Immunization with live virus vaccine protects highly susceptible DBA/2J mice from lethal influenza A H1N1 infection.

2.50
Hdl Handle:
http://hdl.handle.net/10033/288579
Title:
Immunization with live virus vaccine protects highly susceptible DBA/2J mice from lethal influenza A H1N1 infection.
Authors:
Dengler, Leonie; May, Mathias; Wilk, Esther ( 0000-0003-3446-5511 ) ; Bahgat, Mahmoud M; Schughart, Klaus ( 0000-0002-6824-7523 )
Abstract:
The mouse represents an important model system to study the host response to influenza A infections and to evaluate new prevention or treatment strategies. We and others reported that the susceptibility to influenza A virus infections strongly varies among different inbred mouse strains. In particular, DBA/2J mice are highly susceptible to several influenza A subtypes, including human isolates and exhibit severe symptoms after infection with clinical isolates.
Affiliation:
Department of Infection Genetics, Helmholtz Centre for Infection Research and University of Veterinary Medicine Hannover, Inhoffenstr. 7, D-38124 Braunschweig, Germany.
Citation:
Immunization with live virus vaccine protects highly susceptible DBA/2J mice from lethal influenza A H1N1 infection. 2012, 9:212 Virol. J.
Journal:
Virology journal
Issue Date:
2012
URI:
http://hdl.handle.net/10033/288579
DOI:
10.1186/1743-422X-9-212
PubMed ID:
22992381
Type:
Article
Language:
en
ISSN:
1743-422X
Appears in Collections:
publications of the department infection genetics (INFG)

Full metadata record

DC FieldValue Language
dc.contributor.authorDengler, Leonieen_GB
dc.contributor.authorMay, Mathiasen_GB
dc.contributor.authorWilk, Estheren_GB
dc.contributor.authorBahgat, Mahmoud Men_GB
dc.contributor.authorSchughart, Klausen_GB
dc.date.accessioned2013-05-07T08:54:54Zen
dc.date.available2013-05-07T08:54:54Zen
dc.date.issued2012en
dc.identifier.citationImmunization with live virus vaccine protects highly susceptible DBA/2J mice from lethal influenza A H1N1 infection. 2012, 9:212 Virol. J.en_GB
dc.identifier.issn1743-422Xen
dc.identifier.pmid22992381en
dc.identifier.doi10.1186/1743-422X-9-212en
dc.identifier.urihttp://hdl.handle.net/10033/288579en
dc.description.abstractThe mouse represents an important model system to study the host response to influenza A infections and to evaluate new prevention or treatment strategies. We and others reported that the susceptibility to influenza A virus infections strongly varies among different inbred mouse strains. In particular, DBA/2J mice are highly susceptible to several influenza A subtypes, including human isolates and exhibit severe symptoms after infection with clinical isolates.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Virology journalen_GB
dc.subject.meshAnimalsen_GB
dc.subject.meshAntibodies, Viralen_GB
dc.subject.meshAntibody Specificityen_GB
dc.subject.meshDisease Models, Animalen_GB
dc.subject.meshHumansen_GB
dc.subject.meshImmunoglobulin Gen_GB
dc.subject.meshInfluenza A Virus, H1N1 Subtypeen_GB
dc.subject.meshInfluenza Vaccinesen_GB
dc.subject.meshMiceen_GB
dc.subject.meshMice, Inbred C57BLen_GB
dc.subject.meshMice, Inbred DBAen_GB
dc.subject.meshOrthomyxoviridae Infectionsen_GB
dc.subject.meshVaccines, Attenuateden_GB
dc.titleImmunization with live virus vaccine protects highly susceptible DBA/2J mice from lethal influenza A H1N1 infection.en
dc.typeArticleen
dc.contributor.departmentDepartment of Infection Genetics, Helmholtz Centre for Infection Research and University of Veterinary Medicine Hannover, Inhoffenstr. 7, D-38124 Braunschweig, Germany.en_GB
dc.identifier.journalVirology journalen_GB

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