Regulatory T cells increase the avidity of primary CD8+ T cell responses and promote memory.

2.50
Hdl Handle:
http://hdl.handle.net/10033/256493
Title:
Regulatory T cells increase the avidity of primary CD8+ T cell responses and promote memory.
Authors:
Pace, Luigia; Tempez, Andy; Arnold-Schrauf, Catharina; Lemaitre, Fabrice; Bousso, Philippe; Fetler, Luc; Sparwasser, Tim; Amigorena, Sebastian
Abstract:
Although regulatory T cells (T(regs)) are known to suppress self-reactive autoimmune responses, their role during T cell responses to nonself antigens is not well understood. We show that T(regs) play a critical role during the priming of immune responses in mice. T(reg) depletion induced the activation and expansion of a population of low-avidity CD8(+) T cells because of overproduction of CCL-3/4/5 chemokines, which stabilized the interactions between antigen-presenting dendritic cells and low-avidity T cells. In the absence of T(regs), the avidity of the primary immune response was impaired, which resulted in reduced memory to Listeria monocytogenes. These results suggest that T(regs) are important regulators of the homeostasis of CD8(+) T cell priming and play a critical role in the induction of high-avidity primary responses and effective memory.
Affiliation:
INSERM U932, Immunity and Cancer, Institut Curie, F-75248 Paris Cedex 05, France.
Citation:
Regulatory T cells increase the avidity of primary CD8+ T cell responses and promote memory. 2012, 338 (6106):532-6 Science
Journal:
Science (New York, N.Y.)
Issue Date:
26-Oct-2012
URI:
http://hdl.handle.net/10033/256493
DOI:
10.1126/science.1227049
PubMed ID:
23112334
Type:
Article
Language:
en
ISSN:
1095-9203
Appears in Collections:
publications of the TwinCore unit Infection immunology

Full metadata record

DC FieldValue Language
dc.contributor.authorPace, Luigiaen_GB
dc.contributor.authorTempez, Andyen_GB
dc.contributor.authorArnold-Schrauf, Catharinaen_GB
dc.contributor.authorLemaitre, Fabriceen_GB
dc.contributor.authorBousso, Philippeen_GB
dc.contributor.authorFetler, Lucen_GB
dc.contributor.authorSparwasser, Timen_GB
dc.contributor.authorAmigorena, Sebastianen_GB
dc.date.accessioned2012-12-12T14:07:20Z-
dc.date.available2012-12-12T14:07:20Z-
dc.date.issued2012-10-26-
dc.identifier.citationRegulatory T cells increase the avidity of primary CD8+ T cell responses and promote memory. 2012, 338 (6106):532-6 Scienceen_GB
dc.identifier.issn1095-9203-
dc.identifier.pmid23112334-
dc.identifier.doi10.1126/science.1227049-
dc.identifier.urihttp://hdl.handle.net/10033/256493-
dc.description.abstractAlthough regulatory T cells (T(regs)) are known to suppress self-reactive autoimmune responses, their role during T cell responses to nonself antigens is not well understood. We show that T(regs) play a critical role during the priming of immune responses in mice. T(reg) depletion induced the activation and expansion of a population of low-avidity CD8(+) T cells because of overproduction of CCL-3/4/5 chemokines, which stabilized the interactions between antigen-presenting dendritic cells and low-avidity T cells. In the absence of T(regs), the avidity of the primary immune response was impaired, which resulted in reduced memory to Listeria monocytogenes. These results suggest that T(regs) are important regulators of the homeostasis of CD8(+) T cell priming and play a critical role in the induction of high-avidity primary responses and effective memory.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Science (New York, N.Y.)en_GB
dc.subject.meshAnimalsen_GB
dc.subject.meshCD8-Positive T-Lymphocytesen_GB
dc.subject.meshChemokine CCL1en_GB
dc.subject.meshChemokine CCL4en_GB
dc.subject.meshChemokine CCL5en_GB
dc.subject.meshFemaleen_GB
dc.subject.meshImmunity, Cellularen_GB
dc.subject.meshImmunologic Memoryen_GB
dc.subject.meshListeria monocytogenesen_GB
dc.subject.meshListeriosisen_GB
dc.subject.meshLymphocyte Depletionen_GB
dc.subject.meshMiceen_GB
dc.subject.meshMice, Inbred C57BLen_GB
dc.subject.meshProteinsen_GB
dc.subject.meshT-Lymphocytes, Regulatoryen_GB
dc.titleRegulatory T cells increase the avidity of primary CD8+ T cell responses and promote memory.en
dc.typeArticleen
dc.contributor.departmentINSERM U932, Immunity and Cancer, Institut Curie, F-75248 Paris Cedex 05, France.en_GB
dc.identifier.journalScience (New York, N.Y.)en_GB

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