Mutations that alter use of hepatitis C virus cell entry factors mediate escape from neutralizing antibodies.

2.50
Hdl Handle:
http://hdl.handle.net/10033/270312
Title:
Mutations that alter use of hepatitis C virus cell entry factors mediate escape from neutralizing antibodies.
Authors:
Fofana, Isabel; Fafi-Kremer, Samira; Carolla, Patric; Fauvelle, Catherine; Zahid, Muhammad Nauman; Turek, Marine; Heydmann, Laura; Cury, Karine; Hayer, Juliette; Combet, Christophe; Cosset, François-Loïc; Pietschmann, Thomas; Hiet, Marie-Sophie; Bartenschlager, Ralf; Habersetzer, François; Doffoël, Michel; Keck, Zhen-Yong; Foung, Steven K H; Zeisel, Mirjam B; Stoll-Keller, Françoise; Baumert, Thomas F
Abstract:
The development of vaccines and other strategies to prevent hepatitis C virus (HCV) infection is limited by rapid viral evasion. HCV entry is the first step of infection; this process involves several viral and host factors and is targeted by host-neutralizing responses. Although the roles of host factors in HCV entry have been well characterized, their involvement in evasion of immune responses is poorly understood. We used acute infection of liver graft as a model to investigate the molecular mechanisms of viral evasion.
Affiliation:
Inserm, U748, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
Citation:
Mutations that alter use of hepatitis C virus cell entry factors mediate escape from neutralizing antibodies. 2012, 143 (1):223-233.e9 Gastroenterology
Journal:
Gastroenterology
Issue Date:
Jul-2012
URI:
http://hdl.handle.net/10033/270312
DOI:
10.1053/j.gastro.2012.04.006
PubMed ID:
22503792
Type:
Article
Language:
en
ISSN:
1528-0012
Appears in Collections:
publications of the department experimental Virology([TC]EVIR)

Full metadata record

DC FieldValue Language
dc.contributor.authorFofana, Isabelen_GB
dc.contributor.authorFafi-Kremer, Samiraen_GB
dc.contributor.authorCarolla, Patricen_GB
dc.contributor.authorFauvelle, Catherineen_GB
dc.contributor.authorZahid, Muhammad Naumanen_GB
dc.contributor.authorTurek, Marineen_GB
dc.contributor.authorHeydmann, Lauraen_GB
dc.contributor.authorCury, Karineen_GB
dc.contributor.authorHayer, Julietteen_GB
dc.contributor.authorCombet, Christopheen_GB
dc.contributor.authorCosset, François-Loïcen_GB
dc.contributor.authorPietschmann, Thomasen_GB
dc.contributor.authorHiet, Marie-Sophieen_GB
dc.contributor.authorBartenschlager, Ralfen_GB
dc.contributor.authorHabersetzer, Françoisen_GB
dc.contributor.authorDoffoël, Michelen_GB
dc.contributor.authorKeck, Zhen-Yongen_GB
dc.contributor.authorFoung, Steven K Hen_GB
dc.contributor.authorZeisel, Mirjam Ben_GB
dc.contributor.authorStoll-Keller, Françoiseen_GB
dc.contributor.authorBaumert, Thomas Fen_GB
dc.date.accessioned2013-02-25T10:38:41Z-
dc.date.available2013-02-25T10:38:41Z-
dc.date.issued2012-07-
dc.identifier.citationMutations that alter use of hepatitis C virus cell entry factors mediate escape from neutralizing antibodies. 2012, 143 (1):223-233.e9 Gastroenterologyen_GB
dc.identifier.issn1528-0012-
dc.identifier.pmid22503792-
dc.identifier.doi10.1053/j.gastro.2012.04.006-
dc.identifier.urihttp://hdl.handle.net/10033/270312-
dc.description.abstractThe development of vaccines and other strategies to prevent hepatitis C virus (HCV) infection is limited by rapid viral evasion. HCV entry is the first step of infection; this process involves several viral and host factors and is targeted by host-neutralizing responses. Although the roles of host factors in HCV entry have been well characterized, their involvement in evasion of immune responses is poorly understood. We used acute infection of liver graft as a model to investigate the molecular mechanisms of viral evasion.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Gastroenterologyen_GB
dc.subject.meshAntibodies, Neutralizingen_GB
dc.subject.meshCell Line, Tumoren_GB
dc.subject.meshHepacivirusen_GB
dc.subject.meshHepatitis Cen_GB
dc.subject.meshHumansen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMutationen_GB
dc.subject.meshTransplantsen_GB
dc.subject.meshVirus Internalizationen_GB
dc.titleMutations that alter use of hepatitis C virus cell entry factors mediate escape from neutralizing antibodies.en
dc.typeArticleen
dc.contributor.departmentInserm, U748, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.en_GB
dc.identifier.journalGastroenterologyen_GB

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