| Title: | Cyclic depsipeptides, ichthyopeptins A and B, from Microcystis ichthyoblabe. |
| Authors: | Zainuddin, Elmi N
Mentel, Renate
Wray, Victor
Jansen, Rolf
Nimtz, Manfred
Lalk, Michael
Mundt, Sabine |
| Affiliation: | Institute of Pharmacy, Friedrich-Ludwig-Jahnstrasse 17, Ernst-Moritz-Arndt University, D-17487 Greifswald, Germany. |
| Citation: | Cyclic depsipeptides, ichthyopeptins A and B, from Microcystis ichthyoblabe. 2007, 70 (7):1084-8 J. Nat. Prod. |
| Journal: | Journal of natural products |
| Issue Date: | Jul-2007 |
| URI: | http://hdl.handle.net/10033/24872 |
| DOI: | 10.1021/np060303s |
| PubMed ID: | 17602586 |
| Abstract: | Bioassay-guided isolation of antiviral compounds from the cultured cyanobacterium Microcystis ichthyoblabe provided two novel cyclic depsipeptides, ichthyopeptins A (1) and B (2). Their structures were determined by 1D (1H and 13C) and 2D (COSY, TOCSY, ROESY, HMQC, and HMBC) NMR spectra, ESIMS-MS, and amino acid analysis. The fraction containing both cyclic depsipeptides exhibited antiviral activity against influenza A virus with an IC50 value of 12.5 microg/mL. |
| Type: | Article |
| Language: | en |
| MeSH: | Antiviral Agents
Depsipeptides
Germany
Influenza A virus
Inhibitory Concentration 50
Microcystis
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular |
| ISSN: | 0163-3864 |
| Appears in Collections: | Publications of RG Microbial Drugs (MWIS)
|
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| Zainuddin_final.pdf | original manuscript | 224Kb | Adobe PDF | 
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