2.50
Hdl Handle:
http://hdl.handle.net/10033/247551
Title:
A novel role for the transcription factor HIF-1α in the formation of mast cell extracellular traps.
Authors:
Branitzki-Heinemann, Katja; Okumura, Cheryl Y; Völlger, Lena; Kawakami, Yuko; Kawakami, Toshiaki; Naim, Hassan Y; Nizet, Victor; Von Köckritz-Blickwede, Maren
Abstract:
MCs (mast cells) are critical components of the host innate immune defence against bacterial pathogens, providing a variety of intra- and extra-cellular antimicrobial functions. In the present study we show, for the first time, that the transcriptional regulator HIF-1α (hypoxia-inducible factor-1α) mediates the extracellular antimicrobial activity of human and murine MCs by increasing the formation of MCETs (MC extracellular traps).
Affiliation:
Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA.
Citation:
A novel role for the transcription factor HIF-1α in the formation of mast cell extracellular traps. 2012, 446 (1):159-63 Biochem. J.
Journal:
The Biochemical journal
Issue Date:
15-Aug-2012
URI:
http://hdl.handle.net/10033/247551
DOI:
10.1042/BJ20120658
PubMed ID:
22738198
Type:
Article
Language:
en
ISSN:
1470-8728
Appears in Collections:
Publications of Dept. Medizinische Mikrobiologie (MMIK)

Full metadata record

DC FieldValue Language
dc.contributor.authorBranitzki-Heinemann, Katjaen_GB
dc.contributor.authorOkumura, Cheryl Yen_GB
dc.contributor.authorVöllger, Lenaen_GB
dc.contributor.authorKawakami, Yukoen_GB
dc.contributor.authorKawakami, Toshiakien_GB
dc.contributor.authorNaim, Hassan Yen_GB
dc.contributor.authorNizet, Victoren_GB
dc.contributor.authorVon Köckritz-Blickwede, Marenen_GB
dc.date.accessioned2012-10-08T12:37:28Z-
dc.date.available2012-10-08T12:37:28Z-
dc.date.issued2012-08-15-
dc.identifier.citationA novel role for the transcription factor HIF-1α in the formation of mast cell extracellular traps. 2012, 446 (1):159-63 Biochem. J.en_GB
dc.identifier.issn1470-8728-
dc.identifier.pmid22738198-
dc.identifier.doi10.1042/BJ20120658-
dc.identifier.urihttp://hdl.handle.net/10033/247551-
dc.description.abstractMCs (mast cells) are critical components of the host innate immune defence against bacterial pathogens, providing a variety of intra- and extra-cellular antimicrobial functions. In the present study we show, for the first time, that the transcriptional regulator HIF-1α (hypoxia-inducible factor-1α) mediates the extracellular antimicrobial activity of human and murine MCs by increasing the formation of MCETs (MC extracellular traps).en_GB
dc.language.isoenen
dc.rightsArchived with thanks to The Biochemical journalen_GB
dc.titleA novel role for the transcription factor HIF-1α in the formation of mast cell extracellular traps.en
dc.typeArticleen
dc.contributor.departmentDepartment of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA.en_GB
dc.identifier.journalThe Biochemical journalen_GB

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