Hypoxylon pulicicidum sp. nov. (Ascomycota, Xylariales), a pantropical insecticide-producing endophyte.

2.50
Hdl Handle:
http://hdl.handle.net/10033/265912
Title:
Hypoxylon pulicicidum sp. nov. (Ascomycota, Xylariales), a pantropical insecticide-producing endophyte.
Authors:
Bills, Gerald F; González-Menéndez, Victor; Martín, Jesús; Platas, Gonzalo; Fournier, Jacques; Peršoh, Derek; Stadler, Marc ( 0000-0002-7284-8671 )
Abstract:
Nodulisporic acids (NAs) are indole diterpene fungal metabolites exhibiting potent systemic efficacy against blood-feeding arthropods, e.g., bedbugs, fleas and ticks, via binding to arthropod specific glutamate-gated chloride channels. Intensive medicinal chemistry efforts employing a nodulisporic acid A template have led to the development of N-tert-butyl nodulisporamide as a product candidate for a once monthly treatment of fleas and ticks on companion animals. The source of the NAs is a monophyletic lineage of asexual endophytic fungal strains that is widely distributed in the tropics, tentatively identified as a Nodulisporium species and hypothesized to be the asexual state of a Hypoxylon species.
Affiliation:
Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Parque Tecnológico de Ciencias de la Salud, Armilla, Granada, Spain. gerald.bills@medinaandalucia.es
Citation:
Hypoxylon pulicicidum sp. nov. (Ascomycota, Xylariales), a pantropical insecticide-producing endophyte. 2012, 7 (10):e46687 PLoS ONE
Journal:
PloS one
Issue Date:
2012
URI:
http://hdl.handle.net/10033/265912
DOI:
10.1371/journal.pone.0046687
PubMed ID:
23056404
Type:
Article
Language:
en
ISSN:
1932-6203
Appears in Collections:
Publications of the department Microbial Drugs (MWIS)

Full metadata record

DC FieldValue Language
dc.contributor.authorBills, Gerald Fen_GB
dc.contributor.authorGonzález-Menéndez, Victoren_GB
dc.contributor.authorMartín, Jesúsen_GB
dc.contributor.authorPlatas, Gonzaloen_GB
dc.contributor.authorFournier, Jacquesen_GB
dc.contributor.authorPeršoh, Dereken_GB
dc.contributor.authorStadler, Marcen_GB
dc.date.accessioned2013-01-17T15:22:27Zen
dc.date.available2013-01-17T15:22:27Zen
dc.date.issued2012en
dc.identifier.citationHypoxylon pulicicidum sp. nov. (Ascomycota, Xylariales), a pantropical insecticide-producing endophyte. 2012, 7 (10):e46687 PLoS ONEen_GB
dc.identifier.issn1932-6203en
dc.identifier.pmid23056404en
dc.identifier.doi10.1371/journal.pone.0046687en
dc.identifier.urihttp://hdl.handle.net/10033/265912en
dc.description.abstractNodulisporic acids (NAs) are indole diterpene fungal metabolites exhibiting potent systemic efficacy against blood-feeding arthropods, e.g., bedbugs, fleas and ticks, via binding to arthropod specific glutamate-gated chloride channels. Intensive medicinal chemistry efforts employing a nodulisporic acid A template have led to the development of N-tert-butyl nodulisporamide as a product candidate for a once monthly treatment of fleas and ticks on companion animals. The source of the NAs is a monophyletic lineage of asexual endophytic fungal strains that is widely distributed in the tropics, tentatively identified as a Nodulisporium species and hypothesized to be the asexual state of a Hypoxylon species.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to PloS oneen_GB
dc.titleHypoxylon pulicicidum sp. nov. (Ascomycota, Xylariales), a pantropical insecticide-producing endophyte.en
dc.typeArticleen
dc.contributor.departmentFundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Parque Tecnológico de Ciencias de la Salud, Armilla, Granada, Spain. gerald.bills@medinaandalucia.esen_GB
dc.identifier.journalPloS oneen_GB

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