Differential responses of immune cells to type I interferon contribute to host resistance to viral infection.

2.50
Hdl Handle:
http://hdl.handle.net/10033/262673
Title:
Differential responses of immune cells to type I interferon contribute to host resistance to viral infection.
Authors:
Baranek, Thomas; Manh, Thien-Phong Vu; Alexandre, Yannick; Maqbool, Muhammad Ahmad; Cabeza, Joaquin Zacarias; Tomasello, Elena; Crozat, Karine; Bessou, Gilles; Zucchini, Nicolas; Robbins, Scott H; Vivier, Eric; Kalinke, Ulrich ( 0000-0003-0503-9564 ) ; Ferrier, Pierre; Dalod, Marc
Abstract:
Type I interferons (IFNs) are central to antiviral defense, but how they orchestrate immune cell function is incompletely understood. We determined that IFNs produced during murine cytomegalovirus (MCMV) infection differentially affect dendritic cells (DCs) and natural killer (NK) cells. IFNs induce cell-intrinsic responses in DCs, activating antiproliferative, antiviral, and lymphocyte-activating gene networks, consistent with high activity of the transcription factor STAT1 in these cells. By comparison, NK cells exhibit lower STAT1 expression and reduced IFN responsiveness. Rather, IFNs indirectly affect NK cells by inducing IL-15, which activates the transcription factor E2F and stimulates genes promoting cell expansion. IFN cell-intrinsic responses are necessary in DCs, but not NK cells, for MCMV resistance. Thus, sensitivity to IFN-induced cytokines and differences in IFN receptor signaling program immune cells to mount distinct responses that promote viral control.
Affiliation:
Centre d'Immunologie de Marseille-Luminy, UNIV UM2, Aix-Marseille Université, Parc scientifique et technologique de Luminy, 13288 Marseille, France; Institut National de la Santé et de la Recherche Medicale (Inserm), UMR1104, 13288 Marseille, France; Centre National de la Recherche Scientifique (CNRS), UMR7280, 13288 Marseille, France.
Citation:
Differential responses of immune cells to type I interferon contribute to host resistance to viral infection. 2012, 12 (4):571-84 Cell Host Microbe
Journal:
Cell host & microbe
Issue Date:
18-Oct-2012
URI:
http://hdl.handle.net/10033/262673
DOI:
10.1016/j.chom.2012.09.002
PubMed ID:
23084923
Type:
Article
Language:
en
ISSN:
1934-6069
Appears in Collections:
Publications of the TwinCore unit experimental Infectionresearch(EXPI)

Full metadata record

DC FieldValue Language
dc.contributor.authorBaranek, Thomasen_GB
dc.contributor.authorManh, Thien-Phong Vuen_GB
dc.contributor.authorAlexandre, Yannicken_GB
dc.contributor.authorMaqbool, Muhammad Ahmaden_GB
dc.contributor.authorCabeza, Joaquin Zacariasen_GB
dc.contributor.authorTomasello, Elenaen_GB
dc.contributor.authorCrozat, Karineen_GB
dc.contributor.authorBessou, Gillesen_GB
dc.contributor.authorZucchini, Nicolasen_GB
dc.contributor.authorRobbins, Scott Hen_GB
dc.contributor.authorVivier, Ericen_GB
dc.contributor.authorKalinke, Ulrichen_GB
dc.contributor.authorFerrier, Pierreen_GB
dc.contributor.authorDalod, Marcen_GB
dc.date.accessioned2012-12-14T11:55:13Zen
dc.date.available2012-12-14T11:55:13Zen
dc.date.issued2012-10-18en
dc.identifier.citationDifferential responses of immune cells to type I interferon contribute to host resistance to viral infection. 2012, 12 (4):571-84 Cell Host Microbeen_GB
dc.identifier.issn1934-6069en
dc.identifier.pmid23084923en
dc.identifier.doi10.1016/j.chom.2012.09.002en
dc.identifier.urihttp://hdl.handle.net/10033/262673en
dc.description.abstractType I interferons (IFNs) are central to antiviral defense, but how they orchestrate immune cell function is incompletely understood. We determined that IFNs produced during murine cytomegalovirus (MCMV) infection differentially affect dendritic cells (DCs) and natural killer (NK) cells. IFNs induce cell-intrinsic responses in DCs, activating antiproliferative, antiviral, and lymphocyte-activating gene networks, consistent with high activity of the transcription factor STAT1 in these cells. By comparison, NK cells exhibit lower STAT1 expression and reduced IFN responsiveness. Rather, IFNs indirectly affect NK cells by inducing IL-15, which activates the transcription factor E2F and stimulates genes promoting cell expansion. IFN cell-intrinsic responses are necessary in DCs, but not NK cells, for MCMV resistance. Thus, sensitivity to IFN-induced cytokines and differences in IFN receptor signaling program immune cells to mount distinct responses that promote viral control.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Cell host & microbeen_GB
dc.titleDifferential responses of immune cells to type I interferon contribute to host resistance to viral infection.en
dc.typeArticleen
dc.contributor.departmentCentre d'Immunologie de Marseille-Luminy, UNIV UM2, Aix-Marseille Université, Parc scientifique et technologique de Luminy, 13288 Marseille, France; Institut National de la Santé et de la Recherche Medicale (Inserm), UMR1104, 13288 Marseille, France; Centre National de la Recherche Scientifique (CNRS), UMR7280, 13288 Marseille, France.en_GB
dc.identifier.journalCell host & microbeen_GB

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