|
|
Helmholtz Zentrum für Infektionsforschung Repository >
Division of Microbiology (MIK) >
Dept. Medizinische Mikrobiologie (MMIK) >
Publications of Dept. Medizinische Mikrobiologie (MMIK) >
A novel role for the transcription factor HIF-1α in the formation of mast cell extracellular traps.
Please use
this identifier to cite or link
to this item:
http://hdl.handle.net/10033/247551
 Del.icio.us
 LinkedIn
 Citeulike
 Connotea
 Facebook
 Stumble it!
| Title: | A novel role for the transcription factor HIF-1α in the formation of mast cell extracellular traps. |
| Authors: | Branitzki-Heinemann, Katja
Okumura, Cheryl Y
Völlger, Lena
Kawakami, Yuko
Kawakami, Toshiaki
Naim, Hassan Y
Nizet, Victor
Von Köckritz-Blickwede, Maren |
| Affiliation: | Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA. |
| Citation: | A novel role for the transcription factor HIF-1α in the formation of mast cell extracellular traps. 2012, 446 (1):159-63 Biochem. J. |
| Journal: | The Biochemical journal |
| Issue Date: | 15-Aug-2012 |
| URI: | http://hdl.handle.net/10033/247551 |
| DOI: | 10.1042/BJ20120658 |
| PubMed ID: | 22738198 |
| Abstract: | MCs (mast cells) are critical components of the host innate immune defence against bacterial pathogens, providing a variety of intra- and extra-cellular antimicrobial functions. In the present study we show, for the first time, that the transcriptional regulator HIF-1α (hypoxia-inducible factor-1α) mediates the extracellular antimicrobial activity of human and murine MCs by increasing the formation of MCETs (MC extracellular traps). |
| Type: | Article |
| Language: | en |
| ISSN: | 1470-8728 |
| Appears in Collections: | Publications of Dept. Medizinische Mikrobiologie (MMIK)
|
| Files in This Item: |
| File |
Description |
Size |
Format |
View/Open |
| Branitzki-Heinemann_2012_supplements.pdf | supplemental material | 146Kb | Adobe PDF | 
View/Open | | Branitzki-Heinemann et al_final.pdf | original manuscript | 333Kb | Adobe PDF | 
View/Open |
|
| Related articles on PubMed | | | |  | A new pharmacological agent (AKB-4924) stabilizes hypoxia inducible factor-1 (HIF-1) and increases skin innate defenses against bacterial infection.Okumura CY, Hollands A, Tran DN, Olson J, Dahesh S, von Köckritz-Blickwede M, Thienphrapa W, Corle C, Jeung SN, Kotsakis A, Shalwitz RA, Johnson RS, Nizet V 2012 Sep |
| | | See all 99 articles |
This item is licensed under a Creative Commons License
All Items in HZI are protected by copyright, with all rights reserved, unless otherwise indicated.
|
