Dipeptide cis-cyclo(Leucyl-Tyrosyl) produced by sponge associated Penicillium sp. F37 inhibits biofilm formation of the pathogenic Staphylococcus epidermidis.

2.50
Hdl Handle:
http://hdl.handle.net/10033/294441
Title:
Dipeptide cis-cyclo(Leucyl-Tyrosyl) produced by sponge associated Penicillium sp. F37 inhibits biofilm formation of the pathogenic Staphylococcus epidermidis.
Authors:
Scopel, Marina; Abraham, Wolf-Rainer ( 0000-0002-2850-2649 ) ; Henriques, Amélia T; Macedo, Alexandre J
Abstract:
Infections associated to microbial biofilms are involved in 80% of human infections and became a challenge concerning public health. Infections related to Staphylococcus epidermidis biofilms are presently commonly associated to medical devices, increasing treatment costs for this type of infection. Alternatives to eliminate this kind of disease have been employed in screening programs using diverse marine-derived fungi source of bioactive compounds capable to combat biofilm formation. In this work was isolated the dipeptide cis-cyclo(Leucyl-Tyrosyl) from a sponge associated Penicillium sp. possessing a remarkable inhibition up to 85% of biofilm formation without interfering with bacterial growth, confirmed by scanning electron microscopy. This is the first demonstration that cis-cyclo(Leucyl-Tyrosyl) is able to specifically inhibit biofilm formation adding another aspect to the broad spectrum of bioactivities of cyclic dipeptides.
Affiliation:
Faculdade de Farmácia, Departamento de Produção de Matéria-Prima, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, 2752, 90610-000 Porto Alegre, Brazil.
Citation:
Dipeptide cis-cyclo(Leucyl-Tyrosyl) produced by sponge associated Penicillium sp. F37 inhibits biofilm formation of the pathogenic Staphylococcus epidermidis. 2013, 23 (3):624-6 Bioorg. Med. Chem. Lett.
Journal:
Bioorganic & medicinal chemistry letters
Issue Date:
1-Feb-2013
URI:
http://hdl.handle.net/10033/294441
DOI:
10.1016/j.bmcl.2012.12.020
PubMed ID:
23290053
Type:
Article
Language:
en
ISSN:
1464-3405
Appears in Collections:
publications of the research group chemical microbiology (CMIK)

Full metadata record

DC FieldValue Language
dc.contributor.authorScopel, Marinaen_GB
dc.contributor.authorAbraham, Wolf-Raineren_GB
dc.contributor.authorHenriques, Amélia Ten_GB
dc.contributor.authorMacedo, Alexandre Jen_GB
dc.date.accessioned2013-06-24T11:31:04Z-
dc.date.available2013-06-24T11:31:04Z-
dc.date.issued2013-02-01-
dc.identifier.citationDipeptide cis-cyclo(Leucyl-Tyrosyl) produced by sponge associated Penicillium sp. F37 inhibits biofilm formation of the pathogenic Staphylococcus epidermidis. 2013, 23 (3):624-6 Bioorg. Med. Chem. Lett.en_GB
dc.identifier.issn1464-3405-
dc.identifier.pmid23290053-
dc.identifier.doi10.1016/j.bmcl.2012.12.020-
dc.identifier.urihttp://hdl.handle.net/10033/294441-
dc.description.abstractInfections associated to microbial biofilms are involved in 80% of human infections and became a challenge concerning public health. Infections related to Staphylococcus epidermidis biofilms are presently commonly associated to medical devices, increasing treatment costs for this type of infection. Alternatives to eliminate this kind of disease have been employed in screening programs using diverse marine-derived fungi source of bioactive compounds capable to combat biofilm formation. In this work was isolated the dipeptide cis-cyclo(Leucyl-Tyrosyl) from a sponge associated Penicillium sp. possessing a remarkable inhibition up to 85% of biofilm formation without interfering with bacterial growth, confirmed by scanning electron microscopy. This is the first demonstration that cis-cyclo(Leucyl-Tyrosyl) is able to specifically inhibit biofilm formation adding another aspect to the broad spectrum of bioactivities of cyclic dipeptides.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Bioorganic & medicinal chemistry lettersen_GB
dc.titleDipeptide cis-cyclo(Leucyl-Tyrosyl) produced by sponge associated Penicillium sp. F37 inhibits biofilm formation of the pathogenic Staphylococcus epidermidis.en
dc.typeArticleen
dc.contributor.departmentFaculdade de Farmácia, Departamento de Produção de Matéria-Prima, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, 2752, 90610-000 Porto Alegre, Brazil.en_GB
dc.identifier.journalBioorganic & medicinal chemistry lettersen_GB

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