Modular synthesis of polyene side chain analogues of the potent macrolide antibiotic etnangien by a flexible coupling strategy based on hetero-bis-metallated alkenes.

2.50
Hdl Handle:
http://hdl.handle.net/10033/302604
Title:
Modular synthesis of polyene side chain analogues of the potent macrolide antibiotic etnangien by a flexible coupling strategy based on hetero-bis-metallated alkenes.
Authors:
Altendorfer, Mario; Raja, Aruna; Sasse, Florenz; Irschik, Herbert; Menche, Dirk
Abstract:
An efficient procedure for the concise synthesis of hetero-bis-metallated alkenes as useful building blocks for the modular access to highly elaborate polyenes and stabilized analogues is reported. By applying these bifunctional olefins in convergent Stille/Suzuki-Miyaura couplings, novel, carefully selected side chain analogues of the potent RNA polymerase inhibitor etnangien were synthesized by a modular late stage coupling strategy and evaluated for antibacterial and antiproliferative activities.
Affiliation:
University of Heidelberg, Department of Organic Chemistry, INF 270, D-69120 Heidelberg, Germany, EU.
Citation:
Modular synthesis of polyene side chain analogues of the potent macrolide antibiotic etnangien by a flexible coupling strategy based on hetero-bis-metallated alkenes. 2013, 11 (13):2116-39 Org. Biomol. Chem.
Journal:
Organic & biomolecular chemistry
Issue Date:
7-Apr-2013
URI:
http://hdl.handle.net/10033/302604
DOI:
10.1039/c2ob26906f
PubMed ID:
23196931
Type:
Article
Language:
en
ISSN:
1477-0539
Appears in Collections:
publications of the department of microbial drugs (MWIS)

Full metadata record

DC FieldValue Language
dc.contributor.authorAltendorfer, Marioen
dc.contributor.authorRaja, Arunaen
dc.contributor.authorSasse, Florenzen
dc.contributor.authorIrschik, Herberten
dc.contributor.authorMenche, Dirken
dc.date.accessioned2013-10-02T08:38:32Z-
dc.date.available2013-10-02T08:38:32Z-
dc.date.issued2013-04-07-
dc.identifier.citationModular synthesis of polyene side chain analogues of the potent macrolide antibiotic etnangien by a flexible coupling strategy based on hetero-bis-metallated alkenes. 2013, 11 (13):2116-39 Org. Biomol. Chem.en
dc.identifier.issn1477-0539-
dc.identifier.pmid23196931-
dc.identifier.doi10.1039/c2ob26906f-
dc.identifier.urihttp://hdl.handle.net/10033/302604-
dc.description.abstractAn efficient procedure for the concise synthesis of hetero-bis-metallated alkenes as useful building blocks for the modular access to highly elaborate polyenes and stabilized analogues is reported. By applying these bifunctional olefins in convergent Stille/Suzuki-Miyaura couplings, novel, carefully selected side chain analogues of the potent RNA polymerase inhibitor etnangien were synthesized by a modular late stage coupling strategy and evaluated for antibacterial and antiproliferative activities.en
dc.language.isoenen
dc.rightsArchived with thanks to Organic & biomolecular chemistryen
dc.titleModular synthesis of polyene side chain analogues of the potent macrolide antibiotic etnangien by a flexible coupling strategy based on hetero-bis-metallated alkenes.en
dc.typeArticleen
dc.contributor.departmentUniversity of Heidelberg, Department of Organic Chemistry, INF 270, D-69120 Heidelberg, Germany, EU.en
dc.identifier.journalOrganic & biomolecular chemistryen

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