Absence of Foxp3(+) Regulatory T Cells during Allergen Provocation Does Not Exacerbate Murine Allergic Airway Inflammation.

2.50
Hdl Handle:
http://hdl.handle.net/10033/254152
Title:
Absence of Foxp3(+) Regulatory T Cells during Allergen Provocation Does Not Exacerbate Murine Allergic Airway Inflammation.
Authors:
Baru, Abdul Mannan; Ganesh, Venkateswaran; Krishnaswamy, Jayendra Kumar; Hesse, Christina; Untucht, Christopher; Glage, Silke; Behrens, Georg; Mayer, Christian Thomas; Puttur, Franz; Sparwasser, Tim
Abstract:
Regulatory T cells (Tregs) play a non-redundant role in maintenance of immune homeostasis. This is achieved by suppressing both, priming of naïve cells and effector cell functions. Although Tregs have been implicated in modulating allergic immune responses, their influence on distinct phases of development of allergies remains unclear. In this study, by using bacterial artificial chromosome (BAC)-transgenic Foxp3-DTR (DEREG) mice we demonstrate that the absence of Foxp3(+) Tregs during the allergen challenge surprisingly does not exacerbate allergic airway inflammation in BALB/c mice. As genetic disposition due to strain specificity may contribute significantly to development of allergies, we performed similar experiment in C57BL/6 mice, which are less susceptible to allergy in the model of sensitization used in this study. We report that the genetic background does not influence the consequence of this depletion regimen. These results signify the temporal regulation exerted by Foxp3(+) Tregs in limiting allergic airway inflammation and may influence their application as potential therapeutics.
Affiliation:
Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany.
Citation:
Absence of Foxp3(+) Regulatory T Cells during Allergen Provocation Does Not Exacerbate Murine Allergic Airway Inflammation. 2012, 7 (10):e47102 PLoS ONE
Journal:
PloS one
Issue Date:
2012
URI:
http://hdl.handle.net/10033/254152
DOI:
10.1371/journal.pone.0047102
PubMed ID:
23071726
Type:
Article
Language:
en
ISSN:
1932-6203
Appears in Collections:
publications of the TwinCore unit Infection immunology

Full metadata record

DC FieldValue Language
dc.contributor.authorBaru, Abdul Mannanen_GB
dc.contributor.authorGanesh, Venkateswaranen_GB
dc.contributor.authorKrishnaswamy, Jayendra Kumaren_GB
dc.contributor.authorHesse, Christinaen_GB
dc.contributor.authorUntucht, Christopheren_GB
dc.contributor.authorGlage, Silkeen_GB
dc.contributor.authorBehrens, Georgen_GB
dc.contributor.authorMayer, Christian Thomasen_GB
dc.contributor.authorPuttur, Franzen_GB
dc.contributor.authorSparwasser, Timen_GB
dc.date.accessioned2012-11-30T17:13:22Z-
dc.date.available2012-11-30T17:13:22Z-
dc.date.issued2012-
dc.identifier.citationAbsence of Foxp3(+) Regulatory T Cells during Allergen Provocation Does Not Exacerbate Murine Allergic Airway Inflammation. 2012, 7 (10):e47102 PLoS ONEen_GB
dc.identifier.issn1932-6203-
dc.identifier.pmid23071726-
dc.identifier.doi10.1371/journal.pone.0047102-
dc.identifier.urihttp://hdl.handle.net/10033/254152-
dc.description.abstractRegulatory T cells (Tregs) play a non-redundant role in maintenance of immune homeostasis. This is achieved by suppressing both, priming of naïve cells and effector cell functions. Although Tregs have been implicated in modulating allergic immune responses, their influence on distinct phases of development of allergies remains unclear. In this study, by using bacterial artificial chromosome (BAC)-transgenic Foxp3-DTR (DEREG) mice we demonstrate that the absence of Foxp3(+) Tregs during the allergen challenge surprisingly does not exacerbate allergic airway inflammation in BALB/c mice. As genetic disposition due to strain specificity may contribute significantly to development of allergies, we performed similar experiment in C57BL/6 mice, which are less susceptible to allergy in the model of sensitization used in this study. We report that the genetic background does not influence the consequence of this depletion regimen. These results signify the temporal regulation exerted by Foxp3(+) Tregs in limiting allergic airway inflammation and may influence their application as potential therapeutics.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to PloS oneen_GB
dc.titleAbsence of Foxp3(+) Regulatory T Cells during Allergen Provocation Does Not Exacerbate Murine Allergic Airway Inflammation.en
dc.typeArticleen
dc.contributor.departmentInstitute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany.en_GB
dc.identifier.journalPloS oneen_GB

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