Tracking down biotransformation to the genetic level: identification of a highly flexible glycosyltransferase from Saccharothrix espanaensis.

2.50
Hdl Handle:
http://hdl.handle.net/10033/304824
Title:
Tracking down biotransformation to the genetic level: identification of a highly flexible glycosyltransferase from Saccharothrix espanaensis.
Authors:
Strobel, Tina; Schmidt, Yvonne; Linnenbrink, Anton; Luzhetskyy, Andriy ( 0000-0001-6497-0047 ) ; Luzhetska, Marta; Taguchi, Takaaki; Brötz, Elke; Paululat, Thomas; Stasevych, Maryna; Stanko, Oleg; Novikov, Volodymyr; Bechthold, Andreas
Abstract:
Saccharothrix espanaensis is a member of the order Actinomycetales. The genome of the strain has been sequenced recently, revealing 106 glycosyltransferase genes. In this paper, we report the detection of a glycosyltransferase from Saccharothrix espanaensis which is able to rhamnosylate different phenolic compounds targeting different positions of the molecules. The gene encoding the flexible glycosyltransferase is not located close to a natural product biosynthetic gene cluster. Therefore, the native function of this enzyme might be not the biosynthesis of a secondary metabolite but the glycosylation of internal and external natural products as part of a defense mechanism.
Affiliation:
Albert Ludwigs University of Freiburg, Department of Pharmaceutical Biology and Biotechnology, Freiburg, Germany.
Citation:
Tracking down biotransformation to the genetic level: identification of a highly flexible glycosyltransferase from Saccharothrix espanaensis. 2013, 79 (17):5224-32 Appl. Environ. Microbiol.
Journal:
Applied and environmental microbiology
Issue Date:
Sep-2013
URI:
http://hdl.handle.net/10033/304824
DOI:
10.1128/AEM.01652-13
PubMed ID:
23793643
Type:
Article
Language:
en
ISSN:
1098-5336
Appears in Collections:
publications of the research group metabolic engineering of Actinomycetes ([HIPS]AMEG)

Full metadata record

DC FieldValue Language
dc.contributor.authorStrobel, Tinaen
dc.contributor.authorSchmidt, Yvonneen
dc.contributor.authorLinnenbrink, Antonen
dc.contributor.authorLuzhetskyy, Andriyen
dc.contributor.authorLuzhetska, Martaen
dc.contributor.authorTaguchi, Takaakien
dc.contributor.authorBrötz, Elkeen
dc.contributor.authorPaululat, Thomasen
dc.contributor.authorStasevych, Marynaen
dc.contributor.authorStanko, Olegen
dc.contributor.authorNovikov, Volodymyren
dc.contributor.authorBechthold, Andreasen
dc.date.accessioned2013-10-30T15:19:00Zen
dc.date.available2013-10-30T15:19:00Zen
dc.date.issued2013-09en
dc.identifier.citationTracking down biotransformation to the genetic level: identification of a highly flexible glycosyltransferase from Saccharothrix espanaensis. 2013, 79 (17):5224-32 Appl. Environ. Microbiol.en
dc.identifier.issn1098-5336en
dc.identifier.pmid23793643en
dc.identifier.doi10.1128/AEM.01652-13en
dc.identifier.urihttp://hdl.handle.net/10033/304824en
dc.description.abstractSaccharothrix espanaensis is a member of the order Actinomycetales. The genome of the strain has been sequenced recently, revealing 106 glycosyltransferase genes. In this paper, we report the detection of a glycosyltransferase from Saccharothrix espanaensis which is able to rhamnosylate different phenolic compounds targeting different positions of the molecules. The gene encoding the flexible glycosyltransferase is not located close to a natural product biosynthetic gene cluster. Therefore, the native function of this enzyme might be not the biosynthesis of a secondary metabolite but the glycosylation of internal and external natural products as part of a defense mechanism.en
dc.language.isoenen
dc.rightsArchived with thanks to Applied and environmental microbiologyen
dc.titleTracking down biotransformation to the genetic level: identification of a highly flexible glycosyltransferase from Saccharothrix espanaensis.en
dc.typeArticleen
dc.contributor.departmentAlbert Ludwigs University of Freiburg, Department of Pharmaceutical Biology and Biotechnology, Freiburg, Germany.en
dc.identifier.journalApplied and environmental microbiologyen

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