Efficacy of nanoporous silica coatings on middle ear prostheses as a delivery system for antibiotics: an animal study in rabbits.

2.50
Hdl Handle:
http://hdl.handle.net/10033/269313
Title:
Efficacy of nanoporous silica coatings on middle ear prostheses as a delivery system for antibiotics: an animal study in rabbits.
Authors:
Lensing, Rebecca; Bleich, André; Smoczek, Anna; Glage, Silke; Ehlert, Nina; Luessenhop, Tammo; Behrens, Peter; Müller, Peter Paul; Kietzmann, Manfred; Stieve, Martin
Abstract:
Nanoporous silica layers are able to host molecules and release them over a certain period of time. These local drug delivery systems for antibiotics could be a new approach in the treatment of chronic otitis media. The aim of this study was to examine the efficacy of nanoporous silica coatings on middle ear prostheses as a delivery system for antibiotics in vivo. Pseudomonas aeruginosa was inoculated into the middle ear of rabbits to induce an otitis media. The control group received coated Bioverit®II implants without antibiotics. Coated prostheses with loaded ciprofloxacin were implanted into the middle ears of the study group. After 1 week, the rabbits were sacrificed. The clinical examination as well as the microbiological and histological examinations of organs and middle ear irrigation revealed clear differences between the two groups. P. aeruginosa was detected in every middle ear of the control group and was almost completely eliminated in the study group. Organ examinations revealed the presence of P. aeruginosa in the control group and a prevention of a bacterial spread in the study group. The nanoporous silica layer as antibiotic delivery system showed convincing efficacy in induced pseudomonal otitis media in the rabbit.
Affiliation:
Department of Otolaryngology, Hannover Medical School, Hannover, Germany. Lensing.Rebecca@mh-hannover.de
Citation:
Efficacy of nanoporous silica coatings on middle ear prostheses as a delivery system for antibiotics: an animal study in rabbits. 2013, 9 (1):4815-25 Acta Biomater
Journal:
Acta biomaterialia
Issue Date:
Jan-2013
URI:
http://hdl.handle.net/10033/269313
DOI:
10.1016/j.actbio.2012.08.016
PubMed ID:
22906623
Type:
Article
Language:
en
ISSN:
1878-7568
Appears in Collections:
Publications of Dept. Gene Regulation and Differentiation (RDIF)

Full metadata record

DC FieldValue Language
dc.contributor.authorLensing, Rebeccaen_GB
dc.contributor.authorBleich, Andréen_GB
dc.contributor.authorSmoczek, Annaen_GB
dc.contributor.authorGlage, Silkeen_GB
dc.contributor.authorEhlert, Ninaen_GB
dc.contributor.authorLuessenhop, Tammoen_GB
dc.contributor.authorBehrens, Peteren_GB
dc.contributor.authorMüller, Peter Paulen_GB
dc.contributor.authorKietzmann, Manfreden_GB
dc.contributor.authorStieve, Martinen_GB
dc.date.accessioned2013-02-13T10:17:45Z-
dc.date.available2013-02-13T10:17:45Z-
dc.date.issued2013-01-
dc.identifier.citationEfficacy of nanoporous silica coatings on middle ear prostheses as a delivery system for antibiotics: an animal study in rabbits. 2013, 9 (1):4815-25 Acta Biomateren_GB
dc.identifier.issn1878-7568-
dc.identifier.pmid22906623-
dc.identifier.doi10.1016/j.actbio.2012.08.016-
dc.identifier.urihttp://hdl.handle.net/10033/269313-
dc.description.abstractNanoporous silica layers are able to host molecules and release them over a certain period of time. These local drug delivery systems for antibiotics could be a new approach in the treatment of chronic otitis media. The aim of this study was to examine the efficacy of nanoporous silica coatings on middle ear prostheses as a delivery system for antibiotics in vivo. Pseudomonas aeruginosa was inoculated into the middle ear of rabbits to induce an otitis media. The control group received coated Bioverit®II implants without antibiotics. Coated prostheses with loaded ciprofloxacin were implanted into the middle ears of the study group. After 1 week, the rabbits were sacrificed. The clinical examination as well as the microbiological and histological examinations of organs and middle ear irrigation revealed clear differences between the two groups. P. aeruginosa was detected in every middle ear of the control group and was almost completely eliminated in the study group. Organ examinations revealed the presence of P. aeruginosa in the control group and a prevention of a bacterial spread in the study group. The nanoporous silica layer as antibiotic delivery system showed convincing efficacy in induced pseudomonal otitis media in the rabbit.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Acta biomaterialiaen_GB
dc.titleEfficacy of nanoporous silica coatings on middle ear prostheses as a delivery system for antibiotics: an animal study in rabbits.en
dc.typeArticleen
dc.contributor.departmentDepartment of Otolaryngology, Hannover Medical School, Hannover, Germany. Lensing.Rebecca@mh-hannover.deen_GB
dc.identifier.journalActa biomaterialiaen_GB

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