2.50
HDL Handle:
http://hdl.handle.net/10033/24872
Title:
Cyclic depsipeptides, ichthyopeptins A and B, from Microcystis ichthyoblabe.
Authors:
Zainuddin, Elmi N; Mentel, Renate; Wray, Victor; Jansen, Rolf; Nimtz, Manfred; Lalk, Michael; Mundt, Sabine
Abstract:
Bioassay-guided isolation of antiviral compounds from the cultured cyanobacterium Microcystis ichthyoblabe provided two novel cyclic depsipeptides, ichthyopeptins A (1) and B (2). Their structures were determined by 1D (1H and 13C) and 2D (COSY, TOCSY, ROESY, HMQC, and HMBC) NMR spectra, ESIMS-MS, and amino acid analysis. The fraction containing both cyclic depsipeptides exhibited antiviral activity against influenza A virus with an IC50 value of 12.5 microg/mL.
Affiliation:
Institute of Pharmacy, Friedrich-Ludwig-Jahnstrasse 17, Ernst-Moritz-Arndt University, D-17487 Greifswald, Germany.
Citation:
Cyclic depsipeptides, ichthyopeptins A and B, from Microcystis ichthyoblabe. 2007, 70 (7):1084-8 J. Nat. Prod.
Journal:
Journal of natural products
Issue Date:
Jul-2007
URI:
http://hdl.handle.net/10033/24872
DOI:
10.1021/np060303s
PubMed ID:
17602586
Type:
Article
Language:
en
ISSN:
0163-3864
Appears in Collections:
Publications of RG Microbial Drugs (MWIS)

Full metadata record

DC FieldValueLanguage
dc.contributor.authorZainuddin, Elmi N-
dc.contributor.authorMentel, Renate-
dc.contributor.authorWray, Victor-
dc.contributor.authorJansen, Rolf-
dc.contributor.authorNimtz, Manfred-
dc.contributor.authorLalk, Michael-
dc.contributor.authorMundt, Sabine-
dc.date.accessioned2008-05-06T13:13:23Z-
dc.date.available2008-05-06T13:13:23Z-
dc.date.issued2007-07-
dc.identifier.citationCyclic depsipeptides, ichthyopeptins A and B, from Microcystis ichthyoblabe. 2007, 70 (7):1084-8 J. Nat. Prod.en
dc.identifier.issn0163-3864-
dc.identifier.pmid17602586-
dc.identifier.doi10.1021/np060303s-
dc.identifier.urihttp://hdl.handle.net/10033/24872-
dc.description.abstractBioassay-guided isolation of antiviral compounds from the cultured cyanobacterium Microcystis ichthyoblabe provided two novel cyclic depsipeptides, ichthyopeptins A (1) and B (2). Their structures were determined by 1D (1H and 13C) and 2D (COSY, TOCSY, ROESY, HMQC, and HMBC) NMR spectra, ESIMS-MS, and amino acid analysis. The fraction containing both cyclic depsipeptides exhibited antiviral activity against influenza A virus with an IC50 value of 12.5 microg/mL.en
dc.language.isoenen
dc.subject.meshAntiviral Agentsen
dc.subject.meshDepsipeptidesen
dc.subject.meshGermanyen
dc.subject.meshInfluenza A virusen
dc.subject.meshInhibitory Concentration 50en
dc.subject.meshMicrocystisen
dc.subject.meshMolecular Structureen
dc.subject.meshNuclear Magnetic Resonance, Biomolecularen
dc.titleCyclic depsipeptides, ichthyopeptins A and B, from Microcystis ichthyoblabe.en
dc.typeArticleen
dc.contributor.departmentInstitute of Pharmacy, Friedrich-Ludwig-Jahnstrasse 17, Ernst-Moritz-Arndt University, D-17487 Greifswald, Germany.en
dc.identifier.journalJournal of natural productsen

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