2.50
Hdl Handle:
http://hdl.handle.net/10033/254117
Title:
The pseudomonas quinolone signal (PQS) balances life and death in Pseudomonas aeruginosa populations.
Authors:
Häussler, Susanne; Becker, Tanja
Abstract:
When environmental conditions deteriorate and become inhospitable, generic survival strategies for populations of bacteria may be to enter a dormant state that slows down metabolism, to develop a general tolerance to hostile parameters that characterize the habitat, and to impose a regime to eliminate damaged members. Here, we provide evidence that the pseudomonas quinolone signal (PQS) mediates induction of all of these phenotypes. For individual cells, PQS, an interbacterial signaling molecule of Pseudomonas aeruginosa, has both deleterious and beneficial activities: on the one hand, it acts as a pro-oxidant and sensitizes the bacteria towards oxidative and other stresses and, on the other, it efficiently induces a protective anti-oxidative stress response. We propose that this dual function fragments populations into less and more stress tolerant members which respond differentially to developing stresses in deteriorating habitats. This suggests that a little poison may be generically beneficial to populations, in promoting survival of the fittest, and in contributing to bacterial multi-cellular behavior. It further identifies PQS as an essential mediator of the shaping of the population structure of Pseudomonas and of its response to and survival in hostile environmental conditions.
Affiliation:
Department of Cell Biology, Helmholtz Center for Infection Research, Braunschweig, Germany. susanne.haeussler@helmholtz-hzi.de
Citation:
The pseudomonas quinolone signal (PQS) balances life and death in Pseudomonas aeruginosa populations. 2008, 4 (9):e1000166 PLoS Pathog.
Journal:
PLoS pathogens
Issue Date:
2008
URI:
http://hdl.handle.net/10033/254117
DOI:
10.1371/journal.ppat.1000166
PubMed ID:
18818733
Type:
Article
Language:
en
ISSN:
1553-7374
Appears in Collections:
Publications of JRG Chronic Pseudomonas Diseases (CPI)

Full metadata record

DC FieldValue Language
dc.contributor.authorHäussler, Susanneen_GB
dc.contributor.authorBecker, Tanjaen_GB
dc.date.accessioned2012-11-30T16:48:04Z-
dc.date.available2012-11-30T16:48:04Z-
dc.date.issued2008-
dc.identifier.citationThe pseudomonas quinolone signal (PQS) balances life and death in Pseudomonas aeruginosa populations. 2008, 4 (9):e1000166 PLoS Pathog.en_GB
dc.identifier.issn1553-7374-
dc.identifier.pmid18818733-
dc.identifier.doi10.1371/journal.ppat.1000166-
dc.identifier.urihttp://hdl.handle.net/10033/254117-
dc.description.abstractWhen environmental conditions deteriorate and become inhospitable, generic survival strategies for populations of bacteria may be to enter a dormant state that slows down metabolism, to develop a general tolerance to hostile parameters that characterize the habitat, and to impose a regime to eliminate damaged members. Here, we provide evidence that the pseudomonas quinolone signal (PQS) mediates induction of all of these phenotypes. For individual cells, PQS, an interbacterial signaling molecule of Pseudomonas aeruginosa, has both deleterious and beneficial activities: on the one hand, it acts as a pro-oxidant and sensitizes the bacteria towards oxidative and other stresses and, on the other, it efficiently induces a protective anti-oxidative stress response. We propose that this dual function fragments populations into less and more stress tolerant members which respond differentially to developing stresses in deteriorating habitats. This suggests that a little poison may be generically beneficial to populations, in promoting survival of the fittest, and in contributing to bacterial multi-cellular behavior. It further identifies PQS as an essential mediator of the shaping of the population structure of Pseudomonas and of its response to and survival in hostile environmental conditions.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to PLoS pathogensen_GB
dc.subject.mesh4-Quinolonesen_GB
dc.subject.meshAntioxidantsen_GB
dc.subject.meshOxidantsen_GB
dc.subject.meshPseudomonas aeruginosaen_GB
dc.subject.meshQuinolonesen_GB
dc.subject.meshQuorum Sensingen_GB
dc.subject.meshReactive Oxygen Speciesen_GB
dc.subject.meshSelection, Geneticen_GB
dc.titleThe pseudomonas quinolone signal (PQS) balances life and death in Pseudomonas aeruginosa populations.en
dc.typeArticleen
dc.contributor.departmentDepartment of Cell Biology, Helmholtz Center for Infection Research, Braunschweig, Germany. susanne.haeussler@helmholtz-hzi.deen_GB
dc.identifier.journalPLoS pathogensen_GB

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