2.50
Hdl Handle:
http://hdl.handle.net/10033/267332
Title:
Histological and molecular evaluation of iron as degradable medical implant material in a murine animal model.
Authors:
Mueller, Peter P; Arnold, Sylvia; Badar, Muhammad; Bormann, Dirk; Bach, Friedrich-Wilhelm; Drynda, Andreas; Meyer-Lindenberg, Andrea; Hauser, Hansjörg; Peuster, Matthias
Abstract:
A small animal model was established to evaluate the potential of iron as a degradable implant material. After insertion into the tail of mice, the implants gradually degraded over a clinically relevant time period of several months. Histological analysis and gene expression data from whole-genome microarray analyses indicated a limited inflammatory reaction. No evidence of cellular responses to excess iron ions was detected, suggesting that the iron degradation products were metabolically inactive. Iron-rich compounds could be detected in the vicinity of the implant and in individual cells distant from the implantation site. These results demonstrate that the mouse model could be useful for the primary in vivo evaluation of novel implant materials and that iron degradation products can accumulate in diverse organs of the body.
Affiliation:
Helmholtz Centre for Infection Research, Braunschweig, Germany. pmu@gbf.de
Citation:
Histological and molecular evaluation of iron as degradable medical implant material in a murine animal model. 2012, 100 (11):2881-9 J Biomed Mater Res A
Journal:
Journal of biomedical materials research. Part A
Issue Date:
Nov-2012
URI:
http://hdl.handle.net/10033/267332
DOI:
10.1002/jbm.a.34223
PubMed ID:
22623368
Type:
Article
Language:
en
ISSN:
1552-4965
Appears in Collections:
Publications of Dept. Gene Regulation and Differentiation (RDIF)

Full metadata record

DC FieldValue Language
dc.contributor.authorMueller, Peter Pen_GB
dc.contributor.authorArnold, Sylviaen_GB
dc.contributor.authorBadar, Muhammaden_GB
dc.contributor.authorBormann, Dirken_GB
dc.contributor.authorBach, Friedrich-Wilhelmen_GB
dc.contributor.authorDrynda, Andreasen_GB
dc.contributor.authorMeyer-Lindenberg, Andreaen_GB
dc.contributor.authorHauser, Hansjörgen_GB
dc.contributor.authorPeuster, Matthiasen_GB
dc.date.accessioned2013-01-28T15:17:07Z-
dc.date.available2013-01-28T15:17:07Z-
dc.date.issued2012-11-
dc.identifier.citationHistological and molecular evaluation of iron as degradable medical implant material in a murine animal model. 2012, 100 (11):2881-9 J Biomed Mater Res Aen_GB
dc.identifier.issn1552-4965-
dc.identifier.pmid22623368-
dc.identifier.doi10.1002/jbm.a.34223-
dc.identifier.urihttp://hdl.handle.net/10033/267332-
dc.description.abstractA small animal model was established to evaluate the potential of iron as a degradable implant material. After insertion into the tail of mice, the implants gradually degraded over a clinically relevant time period of several months. Histological analysis and gene expression data from whole-genome microarray analyses indicated a limited inflammatory reaction. No evidence of cellular responses to excess iron ions was detected, suggesting that the iron degradation products were metabolically inactive. Iron-rich compounds could be detected in the vicinity of the implant and in individual cells distant from the implantation site. These results demonstrate that the mouse model could be useful for the primary in vivo evaluation of novel implant materials and that iron degradation products can accumulate in diverse organs of the body.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Journal of biomedical materials research. Part Aen_GB
dc.titleHistological and molecular evaluation of iron as degradable medical implant material in a murine animal model.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for Infection Research, Braunschweig, Germany. pmu@gbf.deen_GB
dc.identifier.journalJournal of biomedical materials research. Part Aen_GB

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