSystems and Synthetic Biology Group, Helmholtz Centre for Infection Research, Inhoffenstraße 7, D-38124 Braunschweig, Germany; Systems and Synthetic Biology, Wageningen University, Dreijenplein 10, Building number 316, 6703 HB Wageningen, The Netherlands.en_GB
dc.identifier.journalFEBS lettersen_GB

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