Study of the in vivo role of Mce2R, the transcriptional regulator of mce2 operon in Mycobacterium tuberculosis.

2.50
Hdl Handle:
http://hdl.handle.net/10033/305358
Title:
Study of the in vivo role of Mce2R, the transcriptional regulator of mce2 operon in Mycobacterium tuberculosis.
Authors:
Forrellad, Marina Andrea; Bianco, María Verónica; Blanco, Federico Calos; Nuñez, Javier; Klepp, Laura Inés; Vazquez, Cristina Lourdes; de la Santangelo, María Paz; Rocha, Rosana Valeria; Soria, Marcelo; Golby, Paul; Gutierrez, Maximiliano Gabriel; Bigi, Fabiana
Abstract:
Tuberculosis is one of the leading causes of mortality throughout the world. Mycobacterium tuberculosis, the agent of human tuberculosis, has developed strategies involving proteins and other compounds called virulence factors to subvert human host defences and damage and invade the human host. Among these virulence-related proteins are the Mce proteins, which are encoded in the mce1, mce2, mce3 and mce4 operons of M. tuberculosis. The expression of the mce2 operon is negatively regulated by the Mce2R transcriptional repressor. Here we evaluated the role of Mce2R during the infection of M. tuberculosis in mice and macrophages and defined the genes whose expression is in vitro regulated by this transcriptional repressor.
Citation:
Study of the in vivo role of Mce2R, the transcriptional regulator of mce2 operon in Mycobacterium tuberculosis. 2013, 13 (1):200 BMC Microbiol.
Journal:
BMC microbiology
Issue Date:
5-Sep-2013
URI:
http://hdl.handle.net/10033/305358
DOI:
10.1186/1471-2180-13-200
PubMed ID:
24007602
Type:
Article
ISSN:
1471-2180
Appears in Collections:
collections of the research group microbial communication (KOM)

Full metadata record

DC FieldValue Language
dc.contributor.authorForrellad, Marina Andreaen
dc.contributor.authorBianco, María Verónicaen
dc.contributor.authorBlanco, Federico Calosen
dc.contributor.authorNuñez, Javieren
dc.contributor.authorKlepp, Laura Inésen
dc.contributor.authorVazquez, Cristina Lourdesen
dc.contributor.authorde la Santangelo, María Pazen
dc.contributor.authorRocha, Rosana Valeriaen
dc.contributor.authorSoria, Marceloen
dc.contributor.authorGolby, Paulen
dc.contributor.authorGutierrez, Maximiliano Gabrielen
dc.contributor.authorBigi, Fabianaen
dc.date.accessioned2013-11-14T10:08:59Zen
dc.date.available2013-11-14T10:08:59Zen
dc.date.issued2013-09-05en
dc.identifier.citationStudy of the in vivo role of Mce2R, the transcriptional regulator of mce2 operon in Mycobacterium tuberculosis. 2013, 13 (1):200 BMC Microbiol.en
dc.identifier.issn1471-2180en
dc.identifier.pmid24007602en
dc.identifier.doi10.1186/1471-2180-13-200en
dc.identifier.urihttp://hdl.handle.net/10033/305358en
dc.description.abstractTuberculosis is one of the leading causes of mortality throughout the world. Mycobacterium tuberculosis, the agent of human tuberculosis, has developed strategies involving proteins and other compounds called virulence factors to subvert human host defences and damage and invade the human host. Among these virulence-related proteins are the Mce proteins, which are encoded in the mce1, mce2, mce3 and mce4 operons of M. tuberculosis. The expression of the mce2 operon is negatively regulated by the Mce2R transcriptional repressor. Here we evaluated the role of Mce2R during the infection of M. tuberculosis in mice and macrophages and defined the genes whose expression is in vitro regulated by this transcriptional repressor.en
dc.languageENGen
dc.rightsArchived with thanks to BMC microbiologyen
dc.titleStudy of the in vivo role of Mce2R, the transcriptional regulator of mce2 operon in Mycobacterium tuberculosis.en
dc.typeArticleen
dc.identifier.journalBMC microbiologyen

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