Distinct gene loci control the host response to influenza H1N1 virus infection in a time-dependent manner.

2.50
Hdl Handle:
http://hdl.handle.net/10033/278939
Title:
Distinct gene loci control the host response to influenza H1N1 virus infection in a time-dependent manner.
Authors:
Nedelko, Tatiana; Kollmus, Heike; Klawonn, Frank; Spijker, Sabine; Lu, Lu; Heßman, Manuela; Alberts, Rudi; Williams, Robert W; Schughart, Klaus ( 0000-0002-6824-7523 )
Abstract:
There is strong but mostly circumstantial evidence that genetic factors modulate the severity of influenza infection in humans. Using genetically diverse but fully inbred strains of mice it has been shown that host sequence variants have a strong influence on the severity of influenza A disease progression. In particular, C57BL/6J, the most widely used mouse strain in biomedical research, is comparatively resistant. In contrast, DBA/2J is highly susceptible.
Affiliation:
Department of Infection Genetics, Helmholtz Centre for Infection Research and University of Veterinary Medicine Hannover, 38124, Braunschweig, Germany.
Citation:
Distinct gene loci control the host response to influenza H1N1 virus infection in a time-dependent manner. 2012, 13:411 BMC Genomics
Journal:
BMC genomics
Issue Date:
2012
URI:
http://hdl.handle.net/10033/278939
DOI:
10.1186/1471-2164-13-411
PubMed ID:
22905720
Type:
Article
Language:
en
ISSN:
1471-2164
Appears in Collections:
publications of the department infection genetics (INFG)

Full metadata record

DC FieldValue Language
dc.contributor.authorNedelko, Tatianaen_GB
dc.contributor.authorKollmus, Heikeen_GB
dc.contributor.authorKlawonn, Franken_GB
dc.contributor.authorSpijker, Sabineen_GB
dc.contributor.authorLu, Luen_GB
dc.contributor.authorHeßman, Manuelaen_GB
dc.contributor.authorAlberts, Rudien_GB
dc.contributor.authorWilliams, Robert Wen_GB
dc.contributor.authorSchughart, Klausen_GB
dc.date.accessioned2013-04-04T13:30:16Zen
dc.date.available2013-04-04T13:30:16Zen
dc.date.issued2012en
dc.identifier.citationDistinct gene loci control the host response to influenza H1N1 virus infection in a time-dependent manner. 2012, 13:411 BMC Genomicsen_GB
dc.identifier.issn1471-2164en
dc.identifier.pmid22905720en
dc.identifier.doi10.1186/1471-2164-13-411en
dc.identifier.urihttp://hdl.handle.net/10033/278939en
dc.description.abstractThere is strong but mostly circumstantial evidence that genetic factors modulate the severity of influenza infection in humans. Using genetically diverse but fully inbred strains of mice it has been shown that host sequence variants have a strong influence on the severity of influenza A disease progression. In particular, C57BL/6J, the most widely used mouse strain in biomedical research, is comparatively resistant. In contrast, DBA/2J is highly susceptible.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to BMC genomicsen_GB
dc.subject.meshAllelesen_GB
dc.subject.meshAnimalsen_GB
dc.subject.meshBody Weighten_GB
dc.subject.meshChromosome Mappingen_GB
dc.subject.meshDisease Resistanceen_GB
dc.subject.meshHost-Pathogen Interactionsen_GB
dc.subject.meshInfluenza A Virus, H1N1 Subtypeen_GB
dc.subject.meshMiceen_GB
dc.subject.meshMice, Inbred C57BLen_GB
dc.subject.meshMice, Inbred DBAen_GB
dc.subject.meshOrthomyxoviridae Infectionsen_GB
dc.subject.meshQuantitative Trait Locien_GB
dc.subject.meshTime Factorsen_GB
dc.titleDistinct gene loci control the host response to influenza H1N1 virus infection in a time-dependent manner.en
dc.typeArticleen
dc.contributor.departmentDepartment of Infection Genetics, Helmholtz Centre for Infection Research and University of Veterinary Medicine Hannover, 38124, Braunschweig, Germany.en_GB
dc.identifier.journalBMC genomicsen_GB

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