The Csr/Rsm system of Yersinia and related pathogens: A post-transcriptional strategy for managing virulence.

2.50
HDL Handle:
http://hdl.handle.net/10033/246492
Title:
The Csr/Rsm system of Yersinia and related pathogens: A post-transcriptional strategy for managing virulence.
Authors:
Heroven, Ann Kathrin; Böhme, Katja; Dersch, Petra
Abstract:
This review emphasizes the function and regulation of the Csr regulatory system in the human enteropathogen Yersinia pseudotuberculosis and compares its features with the homologous Csr/Rsm systems of related pathogens. The Csr/Rsm systems of eubacteria form a complex regulatory network in which redundant non-translated Csr/Rsm-RNAs bind the RNA-binding protein CsrA/RsmA, thereby preventing its interaction with mRNA targets. The Csr system is controlled by the BarA/UvrY-type of two-component sensor-regulator systems. Apart from that, common or pathogen-specific regulators control the abundance of the Csr components. The coordinate control of virulence factors and infection-linked physiological traits by the Csr/Rsm systems helps the pathogens to adapt individually to rapidly changing conditions to which they are exposed during the different stages of an infection. As Csr/Rsm function is relevant for full virulence, it represents a target suitable for antimicrobial drug development.
Affiliation:
Department of Molecular Infection Biology; Helmholtz Centre for Infection Research; Braunschweig, Germany; These authors contributed equally to this work.
Citation:
The Csr/Rsm system of Yersinia and related pathogens: A post-transcriptional strategy for managing virulence. 2012, 9 (4):notRNA Biol
Journal:
RNA biology
Issue Date:
1-Apr-2012
URI:
http://hdl.handle.net/10033/246492
PubMed ID:
22336760
Type:
Article
ISSN:
1555-8584
Appears in Collections:
Publications of Molekulare Infektionsbiologie(MIBI)

Full metadata record

DC FieldValueLanguage
dc.contributor.authorHeroven, Ann Kathrinen_GB
dc.contributor.authorBöhme, Katjaen_GB
dc.contributor.authorDersch, Petraen_GB
dc.date.accessioned2012-10-02T08:21:07Z-
dc.date.available2012-10-02T08:21:07Z-
dc.date.issued2012-04-01-
dc.identifier.citationThe Csr/Rsm system of Yersinia and related pathogens: A post-transcriptional strategy for managing virulence. 2012, 9 (4):notRNA Biolen_GB
dc.identifier.issn1555-8584-
dc.identifier.pmid22336760-
dc.identifier.urihttp://hdl.handle.net/10033/246492-
dc.description.abstractThis review emphasizes the function and regulation of the Csr regulatory system in the human enteropathogen Yersinia pseudotuberculosis and compares its features with the homologous Csr/Rsm systems of related pathogens. The Csr/Rsm systems of eubacteria form a complex regulatory network in which redundant non-translated Csr/Rsm-RNAs bind the RNA-binding protein CsrA/RsmA, thereby preventing its interaction with mRNA targets. The Csr system is controlled by the BarA/UvrY-type of two-component sensor-regulator systems. Apart from that, common or pathogen-specific regulators control the abundance of the Csr components. The coordinate control of virulence factors and infection-linked physiological traits by the Csr/Rsm systems helps the pathogens to adapt individually to rapidly changing conditions to which they are exposed during the different stages of an infection. As Csr/Rsm function is relevant for full virulence, it represents a target suitable for antimicrobial drug development.en_GB
dc.languageENG-
dc.rightsArchived with thanks to RNA biologyen_GB
dc.titleThe Csr/Rsm system of Yersinia and related pathogens: A post-transcriptional strategy for managing virulence.-
dc.typeArticleen
dc.contributor.departmentDepartment of Molecular Infection Biology; Helmholtz Centre for Infection Research; Braunschweig, Germany; These authors contributed equally to this work.en_GB
dc.identifier.journalRNA biologyen_GB
This item is licensed under a Creative Commons License
Creative Commons
All Items in HZI are protected by copyright, with all rights reserved, unless otherwise indicated.