PAG/Cbp suppression reveals a contribution of CTLA-4 to setting the activation threshold in T cells.

2.50
Hdl Handle:
http://hdl.handle.net/10033/294281
Title:
PAG/Cbp suppression reveals a contribution of CTLA-4 to setting the activation threshold in T cells.
Authors:
Smida, Michal; Cammann, Clemens; Gurbiel, Slavyana; Kerstin, Nadja; Lingel, Holger; Lindquist, Sabine; Simeoni, Luca; Brunner-Weinzierl, Monika C; Suchanek, Miloslav; Schraven, Burkhart; Lindquist, Jonathan A
Abstract:
PAG/Cbp represents a ubiquitous mechanism for regulating Src family kinases by recruiting Csk to the plasma membrane, thereby controlling cellular activation. Since Src kinases are known oncogenes, we used RNA interference in primary human T cells to test whether the loss of PAG resulted in lymphocyte transformation.
Affiliation:
Institute of Molecular and Clinical Immunology, Otto-von-Guericke University, Leipziger Strasse 44, Magdeburg, 39120, Germany. jon.lindquist@med.ovgu.de.
Citation:
PAG/Cbp suppression reveals a contribution of CTLA-4 to setting the activation threshold in T cells. 2013, 11 (1):28 Cell Commun. Signal
Journal:
Cell communication and signaling : CCS
Issue Date:
2013
URI:
http://hdl.handle.net/10033/294281
DOI:
10.1186/1478-811X-11-28
PubMed ID:
23601194
Type:
Article
Language:
en
ISSN:
1478-811X
Appears in Collections:
publications of the department of immune control (IMMK)

Full metadata record

DC FieldValue Language
dc.contributor.authorSmida, Michalen_GB
dc.contributor.authorCammann, Clemensen_GB
dc.contributor.authorGurbiel, Slavyanaen_GB
dc.contributor.authorKerstin, Nadjaen_GB
dc.contributor.authorLingel, Holgeren_GB
dc.contributor.authorLindquist, Sabineen_GB
dc.contributor.authorSimeoni, Lucaen_GB
dc.contributor.authorBrunner-Weinzierl, Monika Cen_GB
dc.contributor.authorSuchanek, Miloslaven_GB
dc.contributor.authorSchraven, Burkharten_GB
dc.contributor.authorLindquist, Jonathan Aen_GB
dc.date.accessioned2013-06-20T09:16:48Z-
dc.date.available2013-06-20T09:16:48Z-
dc.date.issued2013-
dc.identifier.citationPAG/Cbp suppression reveals a contribution of CTLA-4 to setting the activation threshold in T cells. 2013, 11 (1):28 Cell Commun. Signalen_GB
dc.identifier.issn1478-811X-
dc.identifier.pmid23601194-
dc.identifier.doi10.1186/1478-811X-11-28-
dc.identifier.urihttp://hdl.handle.net/10033/294281-
dc.description.abstractPAG/Cbp represents a ubiquitous mechanism for regulating Src family kinases by recruiting Csk to the plasma membrane, thereby controlling cellular activation. Since Src kinases are known oncogenes, we used RNA interference in primary human T cells to test whether the loss of PAG resulted in lymphocyte transformation.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Cell communication and signaling : CCSen_GB
dc.titlePAG/Cbp suppression reveals a contribution of CTLA-4 to setting the activation threshold in T cells.en
dc.typeArticleen
dc.contributor.departmentInstitute of Molecular and Clinical Immunology, Otto-von-Guericke University, Leipziger Strasse 44, Magdeburg, 39120, Germany. jon.lindquist@med.ovgu.de.en_GB
dc.identifier.journalCell communication and signaling : CCSen_GB

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